Category Archives: Uncategorized

PMID:  Artif Cells Nanomed Biotechnol. 2018 ;46(sup3):S707-S716. Epub 2018 Oct 4. PMID: 30284484 Abstract Title:  Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions in a mice model: role of NF-κB pathway. Abstract:  Our previous works have shown that tanshinone IIA inhibited maladaptive extracellular matrix remodeling in cardiac fibroblasts implicating its potential …

Continue reading “Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions”

PMID:  Am J Transl Res. 2019 ;11(5):2995-3006. Epub 2019 May 15. PMID: 31217869 Abstract Title:  Tanshinone IIA induces apoptosis and autophagy in acute monocytic leukemia via downregulation of PI3K/Akt pathway. Abstract:  Acute myeloid leukemia (AML) is characterized by unrestrained proliferation of myeloid cells. In has been shown that tanshinone IIA (Tan IIA), exhibited anti-tumor activities …

Continue reading “Tanshinone IIA induces apoptosis and autophagy in acute monocytic leukemia.”

PMID:  Am J Transl Res. 2019 ;11(5):3140-3149. Epub 2019 May 15. PMID: 31217883 Abstract Title:  Tanshinone IIA ameliorates oxaliplatin-induced neurotoxicity via mitochondrial protection and autophagy promotion. Abstract:  Peripheral neurotoxicity is a common adverse reaction in cancer patients undergoing chemotherapy. The neuropathologic changes were partly associated with mitochondrial dysfunction and autophagy. Tanshinone IIA, a compound extracted …

Continue reading “Tanshinone IIA ameliorates oxaliplatin-induced neurotoxicity via mitochondrial protection and autophagy promotion.”

PMID:  Med Sci Monit. 2019 Jun 28 ;25:4793-4800. Epub 2019 Jun 28. PMID: 31250836 Abstract Title:  Effects and Mechanism of Tanshinone II A in Proliferation, Apoptosis, and Migration of Human Colon Cancer Cells. Abstract:  BACKGROUND The aim of this study was to explore the effect and mechanism of tanshinone II A on proliferation, apoptosis, and …

Continue reading “Tanshinone II A is able to inhibit proliferation and migration of human colon cancer SW620 cells and promoted cell death.”

PMID:  Exp Ther Med. 2019 Jul ;18(1):729-734. Epub 2019 May 15. PMID: 31258708 Abstract Title:  Tanshinone IIA ameliorates diabetic cardiomyopathy by inhibiting Grp78 and CHOP expression in STZ-induced diabetes rats. Abstract:  Diabetic cardiomyopathy (DCM), one of the common diabetic complications, causes a high rate of mortality in patients with diabetes. Tanshinone IIA (TSIIA), one of …

Continue reading “Tanshinone IIA ameliorates diabetic cardiomyopathy.”

PMID:  Cancers (Basel). 2019 Jun 28 ;11(7). Epub 2019 Jun 28. PMID: 31261758 Abstract Title:  Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1. Abstract:  Clinical use of the anti-cancer drug doxorubicin (DOX) is largely limited due to its severe cardiotoxicity. Dysregulation of autophagy is implicated in DOX-induced cardiotoxicity (DIC). Prior …

Continue reading “Tanshinone IIA restores dynamic balance of autophagosome/autolysosome in doxorubicin-induced cardiotoxicity.”

PMID:  J Recept Signal Transduct Res. 2019 Apr ;39(2):134-145. Epub 2019 Jul 29. PMID: 31354004 Abstract Title:  Inhibitory effect of Tanshinone IIA on inverted formin-2 protects HaCaT cells against oxidative injury via regulating mitochondrial stress. Abstract:  Epidermal cells play an important role in regulating the regeneration of skin after burns and wounds.The aim of our …

Continue reading “Inhibitory effect of tanshinone IIA on inverted formin-2 protects HaCaT cells against oxidative injury via regulating mitochondrial stress.”

n/a PMID:  Electromagn Biol Med. 2019 Aug 26:1-18. Epub 2019 Aug 26. PMID: 31450976 Abstract Title:  Exposure to Static and Extremely-Low Frequency Electromagnetic Fields and Cellular Free Radicals. Abstract:  This paper summarizes studies on changes in cellular free radical activities from exposure to static and extremely-low frequency (ELF) electromagnetic fields (EMF), particularly magnetic fields. Changes …

Continue reading “Electromagnetic field exposure may induce DNA damage, stimulate inflammation, and impact cell proliferation and differentiation.”

n/a PMID:  J Chem Neuroanat. 2019 Aug 26 ;101:101681. Epub 2019 Aug 26. PMID: 31465830 Abstract Title:  Changes in pyramidal and granular neuron numbers in the rat hippocampus 7 days after exposure to a continuous 900-MHz electromagnetic field during early and mid-adolescence. Abstract:  The aim of this study was to investigate qualitative and quantitative changes …

Continue reading “900-MHz electromagnetic fields induce histopathological changes in the rat hippocampus.”

n/a PMID:  Environ Res. 2019 Nov ;178:108688. Epub 2019 Aug 24. PMID: 31476684 Abstract Title:  Extremely low frequency electromagnetic fields and cancer: How source of funding affects results. Abstract:  While there has been evidence indicating that excessive exposure to magnetic fields from 50 to 60 Hz electricity increases risk of cancer, many argue that the evidence …

Continue reading “Hearing aid users may be at risk of high electromagnetic field exposure that may be accompanied by adverse side effects, especially in the tissues of the head.”