PMID: Eur J Pharmacol. 2019 Aug 5 ;856:172352. Epub 2019 Apr 17. PMID: 31004603 Abstract Title: Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma. Abstract: Nasopharyngeal Carcinoma is limited by the various severe side-effects and surgery is rarely performed. Iosliquiritigenin has a series of biological activities, such as antiviral, anti-free radical …
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Harmine might have potential in curing human bladder tumor.
PMID: Biosci Rep. 2019 May 31 ;39(5). Epub 2019 May 2. PMID: 30910851 Abstract Title: Harmine suppresses bladder tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Abstract: Angiogenesis is a vital step during the process of oncogenesis of a lot of tumors, with no exception in bladder cancer. One of the useful …
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Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation.
PMID: Phytomedicine. 2019 Aug ;61:152842. Epub 2019 Jan 30. PMID: 31048127 Abstract Title: Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation. Abstract: BACKGROUND: Parkinson's disease (PD) is an age-dependent progressive movement disorder characterized by a profound and selective loss of nigrostriatal dopaminergic neurons. Accumulation of-synuclein (-syn) positive protein aggregates in the …
Harmine shows therapeutic activity on nicotine-induced liver failure in mice.
PMID: Histol Histopathol. 2019 May 3:18122. Epub 2019 May 3. PMID: 31049922 Abstract Title: Harmine shows therapeutic activity on Nicotine-induced liver failure in mice. Abstract: This experiment evaluated the effects of harmine against nicotine-induced damage to the liver of mice. Nicotine is a major toxic component of cigarette smoke and a major risk factor for …
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β-carbolines are multi-target antidepressant compounds and may be useful in the treatment of depressive disorders.
PMID: Fitoterapia. 2019 Sep ;137:104196. Epub 2019 Jun 6. PMID: 31175948 Abstract Title: Pre-clinical investigations ofβ-carboline alkaloids as antidepressant agents: A systematic review. Abstract: Depressive disorders remain a current public health problem whose prevalence has increased in the past decades. In the constant search for new therapeutic alternatives,β-carboline alkaloids have been identified as good candidates …
This study demonstrates that there is a risk of damage to trees surrounding mobile phone base stations, possibly due to radiofrequency emissions.
n/a PMID: Sci Total Environ. 2016 Dec 1 ;572:554-569. Epub 2016 Aug 24. PMID: 27552133 Abstract Title: Radiofrequency radiation injures trees around mobile phone base stations. Abstract: In the last two decades, the deployment of phone masts around the world has taken place and, for many years, there has been a discussion in the scientific …
Harmine suppresses hyper-activated Ras-MAPK pathway by selectively targeting oncogenic mutated Ras/Raf.
PMID: Cancer Cell Int. 2019 ;19:159. Epub 2019 Jun 11. PMID: 31198408 Abstract Title: Harmine suppresses hyper-activated Ras-MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in. Abstract: Background: Mutationally activated Ras proteins are closely linked to a wide variety of human cancers. Hence, there has been an intensive search for anti-Ras therapies for cancer treatment. …
Harmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment.
PMID: Onco Targets Ther. 2019 ;12:4585-4593. Epub 2019 Jun 12. PMID: 31354292 Abstract Title: Harmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment. Abstract: Purpose: Pancreatic carcinoma is one of the most deadliest types of cancer, and relatively insensitive to the currently available chemotherapy. Thus, the discovery of novel …
It seems that harmine administration improved kidney injury induced by nicotine.
PMID: Int J Prev Med. 2019 ;10:97. Epub 2019 Jun 7. PMID: 31360344 Abstract Title: Effect of Harmine on Nicotine-Induced Kidney Dysfunction in Male Mice. Abstract: Background: The nicotine content of cigarettes plays a key role in the pathogenesis of kidney disease. Harmine is a harmal-derived alkaloid with antioxidant properties. This study was designed to …
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Harmine induces anticancer activity in breast cancer cells via targeting TAZ.
PMID: Int J Oncol. 2019 Jun ;54(6):1995-2004. Epub 2019 Apr 9. PMID: 31081045 Abstract Title: Harmine induces anticancer activity in breast cancer cells via targeting TAZ. Abstract: Harmine (HM) is aβ‑carboline alkaloid found in multiple medicinal plants. It has been used in folk medicine for anticancer therapy; however, the molecular mechanism of HM on human …
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