PMID:
QJM. 2019 Jun 28. Epub 2019 Jun 28. PMID: 31251364
Abstract Title:
Proton Pump Inhibitor Use and Progression to Major Adverse Renal Events: A Competing Risk Analysis.
Abstract:
BACKGROUND: Proton pump inhibitors (PPIs) are associated with acute tubulointerstitial nephritis and there are reports associating their use with the development of chronic kidney disease (CKD).AIM: To determine if PPI use is associated with major adverse renal events (MARE) in patients with CKD.DESIGN: Observational cohort study comprising patients with CKD attending secondary care renal clinics from 01/01/2006 until 31/12/2016.METHODS: We collated baseline clinical, socio-demographic and biochemical data at start of PPI (PPI group) or study inception (control group). MARE was considered a composite of doubling of creatinine or end stage renal disease. Association between PPI exposure and progression to MARE was assessed by cause-specific hazards competing risk survival analysis.RESULTS: There were 3,824 patients with CKD included in the analyses of whom 1,195 were prescribed a PPI. The PPI group was younger (64.8 vs 67.0 years, p
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