n/a PMID: Food Chem. 2020 Jan 30 ;304:125442. Epub 2019 Aug 28. PMID: 31491714 Abstract Title: Influence of moderate electric fields inβ-lactoglobulin thermal unfolding and interactions. Abstract: In this study, the effects of moderate electric fields during thermal denaturation ofβ-lactoglobulin were examined through an in situ circular dichroism approach, complemented by intrinsic extrinsic fluorescence analysis. …
Category Archives: Uncategorized
Tanshinone IIA attenuates cardiac microvascular ischemia-reperfusion injury.
PMID: Cell Stress Chaperones. 2019 Sep ;24(5):991-1003. Epub 2019 Aug 6. PMID: 31388827 Abstract Title: Tanshinone IIA attenuates cardiac microvascular ischemia-reperfusion injury via regulating the SIRT1-PGC1α-mitochondrial apoptosis pathway. Abstract: Cardiac microvascular ischemia-reperfusion (IR) injury has been a neglected topic in recent decades. In the current study, we investigated the mechanism underlying microvascular IR injury, with …
Continue reading “Tanshinone IIA attenuates cardiac microvascular ischemia-reperfusion injury.”
Tanshinone IIA could stabilize vulnerable aortic atherosclerotic plaque in ApoE-/- mice.
PMID: Front Pharmacol. 2019 ;10:850. Epub 2019 Jul 26. PMID: 31402870 Abstract Title: Tanshinone IIA Exerts Anti-Inflammatory and Immune-Regulating Effects on Vulnerable Atherosclerotic Plaque Partiallythe TLR4/MyD88/NF-κB Signal Pathway. Abstract: Tanshinone IIA (Tan IIA), a lipophilic constituent fromBunge, has shown a promising cardioprotective effect including anti-atherosclerosis. This study aims at exploring Tan IIA's anti-inflammatory and immune-regulating …
Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response.
PMID: Mol Med Rep. 2019 Aug ;20(2):1621-1628. Epub 2019 Jun 20. PMID: 31257487 Abstract Title: Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response. Abstract: The inflammatory response plays a vital role in cerebral aneurysm (CA) formation and progression. Tanshinone IIA (Tan IIA) is one of the major active components of Chinese medicine …
Tanshinone IIA inhibits the adipogenesis and inflammatory response in ox-LDL-challenged human monocyte-derived macrophages.
PMID: J Cell Biochem. 2019 Sep 12. Epub 2019 Sep 12. PMID: 31512787 Abstract Title: Tanshinone IIA inhibits the adipogenesis and inflammatory response in ox-LDL-challenged human monocyte-derived macrophages via regulating miR-130b/WNT5A. Abstract: Atherosclerosis is a kind of chronic cardiovascular disease, characterized by oxidized low-density lipoprotein (ox-LDL) accumulation in macrophage. Tanshinone IIA (Tan), a lipophilic pharmacologically …
Tanshinone IIA may function as a novel option for combination therapy for non-small-cell lung cancer treatment.
PMID: Phytother Res. 2019 Sep ;33(9):2298-2309. Epub 2019 Jul 3. PMID: 31268205 Abstract Title: Tanshinone IIA combined with cisplatin synergistically inhibits non-small-cell lung cancer in vitro and in vivo via down-regulating the phosphatidylinositol 3-kinase/Akt signalling pathway. Abstract: Cisplatin represents one of the first-line drugs used for non-small-cell lung cancer treatment. However, considerable side effects and …
Tanshinone IIA exerts beneficial effects on fracture healing in vitro and in vivo.
PMID: Chem Biol Interact. 2019 Sep 1 ;310:108748. Epub 2019 Jul 12. PMID: 31306638 Abstract Title: Tanshinone IIA exerts beneficial effects on fracture healing in vitro and in vivo. Abstract: BACKGROUND: Fracture healing is a very important process after fracture. Tanshinone IIA (Tan IIA) has been reported to possess beneficial impact on osteoblasts growth. Our …
Tanshinone II A affects diabetic peripheral neuropathic pain.
n/a PMID: Exp Clin Endocrinol Diabetes. 2019 Jul 11. Epub 2019 Jul 11. PMID: 31295750 Abstract Title: Tanshinone II A Affects Diabetic Peripheral Neuropathic Pain via Spinal Dorsal Horn Neuronal Circuitry by Modulating Endoplasmic Reticulum Stress Pathways. Abstract: Diabetic peripheral neuropathic pain (DPNP) is a common manifestation of diabetic peripheral neuropathy (DPN). Although the pathogenesis …
Continue reading “Tanshinone II A affects diabetic peripheral neuropathic pain.”
TanshinoneⅡA attenuates carotid artery atherosclerosis by deactivating mast cells in adventitia.
PMID: Zhonghua Xin Xue Guan Bing Za Zhi. 2019 Aug 24 ;47(8):634-639. PMID: 31434435 Abstract Title: [TanshinoneⅡA attenuates carotid artery atherosclerosis by deactivating mast cells in adventitia]. Abstract: To investigate the effects of tanshinoneⅡA on atherosclerosis plaque formation and adventitial mast cells activation in high-fat-diet induced Apo E(-/-) mice model.Sixteen 8-week-old Apo E(-/-)male mice and …
Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells.
PMID: Oncol Lett. 2019 Sep ;18(3):3317-3322. Epub 2019 Jul 24. PMID: 31452810 Abstract Title: Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53-cyclin B1/CDC2. Abstract: Tanshinone IIA exhibits natural antioxidative and antineoplastic activity. However, to the best of our knowledge, the effects of tanshinone IIA on human nasopharyngeal carcinoma cells …
Health Time 