PMID: J Virol. 2012 Jan ;86(1):615-20. Epub 2011 Nov 9. PMID: 22072778 Abstract Title: Recent mumps outbreaks in vaccinated populations: no evidence of immune escape. Abstract: Recently, numerous large-scale mumps outbreaks have occurred in vaccinated populations. Clinical isolates sequenced from these outbreaks have invariably been of genotypes distinct from those of vaccine viruses, raising concern …
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Anthocyanins, delphinidin-3-O-glucoside and cyanidin-3-O-glucoside, inhibit immune checkpoints in human colorectal cancer cells.
PMID: Sci Rep. 2019 Aug 9 ;9(1):11560. Epub 2019 Aug 9. PMID: 31399602 Abstract Title: Anthocyanins, delphinidin-3-O-glucoside and cyanidin-3-O-glucoside, inhibit immune checkpoints in human colorectal cancer cells in vitro and in silico. Abstract: The objective was to assess anti-progression and stimulatory immune response effects among anthocyanins (ANC) and their metabolites on human colorectal cancer cells in …
According to this in-depth statistical analysis, the authors conclude that of the decline in mortality rate in the 1900s, only about 3.5% can be attributed to medical interventions like vaccines.
PMID: Milbank Mem Fund Q Health Soc. 1977 ;55(3):405-28. PMID: 413067 Abstract Title: The questionable contribution of medical measures to the decline of mortality in the United States in the twentieth century. Abstract: [No Abstract] read more
Subclinical pertussis infection, which results from the vaccine’s failure to produce mucosal immunity and prevent infection and transmission, is believed to be a direct cause of MS via impaired immunity to pertussis, which is a neurotoxin.
PMID: Immunobiology. 2016 Apr ;221(4):512-5. Epub 2015 Dec 18. PMID: 26724970 Abstract Title: The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis. Abstract: It is established that (1) subclinical Bordetella pertussis colonization of the nasopharynx persists in highly vaccinated populations, and (2) B. pertussis toxin is a potent adjuvant that, …
Antidiabetic and antioxidative potential of the blue congo variety of purple potato extract.
PMID: Molecules. 2019 Aug 28 ;24(17). Epub 2019 Aug 28. PMID: 31466303 Abstract Title: Antidiabetic and Antioxidative Potential of the Blue Congo Variety of Purple Potato Extract in Streptozotocin-Induced Diabetic Rats. Abstract: This study was designed to evaluate the effects of purple potato extract of the Blue Congo variety (PP) on diabetes and its antioxidant …
A review of dietary anthocyanins and human health.
PMID: Nutrients. 2019 Sep 5 ;11(9). Epub 2019 Sep 5. PMID: 31491856 Abstract Title: Dietary Anthocyanins and Human Health. Abstract: Anthocyanins may contribute to the inverse relationship between fruit and vegetable intake and chronic disease. Anthocyanins are pigments found in plant structures that consist of an anthocyanidin (aglycone) attached to sugar moieties. Anthocyanins may be …
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Parthenolide ameliorates obesity and obesity-induced inflammatory responses.
PMID: Pharmacol Res. 2019 Jul ;145:104259. Epub 2019 May 9. PMID: 31078744 Abstract Title: Parthenolide, a feverfew-derived phytochemical, ameliorates obesity and obesity-induced inflammatory responses via the Nrf2/Keap1 pathway. Abstract: Parthenolide (PL) is one of the most abundant sesquiterpene lactones found in the plant feverfew (Tanacetum parthenium (L.) Sch.Bip.). PL was investigated for its effect on …
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Parthenolide covalently targets and inhibits focal adhesion kinase in breast cancer cells.
PMID: Cell Chem Biol. 2019 Jul 18 ;26(7):1027-1035.e22. Epub 2019 May 9. PMID: 31080076 Abstract Title: Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells. Abstract: Parthenolide, a natural product from the feverfew plant and member of the large family of sesquiterpene lactones, exerts multiple biological and therapeutic activities including anti-inflammatory and …
Parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathway in C2C12 myoblasts.
PMID: J Cell Biochem. 2019 Sep ;120(9):15695-15708. Epub 2019 May 29. PMID: 31144365 Abstract Title: Parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathway in C2C12 myoblasts. Abstract: Muscle redox disturbances and oxidative stress have emerged as a common pathogenetic mechanism and potential therapeutic intervention in some muscle diseases. Parthenolide (PTL), a …
Novel targeted nano-parthenolide molecule against NF-kB in acute myeloid leukemia.
PMID: Molecules. 2019 Jun 3 ;24(11). Epub 2019 Jun 3. PMID: 31163672 Abstract Title: Novel Targeted Nano-Parthenolide Molecule against NF-kB in Acute Myeloid Leukemia. Abstract: The targeted nano-encapsulation of anticancer drugs can improve drug delivery and the selective targeting of cancer cells. Nuclear factor kappa B (NF-kB) is a regulator for different biological responses, including …
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