PMID:
Curr Med Sci. 2019 Dec ;39(6):920-928. Epub 2019 Dec 16. PMID: 31845223
Abstract Title:
Protective Effects ofα-Lipoic Acid on Vascular Oxidative Stress in Rats with Hyperuricemia.
Abstract:
The aim of the present study was to observe the protective effects ofα-lipoic acid (ALA) on vascular injury in rats with hyperuricemia (HUA). The ALA treatment groups (10, 30 and 90 mg/kg, respectively) were administered with ALA via gavage for 2 weeks. Subsequently, the levels of blood urea nitrogen (BUN), creatinine (CREA), uric acid (UA), total cholesterol (TC),high density lipoprotein-C (HDL-C) and low density lipoprotein-C (LDL-C) were measured; the activities of glutathione peroxidase (GSH-Px), catalase (CAT), malonaldehyde (MDA), superoxide dismutase (SOD) and xanthine oxidase (XOD) were also determined. The thoracic aorta of rats in each experimentalgroup was observed under a light microscope; ultrastructural analysis was performed. SOD and CAT protein contents were investigated by Western blotting. The results revealed that: i) Compared with the model group, the levels of UA were decreased in the ALA groups and the levels of BUN, CREA, TC, andLDL-C decreased in the 30 and 90 mg/kg ALA groups (P
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