Cancer has surpassed heart disease as the No. 1 cause of death in high-income countries, highlighting the urgent need to change the way this disease is prevented and treated
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Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis.
PMID: Transl Psychiatry. 2019 Aug 22 ;9(1):203. Epub 2019 Aug 22. PMID: 31439831 Abstract Title: Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis. Abstract: Accumulating evidence points towards the antipsychotic potential of cannabidiol. However, the neurocognitive mechanisms underlying the antipsychotic effect of cannabidiol remain unclear. We investigated …
Cannabis was associated with a decreased risk of Clostridioides difficile Infection amongst hospitalized patients.
PMID: Anaerobe. 2019 Sep 4:102095. Epub 2019 Sep 4. PMID: 31493498 Abstract Title: Cannabis use and risk of Clostridioides difficile infection: Analysis of 59,824 hospitalizations. Abstract: BACKGROUND: The prevalence of Clostridioides difficile Infection (CDI), the most notorious hospital acquired disease, and of excessive cannabis use (cannabis use disorder (CUD)) have both been steadily rising. Although …
Cannabidiol improves metabolic dysfunction in middle-aged diabetic rats submitted to a chronic cerebral hypoperfusion.
PMID: Chem Biol Interact. 2019 Sep 6:108819. Epub 2019 Sep 6. PMID: 31499052 Abstract Title: Cannabidiol improves metabolic dysfunction in middle-aged diabetic rats submitted to a chronic cerebral hypoperfusion. Abstract: Cannabidiol (CBD), a compound obtained from Cannabis sativa, has wide range of therapeutic properties, including mitigation of diabetes and neurodegeneration. Cerebral ischemia and consequent learning …
Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice.
PMID: J Clin Invest. 2019 Sep 10. Epub 2019 Sep 10. PMID: 31503547 Abstract Title: Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice. Abstract: Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, lack of speech, ataxia, EEG abnormalities, and epilepsy. Seizures in AS individuals are common, debilitating, and often …
Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1.
PMID: Redox Biol. 2019 Sep 5 ;28:101321. Epub 2019 Sep 5. PMID: 31518892 Abstract Title: Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Abstract: Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that attracted a great attention for its therapeutic potential against different pathologies including skin diseases. However, although the efficacy in preclinical models and …
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CBD differentially regulated basal pro-inflammatory response and attenuated both LPS-induced cytokine release and NF-κB activity in monocytes.
PMID: Toxicol Appl Pharmacol. 2019 Aug 19:114713. Epub 2019 Aug 19. PMID: 31437494 Abstract Title: Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts. Abstract: INTRODUCTION: Cannabidiol (CBD) containing products are available in a plethora of flavors including oral, sublingual, and inhalable forms. Immunotoxicological effects of CBD containing liquids …
Huaier polysaccharide may be a potential drug for preventing cisplatin-induced renal damage.
PMID: Int J Biol Macromol. 2019 Aug 1 ;139:932-943. Epub 2019 Aug 1. PMID: 31377293 Abstract Title: A polysaccharide from Huaier ameliorates cisplatin nephrotoxicity by decreasing oxidative stress and apoptosis via PI3K/AKT signaling. Abstract: Cisplatin (CP), a common chemotherapy drug used in treatment of malignant tumors. Due to various side effects such as nephrotoxicity (kidney …
Huaier polysaccharide inhibits the stem-like characteristics triple negative breast cancer cells.
PMID: Int J Biol Sci. 2019 ;15(7):1358-1367. Epub 2019 May 20. PMID: 31337967 Abstract Title: Huaier polysaccharide inhibits the stem-like characteristics of ERα-36triple negative breast cancer cells via inactivation of the ERα-36 signaling pathway. Abstract: Triple negative breast cancer (TNBC) is a highly aggressive cancer and lack of targeting therapies. It is believed that the …
Huaier may act as an effective agent for treating renal cell carcinoma.
PMID: Pharmacology. 2018 ;102(5-6):316-323. Epub 2018 Oct 8. PMID: 30296782 Abstract Title: The Anticancer Effect of Huaier Extract in Renal Cancer 786-O Cells. Abstract: BACKGROUND: Trametes robiniophila Murr (Huaier) has been used as an adjuvant therapy of tumor in traditional Chinese medicine for many years, but the underlying mechanisms are largely unknown. In the present …
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