PMID:
Theriogenology. 2019 Sep 27 ;142:138-148. Epub 2019 Sep 27. PMID: 31593881
Abstract Title:
Maternal exposure to bisphenol A during pregnancy interferes ovaries development of F1 female mice.
Abstract:
This study was conducted to investigate the effects of maternal exposure bisphenol A (BPA) on ovaries development of F1 female mice. The BPA exposure model of pregnant mice was prepared by intragastric administration of BPA at the doses of 0, 2.5, 5, 10, 20, 40 mg kg dat gestation day (GD) 0.5-17.5. The ovarian index of the offspring mice was calculated at postnatal day (PND) 21 and PND 56. The results showed that BPA at 5 mg/kg, 10 mg/kg, 20 mg/kg and 40 mg/kg significantly increased the abortion rate of the pregnant mice, and each dose of BPA significantly reduced the survival rate of the pups (P
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