PMID: PLoS One. 2015 ;10(11):e0142259. Epub 2015 Nov 11. PMID: 26559811 Abstract Title: Genotoxicity Induced by Foetal and Infant Exposure to Magnetic Fields and Modulation of Ionising Radiation Effects. Abstract: BACKGROUND: Few studies have investigated the toxicity and genotoxicity of extremely low frequency magnetic fields (ELF-MF) during prenatal and neonatal development. These phases of life …
Category Archives: Uncategorized
Piperlongumine induces apoptosis and synergizes with doxorubicin in triple-negative breast cancer.
PMID: Molecules. 2019 Jun 25 ;24(12). Epub 2019 Jun 25. PMID: 31242627 Abstract Title: Piperlongumine Induces Apoptosis and Synergizes with Doxorubicin by Inhibiting the JAK2-STAT3 Pathway in Triple-Negative Breast Cancer. Abstract: Triple-negative breast cancer (TNBC) lacks major effective target molecules and chemotherapy remains the current main treatment. However, traditional chemotherapy drugs, such as doxorubicin (DOX), …
The synergistic effects of oxaliplatin and piperlongumine on colorectal cancer are mediated by oxidative stress.
PMID: Cell Death Dis. 2019 Aug 8 ;10(8):600. Epub 2019 Aug 8. PMID: 31395855 Abstract Title: The synergistic effects of oxaliplatin and piperlongumine on colorectal cancer are mediated by oxidative stress. Abstract: Oxaliplatin-based chemotherapy is recommended as the first-line therapeutic regimen for metastatic colorectal cancer. However, long-term and repeated oxaliplatin therapy leads to drug resistance …
Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway.
PMID: Int J Mol Med. 2019 Aug 23. Epub 2019 Aug 23. PMID: 31485612 Abstract Title: Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway. Abstract: Biliary cancer (BC) is an aggressive neoplasm with high mortality. BC can be categorized into three groups: Intrahepatic cholangiocarcinoma (CCA; also known as bile duct …
Piperlongumine reduces ovalbumin‑induced asthma and airway inflammation by regulating nuclear factor‑κB activation.
PMID: Int J Mol Med. 2019 Aug 21. Epub 2019 Aug 21. PMID: 31485644 Abstract Title: Piperlongumine reduces ovalbumin‑induced asthma and airway inflammation by regulating nuclear factor‑κB activation. Abstract: Asthma is a common chronic airway inflammatory disease, characterized by airway inflammation and remodeling. Piperlongumine (PL) has a number of physiological and pharmacological properties. However, the …
Piperlongumine potentiates the antitumor efficacy of oxaliplatin through ROS induction in gastric cancer cells.
PMID: Cell Oncol (Dordr). 2019 Sep 6. Epub 2019 Sep 6. PMID: 31493144 Abstract Title: Piperlongumine potentiates the antitumor efficacy of oxaliplatin through ROS induction in gastric cancer cells. Abstract: PURPOSE: Oxaliplatin is one of the most commonly used chemotherapeutic agents in the treatment of various cancers, including gastric cancer. It has, however, a narrow …
The present study demonstrated that piperlongumine exhibits the antidepressant-like effects.
PMID: Behav Pharmacol. 2019 Sep 9. Epub 2019 Sep 9. PMID: 31503069 Abstract Title: Piperlongumine produces antidepressant-like effects in rats exposed to chronic unpredictable stress. Abstract: Piperlongumine, an alkaloid compound extracted from Peper longum L, has been reported to produce neuroprotective effects in the brain and exert various pharmacological activities such as antitumor, antiangiogenic, anti-inflammatory …
Monoterpene glycosides with anti-inflammatory activity from Paeoniae Radix.
PMID: Fitoterapia. 2019 Aug 6 ;138:104290. Epub 2019 Aug 6. PMID: 31398448 Abstract Title: Monoterpene glycosides with anti-inflammatory activity from Paeoniae Radix. Abstract: Six new monoterpene glycosides, named 6'-O-nicotinoylalbiflorin (1), 4'-O-vanillylalbiflorin (2), paeonidanin L (3), paeoniflorigenin-1-O-β-d-xyloside (4), 6'-(2-hydroxypropanoyl)-paeoniflorin (5), oxylactiflorin (6), together with 16known ones (7-22) were isolated from the 70% ethanol extract of Paeoniae …
Continue reading “Monoterpene glycosides with anti-inflammatory activity from Paeoniae Radix.”
Paeoniflorin has potential as a therapeutic agent against inflammatory bowel disease.
PMID: Inflammation. 2019 Aug 31. Epub 2019 Aug 31. PMID: 31473900 Abstract Title: Paeoniflorin Prevents Intestinal Barrier Disruption and Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in Caco-2 Cell Monolayers. Abstract: Inflammatory bowel disease (IBD) in humans is closely related to bacterial infection and the disruption of the intestinal barrier. Paeoniflorin (PF), a bioactive compound from Paeonia lactiflora …
Beta-elemene can modulate multiple molecular pathways involved in carcinogenesis.
PMID: Nutr Cancer. 2019 Aug 7:1-14. Epub 2019 Aug 7. PMID: 31387393 Abstract Title: Multi-Targeting by-Elemene and Its Anticancer Properties: A Good Choice for Oncotherapy and Radiochemotherapy Sensitization. Abstract: Several studies have focused on chemical agents, tailored from natural edible products, used to prevent and treat various diseases.β-elemene is a well-known compound derived fromthat possesses …
Continue reading “Beta-elemene can modulate multiple molecular pathways involved in carcinogenesis.”
Health Time 