PMID:
Brain Res Bull. 2001 Jun ;55(3):367-74. PMID: 11489344
Abstract Title:
Regional distribution of Hsp70 in the CNS of young and old food-restricted rats following hyperthermia.
Abstract:
We examined the effect of aging on the capacity of the brain to produce heat shock protein (Hsp70) in response to heat stress, using high-powered microwaves (HPM, 2.06 GHz, 2.2 W/cm(2)) to induce hyperthermia for periods so brief that thermoregulatory factors were functionally eliminated as confounding variables. Unanesthetized young (6 months) and old (25 months) male, food-restricted Sprague-Dawley rats were exposed to HPM to induce a mean peak tympanic temperature (T(ty)) of 42.2 degrees C within 30 s. T(ty) returned to