PMID:
Anticancer Res. 2018 08 ;38(8):4475-4480. PMID: 30061212
Abstract Title:
Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting theβ-catenin Pathway.
Abstract:
BACKGROUND/AIM: Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth in vitro by inducing apoptosis, but the mechanisms underlying the growth inhibitory effects of alpha-santalol are not fully understood. In this study, we demonstrate thatα-santalol treatment targets Wnt/β-catenin pathway to inhibit migration of cultured breast cancer cells.MATERIALS AND METHODS: Migration assays, immunoblotting and immunofluorescence were used to examine the mechanism of action of a-santalol in breast cancer cells.RESULTS: Exposure of MDA-MB 231 and MCF-7 cells toα-santalol resulted in a significant reduction in their migratory potential and wound healing ability. In addition, α-santalol affected the localization of β-catenin from cytosol to nucleus in MDA-MB 231 cells.CONCLUSION: Alpha-santalol inhibited migration of breast cancer cells may be mediated, in part, by targeting Wnt//β-catenin pathway. β-catenin represents an important target of α-santalol's response for future pre-clinical studies.
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