PMID: Chem Biol Interact. 2019 Sep 1 ;310:108728. Epub 2019 Jun 27. PMID: 31254498 Abstract Title: Promotion of mitochondrial protection by naringenin in methylglyoxal-treated SH-SY5Y cells: Involvement of the Nrf2/GSH axis. Abstract: Disruption of the mitochondrial function has been associated with redox impairment and triggering of cell death in nucleated human cells, as observed in …
Category Archives: Uncategorized
Ingestion of 150 to 900mg doses of naringenin is safe in healthy adults, and serum concentrations are proportional to the dose administered.
PMID: Diabetes Obes Metab. 2019 Aug 29. Epub 2019 Aug 29. PMID: 31468636 Abstract Title: Safety and Pharmacokinetics of Naringenin: A Randomized, Controlled, Single Ascending Dose, Clinical Trial. Abstract: AIMS: This study evaluated the safety and pharmacokinetics of naringenin in healthy adults, consuming a whole orange (Citrus Sinensis) extract.METHODS: In a single ascending dose randomized …
This study showed the potential use of naringenin as adjunct in managing the diabetic condition during late presentation.
PMID: Drug Discov Ther. 2019 ;13(4):212-221. PMID: 31534073 Abstract Title: Effects of naringenin on vascular changes in prolonged hyperglycaemia in fructose-STZ diabetic rat model. Abstract: Chronic uncontrolled hyperglycaemia leads to increased oxidative stress and lipid peroxidation resulting in vascular complications and accelerates the progression of diabetic atherosclerosis. Though varieties of modern drugs used in the …
Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein.
PMID: Toxicol In Vitro. 2019 Sep 5 ;61:104642. Epub 2019 Sep 5. PMID: 31493543 Abstract Title: Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship. Abstract: Flavonoids are a group of polyphenols ubiquitously present in vegetables, fruits and herbal products, despite various known …
Chemopreventive and anticancer activity of flavonoids and its possibility for clinical use by combining with conventional chemotherapeutic agents.
PMID: Am J Cancer Res. 2019 ;9(8):1517-1535. Epub 2019 Aug 1. PMID: 31497340 Abstract Title: Chemopreventive and anticancer activity of flavonoids and its possibility for clinical use by combining with conventional chemotherapeutic agents. Abstract: Cancer is a diverse class of diseases characterized by uncontrolled cell growth with the potential to invade and spread to other …
Apple peel flavonoid fraction 4 suppresses breast cancer cell growth by cytostatic and cytotoxic mechanisms.
PMID: Molecules. 2019 Sep 13 ;24(18). Epub 2019 Sep 13. PMID: 31540221 Abstract Title: Apple Peel Flavonoid Fraction 4 Suppresses Breast Cancer Cell Growth by Cytostatic and Cytotoxic Mechanisms. Abstract: Many dietary flavonoids possess anti-cancer activities. Here, the effect of apple peel flavonoid fraction 4 (AF4) on the growth of triple-negative (MDA-MB-231, MDA-MB-468), estrogen receptor-positive …
Total flavonoids from sea buckthorn ameliorates lipopolysaccharide/cigarette smoke-induced airway inflammation.
PMID: Phytother Res. 2019 Aug ;33(8):2102-2117. Epub 2019 Jun 17. PMID: 31209984 Abstract Title: Total flavonoids from sea buckthorn ameliorates lipopolysaccharide/cigarette smoke-induced airway inflammation. Abstract: The total flavonoids from sea buckthorn (TFSB) exhibit a potent anti-inflammatory activity; however, the effect of TFSB on respiratory inflammatory disease is not fully known. The present study evaluated the …
Flavonoid glycosides from seeds of Hippophae rhamnoides have α-glucosidase inhibition activity.
PMID: Fitoterapia. 2019 Sep ;137:104248. Epub 2019 Jun 25. PMID: 31247218 Abstract Title: Flavonoid glycosides from seeds of Hippophae rhamnoides subsp. Sinensis withα-glucosidase inhibition activity. Abstract: Hippophae rhamnoides subsp. Sinensis is a famous traditional medicinal plant in Tibet and Mongolia of China. Three novel flavonoid glycosides and ten known analogues were obtained from the seeds …
Sea buckthorn seed oil reduces blood cholesterol and modulates gut microbiota.
PMID: Food Funct. 2019 Sep 1 ;10(9):5669-5681. Epub 2019 Aug 21. PMID: 31433440 Abstract Title: Sea buckthorn seed oil reduces blood cholesterol and modulates gut microbiota. Abstract: Sea buckthorn seed oil (SBSO) has been used as a functional food in the prevention of heart diseases. The present study investigates the effects of SBSO on blood …
Continue reading “Sea buckthorn seed oil reduces blood cholesterol and modulates gut microbiota.”
Aspartame induced a significant decrease in the mean placental weight and the mean thickness of both labyrinth and basal zones.
PMID: Ann Anat. 2019 Jul ;224:133-141. Epub 2019 May 18. PMID: 31108189 Abstract Title: Effect of aspartame on the placenta of adult albino rat. A histological and immunohistochemical study. Abstract: Aspartame is an artificial sweetener usually consumed by hundreds of millions of persons all over the world. Its metabolites can be toxic to many organs …
Health Time 