PMID:
Animal Model Exp Med. 2019 Sep ;2(3):191-200. Epub 2019 Sep 2. PMID: 31773095
Abstract Title:
normalized cimetidine-induced pituitary-testicular dysfunction: Relevance in nutraceutical therapy.
Abstract:
Background: The increasing incidence of chemically induced infertility is both a social threat and a threat to the continuation of life itself. Treatment or management therapy is often expensive. This study investigated the effects of acetone extract of a local plant () in a Wistar rat model of cimetidine-induced pituitary-testicular dysfunction.Methods: Thirty-five male Wistar rats were divided into 7 groups of 5 rats. After a phytochemical screening of an acetone extract of, cimetidine and the extract at three doses, 200, 400 and 600 mg/kg, were orally co-administered to the rats for 28 consecutive days. Comparisons were made (at
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