Lactobacillus paracasei Jlus66 can improve NAFLD by modulating the intestinal flora and followed reduction of oxidative stress and inflammation.

PMID: 

Food Sci Nutr. 2019 Aug ;7(8):2636-2646. Epub 2019 Jul 15. PMID: 31428351

Abstract Title: 

Jlus66 extenuate oxidative stress and inflammation via regulation of intestinal flora in rats with non alcoholic fatty liver disease.

Abstract: 

The nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that affects the health of people in an increasing rate. In the current research, we investigated the beneficial effect of a novel probiotic strainJlus66 (Jlus66) on rats with high-fat diet (HFD)-induced NAFLD. The intestinal flora of rats was analyzed based on V3-V4 region 16S rDNA sequencing. Moreover, we measured the oxidative stress and inflammation factors in the liver using commercial ELISA kit, and the lipopolysaccharide (LPS) in serum with chromogenic end-point tachypheus amebocyte lysate. Compared with the HFD-induced group, Jlus66 treatment significantly decreased the malondialdehyde (MDA) level in the serum ( 

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