PMID:
Vaccine. 2017 03 1 ;35(9):1216-1226. Epub 2017 Feb 3. PMID: 28162821
Abstract Title:
Safety of live vaccinations on immunosuppressive therapy in patients with immune-mediated inflammatory diseases, solid organ transplantation or after bone-marrow transplantation
Abstract:
BACKGROUND: Live vaccines are generally contraindicated on immunosuppressive therapy due to safety concerns. However, data are limited to corroborate this practice.OBJECTIVES: To estimate the safety of live vaccinations in patients with immune-mediated inflammatory diseases (IMID) or solid organ transplantation (SOT) on immunosuppressive treatment and in patients after bone-marrow transplantation (BMT).DATA SOURCES: A search was conducted in electronic databases (Cochrane, Pubmed, Embase) and additional literature was identified by targeted searches.ELIGIBILITY CRITERIA: Randomized trials, observational studies and case reports.POPULATION: Patients with IMID or SOT on immunosuppressive treatment and BMT patients