Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model.

PMID: 

Avicenna J Phytomed. 2019 Nov-Dec;9(6):499-504. PMID: 31763209

Abstract Title: 

Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model.

Abstract: 

Objective: Pumpkin (L.) seed oil mainly consists of saturated and unsaturated fatty acids. Previously, it was reported that oral administration of pumpkin seed oil (PSO) improved hair growth in male pattern alopecia. This study aimed to evaluate hair promoting activity of topical PSO in an animal model.Materials and Methods: Male Swiss mice (25-30 g) were used. Dorsal hair of mice (2 x 2.5 cm) was gently removed. Groups were treated as follows: (A) Intact control (did not receive testosterone) (B) Testosterone solution only (5% w/v); (C) Testosterone (5%) + PSO (5%); (D) Testosterone (5%) + PSO (10%) (E) Testosterone (5%) + minoxidil (2%). Application of drugs (100µl) was done for six days a week, for 3 weeks. Observational and microscopic examinations were performed and results of different groups were compared.Results: Topical application of testosterone significantly (p

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