PMID:
Diabetes Metab Syndr. 2011 Jul-Sep;5(3):148-52. Epub 2012 Mar 15. PMID: 22813568
Abstract Title:
Shaddock peels (Citrus maxima) phenolic extracts inhibitα-amylase, α-glucosidase and angiotensin I-converting enzyme activities: a nutraceutical approach to diabetes management.
Abstract:
In this study, the interactions of free and bound phenolic-rich extracts from shaddock peels (popular in folklore for the management of diabetes and hypertension) withα-amylase and α-glucosidase (key enzymes linked to type-2 diabetes) and angiotensin I-converting enzyme (ACE) (key enzyme linked to hypertension) were assessed. The free phenolics of shaddock (Citrus maxima) peels were extracted with 80% acetone, while the bound phenolics were extracted from the alkaline and acid hydrolyzed residue with ethyl acetate; and their interaction with the enzymes were assessed. The phenolic extracts inhibited α-amylase, α-glucosidase and ACE enzyme activities in a dose-dependent manner; however, bound phenolics had significantly higher (P
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