PMID:
Nutrients. 2019 May 22 ;11(5). Epub 2019 May 22. PMID: 31121899
Abstract Title:
Anti-Inflammatory Effect ofExtract onLipopolysaccharide-Stimulated Macrophages and a Periodontitis Rat Model.
Abstract:
, an edible marine brown alga (Laminariaceae), is a rich source of phlorotannins. This study aimed to investigate the anti-inflammatory effect ofethanol extract (ECE, dieckol 10.6%,/) onlipopolysaccharide-stimulated inflammation in RAW 264.7 cells and in ligature-induced periodontitis in rats. The levels of nitric oxide (NO) and prostaglandin Ewere decreased by more than half on treatment with 100μg/mL ECE. Downregulated tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 gene expression confirmed the anti-inflammatory properties of ECE. ECE treatment upregulated heme oxygenase-1 (HO-1) expression by 6.3-fold and increased HO-1/nuclear factor erythroid 2-related factor 2 (Nrf-2) signaling decreased nuclear factor-κB (NF-κB) translocation. ECE administration (400 mg/kg) significantly reduced gingival index, restricted tooth mobility, and prevented alveolar bone loss (
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