The findings suggest that ayahuasca may show potential as an intervention for suicidality.

PMID: 

Front Pharmacol. 2019 ;10:1325. Epub 2019 Nov 19. PMID: 31798447

Abstract Title: 

The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial.

Abstract: 

Suicide is a major public health problem. Given increasing suicide rates and limitations surrounding current interventions, there is an urgent need for innovative interventions for suicidality. Although ayahuasca has been shown to target mental health concerns associated with suicidality (i.e., depression and hopelessness), research has not yet explored the impact of ayahuasca on suicidality. Therefore, we conducted secondary analyses of a randomized placebo-controlled trial in which individuals with treatment-resistant depression were administered one dose of ayahuasca (= 14) or placebo (= 15). Suicidality was assessed by a trained psychiatrist at baseline, as well as 1 day, 2 days, and 7 days after the intervention. A fixed-effects linear mixed model, as well as between and within-groups Cohen'seffect sizes were used to examine changes in suicidality. Controlling for baseline suicidality, we found a significant effect for time (

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