Category Archives: Uncategorized

PMID:  Chemotherapy. 2018 ;63(3):155-161. Epub 2018 Jun 22. PMID: 29936511 Abstract Title:  Isoliquiritigenin Suppresses Osteosarcoma U2OS Cell Proliferation and Invasion by Regulating the PI3K/Akt Signalling Pathway. Abstract:  AIMS: Isoliquiritigenin (ISL) is a flavonoid, that has been shown to have antioxidant, vasorelaxant, anti-inflammatory, and antitumor activities. This study aimed to explore the antitumor effect of ISL …

Continue reading “Isoliquiritigenin Suppresses Osteosarcoma U2OS Cell Proliferation and Invasion.”

PMID:  Inflammopharmacology. 2019 Aug ;27(4):809-816. Epub 2018 Jun 26. PMID: 29943151 Abstract Title:  Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB. Abstract:  BACKGROUND: The study was conducted to scrutinize the outcome of isoliquiritigenin (ISL) against cerebral injury in septic mice.METHODS: The sepsis was introduced using cecal ligation and puncture …

Continue reading “Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB.”

PMID:  Mol Med Rep. 2018 Sep ;18(3):3429-3436. Epub 2018 Jul 25. PMID: 30066879 Abstract Title:  Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway. Abstract:  Isoliquiritigenin (ISL) is aflavonoid extracted from licorice root, which is known to serve important antitumor roles in numerous types of cancers; however, its …

Continue reading “Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells.”

PMID:  J Exp Clin Cancer Res. 2018 Aug 6 ;37(1):184. Epub 2018 Aug 6. PMID: 30081934 Abstract Title:  Isoliquiritigenin suppresses human melanoma growth by targeting miR-301b/LRIG1 signaling. Abstract:  BACKGROUND: Isoliquiritigenin (ISL), a natural flavonoid isolated from the root of licorice (Glycyrrhiza uralensis), has shown various pharmacological properties including anti-oxidant, anti-inflammatory and anti-cancer activities. MicroRNAs (miRNAs), …

Continue reading “Isoliquiritigenin may inhibit the proliferation of melanoma cells by suppressing miR-301b and inducing its target LRIG1.”

PMID:  Front Pharmacol. 2018 ;9:936. Epub 2018 Aug 17. PMID: 30174606 Abstract Title:  Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling. Abstract:  Severe acute pancreatitis (SAP) is a digestive system disease that is associated with a range of complications including intestinal dysfunction. In this study, we determined that …

Continue reading “Isoliquiritigenin protects against pancreatic injury and intestinal dysfunction after severe acute pancreatitis.”

PMID:  Zhejiang Da Xue Xue Bao Yi Xue Ban. 2018 May 25 ;47(2):181-186. PMID: 30226314 Abstract Title:  [Isoliquiritigenin can inhibit migration and invasion of human glioma stem cells by down-regulating matrix metalloproteinases]. Abstract:  OBJECTIVE: To investigate the effects of isoliquiritigenin on the migration and invasion of human glioma stem cells and the underlying mechanism.METHODS: The …

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PMID:  J Exp Clin Cancer Res. 2018 Oct 3 ;37(1):243. Epub 2018 Oct 3. PMID: 30285892 Abstract Title:  Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2', 4'-Tetrahydroxychalcone. Abstract:  BACKGROUND: Licorice is an herb extensively used for both culinary and medicinal purposes. Various constituents of licorice have been shown to exhibit …

Continue reading “Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2′, 4′-Tetrahydroxychalcone.”

PMID:  Int Immunopharmacol. 2018 Dec ;65:64-75. Epub 2018 Oct 2. PMID: 30290368 Abstract Title:  Isoliquiritigenin protects against blood‑brain barrier damage and inhibits the secretion of pro-inflammatory cytokines in mice after traumatic brain injury. Abstract:  Traumatic brain injury (TBI) caused by an external mechanical force acting on the brain is a serious neurological condition. Inflammation plays …

Continue reading “Isoliquiritigenin protects against blood brain barrier damage and inhibits the secretion of pro-inflammatory cytokines in mice after traumatic brain injury.”

PMID:  Front Pharmacol. 2018 ;9:1001. Epub 2018 Sep 20. PMID: 30294270 Abstract Title:  Isoliquiritigenin Inhibits Cigarette Smoke-Induced COPD by Attenuating Inflammation and Oxidative Stress via the Regulation of the Nrf2 and NF-κB Signaling Pathways. Abstract:  Chronic obstructive pulmonary disease (COPD) is the major leading cause of disease with high-mortality worldwide. Cigarette smoke (CS) is a …

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PMID:  Eur J Pharmacol. 2018 Dec 15 ;841:90-97. Epub 2018 Oct 16. PMID: 30339814 Abstract Title:  Isoliquiritigenin-mediated p62/SQSTM1 induction regulates apoptotic potential through attenuation of caspase-8 activation in colorectal cancer cells. Abstract:  Isoliquiritigenin (ISL) is a natural flavonoid that exhibits anticancer properties in various carcinoma cell types. However, the precise mechanism responsible for its anticancer …

Continue reading “These findings broaden the understanding of the molecular basis of Isoliquiritigenin-mediated apoptosis.”