PMID: Cells. 2019 Sep 15 ;8(9). Epub 2019 Sep 15. PMID: 31540162 Abstract Title: Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models. Abstract: Psoriasis is a chronic immune-mediated skin disease that involves the interaction of immune and skin cells, and is …
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Fisetin may be developed as a potential nutritional target for the prevention of lead-induced neurotoxicity.
PMID: Food Chem Toxicol. 2019 Sep 17 ;134:110824. Epub 2019 Sep 17. PMID: 31539617 Abstract Title: Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK/SIRT1 and autophagy pathway. Abstract: Fisetin, a natural flavonoid found in plants, fruits and vegetables, exerts anti-cancer, anti-oxidant, anti-inflammatory and anti-mitotic effects. The current study instigates …
Fisetin improved the hippocampal-dependent synaptic and memory functions in LPS-treated adult mice.
PMID: J Clin Med. 2019 Jun 14 ;8(6). Epub 2019 Jun 14. PMID: 31207963 Abstract Title: Phytomedicine-Based Potent Antioxidant, Fisetin Protects CNS-Insult LPS-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment. Abstract: Phytomedicine based natural flavonoids have potent antioxidant, anti-inflammatory, and neuroprotective activities against neurodegenerative diseases. The aim of the present study is to investigate the potent …
Fisetin prolongs therapy window of brain ischemic stroke using tissue plasminogen activator.
PMID: Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619871359. PMID: 31434498 Abstract Title: Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial. Abstract: Recombinant tissue plasminogen activator (rt-PA) can be utilized to treat ischemic stroke with safety and effectiveness but limited by a narrow therapeutic window. In the …
Liquiritigenin protects rats from carbon tetrachloride induced hepatic injury through PGC-1α pathway.
PMID: Evid Based Complement Alternat Med. 2015 ;2015:649568. Epub 2015 Jun 25. PMID: 26199636 Abstract Title: Liquiritigenin Protects Rats from Carbon Tetrachloride Induced Hepatic Injury through PGC-1α Pathway. Abstract: The lack of effective treatment for liver cirrhosis and hepatocellular carcinomas imposes serious challenges to the healthcare system. Here, we investigated the efficacy and mechanism of …
Protective effect of liquiritigenin on depressive-like behavior in mice after lipopolysaccharide administration.
PMID: Psychiatry Res. 2016 Jun 30 ;240:131-136. Epub 2016 Apr 14. PMID: 27107388 Abstract Title: Protective effect of liquiritigenin on depressive-like behavior in mice after lipopolysaccharide administration. Abstract: Liquiritigenin (Liq), the main active ingredient of traditional Chinese medicine licorice, possesses anti-inflammatory and neuroprotective properties. The current investigation was designed to explore whether liquiritigenin could relieve …
Liquiritigenin may be a potential candidate for diabetes-associated cardiac injury.
PMID: Biomed Pharmacother. 2017 Feb ;86:694-704. Epub 2016 Dec 28. PMID: 28039849 Abstract Title: Liquiritigenin attenuates cardiac injury induced by high fructose-feeding through fibrosis and inflammation suppression. Abstract: Diabetes combined with cardiomyopathy is considered as an essential complication, showing diastolic persistently and causing cardiac injury, which is linked to fibrosis progression and inflammation response. Fibrosis …
Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress.
PMID: Behav Brain Res. 2016 07 15 ;308:177-86. Epub 2016 Apr 22. PMID: 27113683 Abstract Title: Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway. Abstract: Major depression is a common long-lasting or recurrent psychiatric disease with high lifetime prevalence and high incidence of suicide. The main purpose …
Antihyperuricemic effect of liquiritigenin in potassium oxonate-induced hyperuricemic rats.
PMID: Biomed Pharmacother. 2016 Dec ;84:1930-1936. Epub 2016 Nov 15. PMID: 27863839 Abstract Title: Antihyperuricemic effect of liquiritigenin in potassium oxonate-induced hyperuricemic rats. Abstract: The aim is to investigate the anti-hyperuricemic and renal protective effects of liquiritigenin in potassium oxonate-induced hyperuricemic rats. Hyperuricemia in rats was induced were induced with potassium oxonate (250mg/kg) intragastrically for …
Brazilian propolis extract reduces intestinal barrier defects and inflammation in a colitic mouse model.
PMID: Nutr Res. 2019 Jul 30 ;69:30-41. Epub 2019 Jul 30. PMID: 31470289 Abstract Title: Brazilian propolis extract reduces intestinal barrier defects and inflammation in a colitic mouse model. Abstract: Brazilian propolis is rich in cinnamic acid derivatives and reportedly reduces intestinal inflammation in rodents; however, the underlying mechanisms remain unclear. We hypothesized that the …
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