PMID: Phytother Res. 2012 Aug ;26(8):1133-41. Epub 2011 Dec 14. PMID: 22170854 Abstract Title: Liquiritigenin inhibits serum-induced HIF-1α and VEGF expression via the AKT/mTOR-p70S6K signalling pathway in HeLa cells. Abstract: Liquiritigenin (LQ) is a non-toxic dietary flavonoid with chemopreventive and anticancer properties. However, the mechanism of its antiangiogenesis remains unclear. Hypoxia-inducible factor-1α (HIF-1α) and its …
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Liquiritigenin may be considered as a potential interfering agent of cancer progression.
PMID: Nutr Cancer. 2012 ;64(4):627-34. Epub 2012 Apr 20. PMID: 22519916 Abstract Title: Inhibitory effect of liquiritigenin on migration via downregulation proMMP-2 and PI3K/Akt signaling pathway in human lung adenocarcinoma A549 cells. Abstract: Liquiritigenin (LQ) is a flavanone extracted from Glycyrrhizae, which has multiple biological effects, such as antiinflammation and anticancer. This study is the …
Liquiritigenin inhibits tumor growth and vascularization in a mouse model of HeLa cells.
PMID: Molecules. 2012 Jun 12 ;17(6):7206-16. Epub 2012 Jun 12. PMID: 22692244 Abstract Title: Liquiritigenin inhibits tumor growth and vascularization in a mouse model of HeLa cells. Abstract: Angiogenesis is one of the crucial steps in the transition of a tumor from a small, harmless cluster of mutated cells to a large, malignant growth, capable …
Liquiritigenin prevents acute liver injuries in rats induced by acetaminophen.
PMID: Chem Biol Interact. 2006 Jun 10 ;161(2):125-38. Epub 2006 Mar 27. PMID: 16647697 Abstract Title: Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine. Abstract: Glycyrrhizae radix has been used as one of the oldest and most frequently employed botanicals in …
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Cannabis: Misinformation about CBD can be life-threatening
Hyperbole can be rampant in health news, particularly with respect to cannabis. One recent headline declared: “CBD is effective in treating heroin addiction.” Another proclaimed: “New study finds CBD could curb heroin addiction.” These stories were referring to a recent study in the American Journal of Psychiatry that found a short-term course of cannabidiol (CBD) reduced cue-induced cravings and anxiety in …
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Liquiritigenin prevents Staphylococcus aureus-mediated lung cell injury via inhibiting the production of α-hemolysin.
PMID: J Asian Nat Prod Res. 2013 ;15(4):390-9. Epub 2013 Mar 6. PMID: 23464667 Abstract Title: Liquiritigenin prevents Staphylococcus aureus-mediated lung cell injury via inhibiting the production ofα-hemolysin. Abstract: Staphylococcus aureus is a significant Gram-positive bacterium that is associated with a broad spectrum of diseases ranging from minor skin infections to lethal pneumonia, endocarditis, and …
Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells.
PMID: Neurotoxicology. 2013 Dec ;39:114-23. Epub 2013 Sep 5. PMID: 24012889 Abstract Title: Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells. Abstract: The progressive death of neurons following exposure to high concentrations of glutamate leads to loss of learning and memory and pathogenesis of neurodegenerative disorders. Therefore, identification …
Liquiritigenin restores osteoblast damage through regulating oxidative stress and mitochondrial dysfunction.
PMID: Phytother Res. 2014 Jun ;28(6):880-6. Epub 2013 Oct 3. PMID: 24123597 Abstract Title: Liquiritigenin restores osteoblast damage through regulating oxidative stress and mitochondrial dysfunction. Abstract: We investigated the protective effect of liquiritigenin, one of the flavonoids present in Glycyrrhizae radix, against antimycin A-induced mitochondrial dysfunction in MC3T3-E1 osteoblast cells. Osteoblastic MC3T3-E1 cells were pre-incubated …
The study provides experimental evidence supporting liquiritigenin as a potential therapeutic agent for hepatocellular carcinoma treatment.
PMID: Biomed Res Int. 2014 ;2014:965316. Epub 2014 Mar 11. PMID: 24738081 Abstract Title: Liquiritigenin induces tumor cell death through mitogen-activated protein kinase- (MPAKs-) mediated pathway in hepatocellular carcinoma cells. Abstract: Liquiritigenin (LQ), separated from Glycyrrhiza radix, possesses anti-inflammatory, antihyperlipidemic, and antiallergic effects. Our present study aims to investigate the antihepatocellular carcinoma effects of LQ …
Liquiritigenin potentiates the inhibitory effects of cisplatin on invasion and metastasis in B16F10 melanoma cells.
PMID: Nutr Cancer. 2015 ;67(5):761-70. Epub 2015 May 15. PMID: 25978595 Abstract Title: Liquiritigenin Potentiates the Inhibitory Effects of Cisplatin on Invasion and Metastasis Via Downregulation MMP-2/9 and PI3 K/AKT Signaling Pathway in B16F10 Melanoma Cells and Mice Model. Abstract: Liquiritigenin (LQ) is a flavanone extracted from glycyrrhizae. Previous studies have demonstrated that LQ possesses …
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