The results of this study showed the therapeutic potential of cyanidin for the treatment of renal cell carcinoma and the prevention of recurrence and metastasis.

PMID:  Cell Physiol Biochem. 2018 ;46(6):2517-2531. Epub 2018 May 5. PMID: 29742507 Abstract Title:  Cyanidin Curtails Renal Cell Carcinoma Tumorigenesis. Abstract:  BACKGROUND/AIMS: Cyanidin is an anthocyanin found in many foods. Although its variable antioxidant levels are well-documented, little is known about its effects on renal cell carcinoma (RCC) tumorigenesis. This study, therefore, investigated the effects …

Liquiritigenin reduces blood glucose level and bone adverse effects in hyperglycemia.

PMID:  Nutrients. 2019 May 9 ;11(5). Epub 2019 May 9. PMID: 31075971 Abstract Title:  Liquiritigenin Reduces Blood Glucose Level and Bone Adverse Effects in Hyperglycemic Adult Zebrafish. Abstract:  Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia that induces other pathologies including diabetic retinopathy and bone disease. Adult(zebrafish) represents a powerful model to study …

Liquiritigenin has the potential for effective treatment of liver fibrosis.

PMID:  Phytomedicine. 2018 Dec 10 ;62:152780. Epub 2018 Dec 10. PMID: 31121384 Abstract Title:  Liquiritigenin inhibits hepatic fibrogenesis and TGF-β1/Smad with Hippo/YAP signal. Abstract:  BACKGROUND: Recent reports highlighted the possibility that Yes-associated protein (YAP) and transforming growth factor-β1 (TGF-β1) can act as critical regulators of hepatic stellate cells (HSCs) activation; therefore, it is natural for …

Liquiritigenin alleviated cyclophosphamide-induced liver sinusoidal endothelial injury and inflammatory injury.

PMID:  Eur J Pharmacol. 2019 Aug 5 ;856:172421. Epub 2019 May 25. PMID: 31136760 Abstract Title:  The involvement of DAMPs-mediated inflammation in cyclophosphamide-induced liver injury and the protection of liquiritigenin and liquiritin. Abstract:  Cyclophosphamide (CPA) is a chemotherapeutic drug widely used in the treatment of breast cancer or leukemia in clinic. However, CPA was reported …

Liquiritigenin inhibits IL-1β-induced inflammation and cartilage matrix degradation in rat chondrocytes.

PMID:  Eur J Pharmacol. 2019 Sep 5 ;858:172445. Epub 2019 Jun 15. PMID: 31211985 Abstract Title:  Liquiritigenin inhibits IL-1β-induced inflammation and cartilage matrix degradation in rat chondrocytes. Abstract:  Osteoarthritis (OA) is an age-related arthropathy which has been considered to be associated with inflammatory damage and cartilage degradation. Liquiritigenin (LG), the main bioactive component of the …

Exploring common culinary herbs and spices as potential anti-quorum sensing agents.

PMID:  Nutrients. 2019 Mar 29 ;11(4). Epub 2019 Mar 29. PMID: 30934945 Abstract Title:  Exploring Common Culinary Herbs and Spices as Potential Anti-Quorum Sensing Agents. Abstract:  Quorum sensing controls bacterial pathogenesis and virulence; hence, interrupting this system renders pathogenic bacteria non-virulent, and presents a novel treatment for various bacterial infections. In the search for novel …

Anti-inflammatory effect of hydrolyzed celery leaves extract in murine primary splenocyte.

PMID:  J Food Biochem. 2019 Sep ;43(9):e12970. Epub 2019 Jul 18. PMID: 31489653 Abstract Title:  Anti-inflammatory effect of hydrolyzed celery leaves extract in murine primary splenocyte. Abstract:  Apium graveolens (celery) has been used in traditional medicine for the treatment of various ailments. However, its molecular mechanism of action in inflammatory response is unclear. In this …

Apium greaveolens extract treatment can have an analgesic effect in horses affected by chronic osteoarthritic diseases.

PMID:  Animals (Basel). 2019 Aug 20 ;9(8). Epub 2019 Aug 20. PMID: 31434330 Abstract Title:  Clinical Effects of the Extract of the Seeds of the Indian Celery–In Horses Affected by Chronic Osteoarthritis. Abstract:  The extract of the seeds from Indian celery,(CSE), tested in experimental animals (rodents), and in humans affected by chronic osteoarthritic diseases, exhibits …

Effects of aqueous celery extract on lipid parameters of rats fed a high fat diet.

PMID:  Planta Med. 1995 Feb ;61(1):18-21. PMID: 7700983 Abstract Title:  Effects of aqueous celery (Apium graveolens) extract on lipid parameters of rats fed a high fat diet. Abstract:  The antihyperlipidemic property of aqueous celery extract was studied in rats. Two groups of Wistar rats were fed a high fat diet for eight weeks to induce …

An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties.

PMID:  J Pharm Pharmacol. 2007 Jun ;59(6):891-7. PMID: 17637182 Abstract Title:  An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties. Abstract:  Flavonoids, natural compounds widely distributed in the plant kingdom, are reported to affect the inflammatory process and to possess anti-inflammatory as well as immunomodulatory activity …

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