PMID:
Saudi J Biol Sci. 2019 Nov ;26(7):1436-1441. Epub 2018 Jun 5. PMID: 31762606
Abstract Title:
Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5' adenosine monophosphate kinase up-regulation.
Abstract:
5' AMP-activated protein kinase (AMPK), insulin receptors and transporters are distorted in diabetes mellitus. In this study, the effect ofwas assessed on glucose manipulating enzymes activities and gene expression of AMPK, IRA and GLUT2 in streptozotocin-induced diabetic male rats. Forty male albino rats were randomly divided to four groups 10 rats of each, group I, normal control group (received saline orally); group II, normal rats received 200 mg/kg oforally; group III, Streptozotocin (STZ) -induced diabetic rats and group IV, STZ-induced diabetic rats received 200 mg/kg oforally. The duration of experiment was 30 days. Results showed the ability ofinduce a significant decrease in the blood glucose and increase in the serum insulin levels, hepatic glucokinase (GK), and glycogen synthase (GS) activities with a modulation of lipid profile besides high expression levels of AMPK, insulin receptor A (IRA), glucose transporting protein-2 (GLUT-2) in liver of diabetic rats. In conclusion, the obtained results point to the ability ofto improve the glucose metabolism in diabetic models.
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