PMID:
Biosci Rep. 2020 Jan 14. Epub 2020 Jan 14. PMID: 31934719
Abstract Title:
Effects of emodin on inflammatory bowel diseases related osteoporosis.
Abstract:
Inflammatory bowel diseases (IBD) are related to bone loss. Emodin can influence the activity and differentiation of osteoblasts and osteoclasts. However, few studies have shown the effects of emodin on IBD-induced bone damage. The aim of this study was to investigate the role of emodin in IBD-induced osteoporosis in an animal model. An IBD model in Sprague-Dawley male rats was established by administering 2.5% DSS in the drinking water. Emodin was administered orally (30 mg/kg body weight) every other day starting in the third week for 9 weeks. Blood, colon and bone samples were obtained for biomarker assays and histological analysis. Bone biomechanical properties, microCT, metabolic biomarkers and bone histological changes were analyzed. The bone mass was significantly decreased, and the bone biomechanical properties and bone microstructure parameters of IBD rats were significantly worse than those of control rats (p
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