Vitamin D deficiency was associated with more active and severe disease in arthritis patients.

PMID: 

J Rheumatol. 2019 Dec 15. Epub 2019 Dec 15. PMID: 31839594

Abstract Title: 

Association between Vitamin D deficiency and disease activity, disability and radiographic progression in early rheumatoid arthritis. The ESPOIR cohort.

Abstract: 

OBJECTIVE: To evaluate the association of baseline serum level of vitamin D (vitD) with disease activity, disability and radiographic damage over the first year in early rheumatoid arthritis (RA).METHODS: Among early arthritis patients included in the ESPOIR cohort, patients with early RA were evaluated. 25OH vitamin D2D3 level was measured at baseline. Baseline associations between vitD level and DAS28-ESR, Health Assessment Questionnaire Disability Index (HAQ-DI) and van der Heijde-modified total Sharp score (mTSS) were assessed. Bivariate analysis was used to assess the association between vitD level and radiographic progression (mTSS increased by≥1 point) or disability (HAQ-DI ≥0.5) over 12 months. Forward stepwise multiple logistic regression was used to evaluate the independent association of baseline variables and outcomes.RESULTS: Among 813 patients with early arthritis, data for 645 RA patients were analyzed. VitD level was

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