PMID: Eur J Pharmacol. 2018 Feb 15 ;821:57-67. Epub 2017 Dec 23. PMID: 29277717 Abstract Title: Antineoplastic activity of isoliquiritigenin, a chalcone compound, in androgen-independent human prostate cancer cells linked to G2/M cell cycle arrest and cell apoptosis. Abstract: Isoliquiritigenin is a natural chalcone derived from Glycyrrhiza, which has been reported to have anti-tumor activity …
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These findings suggest that isoliquiritigenin can reduce ethanol induced-hepatic lipogenesis.
PMID: Toxicol Res. 2018 Jan ;34(1):23-29. Epub 2018 Jan 15. PMID: 29371998 Abstract Title: Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway. Abstract: Ethanol-induced fat accumulation, the earliest and most common response of the liver to ethanol exposure, may be involved in the pathogenesis of liver diseases. Isoliquiritigenin (ISL), an …
These results indicated that isoliquiritigenin attenuates progression of osteoarthritis.
PMID: Sci Rep. 2018 01 29 ;8(1):1721. Epub 2018 Jan 29. PMID: 29379010 Abstract Title: Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone. Abstract: Isoliquiritigenin (ISL), a natural flavonoid extracted from licorice, has been demonstrated to exert attenuation of osteoclastogenesis and anti-angiogenesis activity in a wide variety of cells. Here, …
Isoliquiritigenin ameliorates indomethacin-induced small intestinal damage.
PMID: Pharmacology. 2018 ;101(5-6):236-245. Epub 2018 Jan 26. PMID: 29393276 Abstract Title: Isoliquiritigenin Ameliorates Indomethacin-Induced Small Intestinal Damage by Inhibiting NOD-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation. Abstract: Activation of the NOD-Like Receptor Family, Pyrin Domain-Containing 3 (NLRP3) inflammasome, which consists of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and pro-caspase-1, …
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Isoliquiritigenin inhibited viability, proliferation, and invasion, and induced apoptosis of SKOV3 and OVCAR3 cells.
PMID: Onco Targets Ther. 2018 ;11:1633-1642. Epub 2018 Mar 22. PMID: 29606882 Abstract Title: Effects of isoliquiritigenin on ovarian cancer cells. Abstract: Background: Ovarian cancer is one of the most fatal gynecologic malignancies, with most patients diagnosed at the late stage due to insidious onset and lack of early onset specific symptoms. Previous studies have …
Isoliquiritigenin inhibited the inflammatory of LPS-induced lung injury by activating PPAR-γ and inhibiting NF-κB activation.
PMID: Inflammation. 2018 Aug ;41(4):1290-1296. PMID: 29654430 Abstract Title: Protective Effects of Isoliquiritigenin on LPS-Induced Acute Lung Injury by Activating PPAR-γ. Abstract: Isoliquiritigenin (ILG), a major ingredient of licorice, has been reported to have anti-oxidative and anti-inflammatory effects. The aim of this study was to investigate the protective effects of ILG on lung injury using …
These results suggest a potential therapeutic role of isoliquiritigenin to treat osteoarthritis.
PMID: Mol Ther Methods Clin Dev. 2018 Jun 15 ;9:153-159. Epub 2018 Feb 15. PMID: 29766025 Abstract Title: Isoliquiritigenin Inhibits IL-1β-Induced Production of Matrix Metalloproteinase in Articular Chondrocytes. Abstract: Osteoarthritis (OA) is a major joint disease in which inflammatory cytokine interleukin-1β (IL-1β) and matrix metalloproteinases (MMPs) play a pivotal role. Isoliquiritigenin has been reported to …
This data for the first time confirmed the protective effects of isoliquiritigenin on acute pancreatitis.
PMID: Oxid Med Cell Longev. 2018 ;2018:7161592. Epub 2018 Apr 26. PMID: 29854090 Abstract Title: Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway. Abstract: Oxidative stress plays a crucial role in the pathogenesis of acute pancreatitis (AP). Isoliquiritigenin (ISL) is a flavonoid monomer with confirmed antioxidant …
Isoliquiritigenin attenuates spinal tuberculosis through inhibiting immune response.
PMID: Korean J Physiol Pharmacol. 2018 Jul ;22(4):369-377. Epub 2018 Jun 25. PMID: 29962851 Abstract Title: Isoliquiritigenin attenuates spinal tuberculosis through inhibiting immune response in a New Zealand white rabbit model. Abstract: Spinal tuberculosis (ST) is the tuberculosis caused by() infections in spinal curds. Isoliquiritigenin 4,2',4'-trihydroxychalcone, ISL) is an anti-inflammatory flavonoid derived from licorice (), …
Licorice isoliquiritigenin-encapsulated mesoporous silica nanoparticles for osteoclast inhibition and bone loss prevention.
PMID: Theranostics. 2019 ;9(18):5183-5199. Epub 2019 Jul 9. PMID: 31410209 Abstract Title: Licorice isoliquiritigenin-encapsulated mesoporous silica nanoparticles for osteoclast inhibition and bone loss prevention. Abstract: Mesoporous silica nanoparticles (MSNs) are extensively used in bone tissue regeneration and local drug delivery. However, the effects of MSNs alone on osteoclast formation and function, as well as the …
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