PMID: Biomed Pharmacother. 2019 Apr ;112:108675. Epub 2019 Feb 16. PMID: 30780108 Abstract Title: Mulberry leaf active components alleviate type 2 diabetes and its liver and kidney injury in db/db mice through insulin receptor and TGF-β/Smads signaling pathway. Abstract: Mulberry leaf is one of the commonly used traditional Chinese medicines, has been shown to exert …
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Mulberry is a promising therapeutic candidate for constipation.
PMID: Food Funct. 2019 Mar 20 ;10(3):1513-1528. PMID: 30785176 Abstract Title: Protective effect of mulberry (Morus atropurpurea) fruit against diphenoxylate-induced constipation in mice through the modulation of gut microbiota. Abstract: Mulberry (Morus atropurpurea) has long been used to treat gastro-intestinal ailments; however, the functional basis of its therapeutic effects remains unclear. The aim of this …
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Antiproliferative activity of stilbene derivatives and other constituents from the stem bark of Morus nigra L.
PMID: Nat Prod Res. 2019 Mar 1:1-8. Epub 2019 Mar 1. PMID: 30822142 Abstract Title: Antiproliferative activity of stilbene derivatives and other constituents from the stem bark of Morus nigra L. Abstract: The antiproliferative activities of 2',3,4',5,5'-pentahydroxy-cis-stilbene 1, resveratrol 2, oxyresveratrol 3, norartocarpetin 4, kuwanon C 5, morusin 6, cudraflavone A7, kuwanon G 8, albafuran …
Antimicrobial mechanism of reaction products of Morus notabilis polyphenol oxidases and chlorogenic acid.
PMID: Phytochemistry. 2019 Jul ;163:1-10. Epub 2019 Apr 8. PMID: 30974396 Abstract Title: Antimicrobial mechanism of reaction products of Morus notabilis (mulberry) polyphenol oxidases and chlorogenic acid. Abstract: Herein, five polyphenol oxidases (PPOs) obtained from Morus notabilis (Mn) were characterized. Chlorogenic acid was the most readily oxidized substrate by these MnPPOs, and the products derived …
Mulberry fruit exerts anti-inflammatory effects by inhibiting several mediators and cytokines involved in the inflammatory process.
PMID: Molecules. 2019 Apr 11 ;24(7). Epub 2019 Apr 11. PMID: 30978947 Abstract Title: Anti-Inflammatory Effects of High Hydrostatic Pressure Extract of Mulberry () Fruit on LPS-Stimulated RAW264.7 Cells. Abstract: Mulberry fruit (L.) contains abundant bioactive compounds, including anthocyanins and flavonols, and has been reported to possess potent beneficial properties including anticancer, antidiabetic, and anti-oxidant …
The root bark of Morus alba L. suppressed the migration of human non-small-cell lung cancer.
PMID: Int J Mol Sci. 2019 May 7 ;20(9). Epub 2019 May 7. PMID: 31067694 Abstract Title: The Root Bark ofL. Suppressed the Migration of Human Non-Small-Cell Lung Cancer Cells through Inhibition of Epithelial⁻Mesenchymal Transition Mediated by STAT3 and Src. Abstract: The root bark ofL. (MA) has been traditionally used for the treatment of various …
A review of the potency of mulberry as natural potent anti-obesity agent in management of obesity.
PMID: Pharmacol Res. 2019 Aug ;146:104341. Epub 2019 Jul 2. PMID: 31276774 Abstract Title: Morus alba (mulberry), a natural potent compound in management of obesity. Abstract: Obesity is defined as body mass index, higher than 30 kg/m, which are associated with diverse diseases including type 2 diabetes, hypertension, coronary diseases, certain cancers, osteoarthritis and dyslipidemia. The …
Flavones from Morus alba are promising lead compounds to treat MRSA-associated infections.
PMID: J Agric Food Chem. 2019 Sep 11 ;67(36):10222-10234. Epub 2019 Sep 3. PMID: 31385700 Abstract Title: Natural Flavones fromagainst Methicillin-Resistantvia Targeting the Proton Motive Force and Membrane Permeability. Abstract: The emergence and rapid spread of methicillin-resistant(MRSA) critically requires alternative therapeutic options. New antibacterial drugs and strategies are urgently needed to combat MRSA-associated infections. Here, …
Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis.
PMID: Biochem Biophys Res Commun. 2019 Sep 11. Epub 2019 Sep 11. PMID: 31521245 Abstract Title: Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis. Abstract: Endothelial dysfunction (ED) is a crucial and initial stage for the development of cardiovascular diseases. Accumulated evidence has demonstrated causative links between cigarette smoke (CS) and ED. …
Melatonin increases the sensitivity of hepatocellular carcinoma to sorafenib.
PMID: Int J Biol Sci. 2019 ;15(9):1905-1920. Epub 2019 Jul 21. PMID: 31523192 Abstract Title: Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway. Abstract: The mechanisms of resistance to the targeted drug sorafenib in the treatment of hepatocellular carcinoma (HCC) are poorly understood. The purpose of this study was to …
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