PMID: Oncol Lett. 2018 Nov ;16(5):6133-6139. Epub 2018 Aug 21. PMID: 30344755 Abstract Title: Isoliquiritigenin inhibits cell proliferation and migration through the PI3K/AKT signaling pathway in A549 lung cancer cells. Abstract: The present study aimed to investigate the molecular mechanisms of inhibition of Isoliquiritigenin (ISL) on the proliferation and migration of A549 cells. A549 cells …
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Dietary isoliquiritigenin at a low dose ameliorates insulin resistance and NAFLD in diet-induced obesity.
PMID: Int J Mol Sci. 2018 Oct 22 ;19(10). Epub 2018 Oct 22. PMID: 30360437 Abstract Title: Dietary Isoliquiritigenin at a Low Dose Ameliorates Insulin Resistance and NAFLD in Diet-Induced Obesity in C57BL/6J Mice. Abstract: Isoliquiritigenin (ILG) is a flavonoid constituent ofplants. The current study investigated the effects of ILG on diet-induced obesity and metabolic …
Isoliquiritigenin provides protection and attenuates oxidative stress-induced injuries after traumatic brain injury.
PMID: Neurochem Res. 2018 Dec ;43(12):2435-2445. Epub 2018 Nov 16. PMID: 30446968 Abstract Title: Isoliquiritigenin Provides Protection and Attenuates Oxidative Stress-Induced Injuries via the Nrf2-ARE Signaling Pathway After Traumatic Brain Injury. Abstract: Traumatic brain injury (TBI) is a serious public health and medical problem worldwide. Oxidative stress plays a vital role in the pathogenesis of …
Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y.
PMID: Chem Biol Interact. 2019 Feb 1 ;299:77-87. Epub 2018 Nov 28. PMID: 30502331 Abstract Title: Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y. Abstract: Neuroblastoma is a common childhood cancer with high mortality. We evaluated the capacity of the flavonoid, isoliquiritigenin (4,2',4'-trihydroxychalcone; ISL) to inhibit cellular proliferation …
Plastic teabags release billions of microparticles and nanoparticles into tea.
PMID: Environ Sci Technol. 2019 Sep 25. Epub 2019 Sep 25. PMID: 31552738 Abstract Title: Plastic Teabags Release Billions of Microparticles and Nanoparticles into Tea. Abstract: The increasing presence of micro- and nano-sized plastics in the environment and food chain is of growing concern. Although mindful consumers are promoting the reduction of single-use plastics, some …
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These results showed that isoliquiritigenin could alleviate lipopolysaccharide-induced septic acute kidney injury.
PMID: Am J Transl Res. 2018 ;10(12):4141-4151. Epub 2018 Dec 15. PMID: 30662657 Abstract Title: Isoliquiritigenin attenuates LPS-induced AKI by suppression of inflammation involving NF-κB pathway. Abstract: Septic acute kidney injury (AKI) characterized as acute infection and renal inflammation, still lacks of effective therapies. Isoliquiritigenin (ISL) as a small molecular from licorice, is able to …
Mechanisms underlying isoliquiritigenin-induced apoptosis and cell cycle arrest in human hepatocellular carcinoma cells.
PMID: Drug Dev Res. 2019 06 ;80(4):461-470. Epub 2019 Jan 30. PMID: 30698296 Abstract Title: Mechanisms underlying isoliquiritigenin-induced apoptosis and cell cycle arrest via ROS-mediated MAPK/STAT3/NF-κB pathways in human hepatocellular carcinoma cells. Abstract: Isoliquiritigenin (ISL), a natural flavonoid isolated from plant licorice, has various pharmacological properties, including anticancer, anti-inflammatory, and antiviral effects. However, the underlying …
Isoliquiritigenin inhibits the proliferation, apoptosis and migration of osteosarcoma cells.
PMID: Oncol Rep. 2019 Apr ;41(4):2502-2510. Epub 2019 Feb 4. PMID: 30720124 Abstract Title: Isoliquiritigenin inhibits the proliferation, apoptosis and migration of osteosarcoma cells. Abstract: The overall survival rate of patients with osteosarcoma has remained unchanged for the last several decades. Therefore, novel drugs for osteosarcoma treatment are required. Isoliquiritigenin (ISL), a natural compound, has …
Isoliquiritigenin attenuates neuroinflammation in traumatic brain injury.
PMID: Neuroimmunomodulation. 2019 ;26(2):102-110. Epub 2019 Feb 15. PMID: 30783039 Abstract Title: Isoliquiritigenin Attenuates Neuroinflammation in Traumatic Brain Injury in Young Rats. Abstract: OBJECTIVES: Inflammation and apoptosis play a critical role in the pathological progress of traumatic brain injury (TBI). Isoliquiritigenin is a bioactive component extracted from licorice roots, which possesses anti-inflammatory and anti-apoptotic properties. …
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Isoliquiritigenin induces mitochondrial dysfunction and apoptosis in A375 human melanoma cells.
PMID: Oxid Med Cell Longev. 2019 ;2019:9817576. Epub 2019 Jan 21. PMID: 30805086 Abstract Title: Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells. Abstract: The mitochondrial protein mitoNEET is a type of iron-sulfur protein localized to the outer membrane of mitochondria and is …
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