PMID: J Sci Food Agric. 2015 Dec ;95(15):3177-82. Epub 2015 Jan 22. PMID: 25530163 Abstract Title: Diosgenin reorganises hyperglycaemia and distorted tissue lipid profile in high-fat diet-streptozotocin-induced diabetic rats. Abstract: BACKGROUND: Diabetes is often connected with significant morbidity, mortality and also has a pivotal role in the development of cardiovascular diseases. Diet intervention, particularly naturaceutical …
Author Archives: Taylor Mercado
Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury model.
PMID: J Physiol Sci. 2014 Nov ;64(6):393-400. Epub 2014 Aug 24. PMID: 25150984 Abstract Title: Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial KATP channel. Abstract: This study was designed to investigate the anti-arrhythmic effect of diosgenin preconditioning in myocardial reperfusion injury in rat, …
This is the first report of its kind that provides an intense scientific rationale for use of diosgenin as novel candidate for type II diabetes mellitus.
PMID: PLoS One. 2014 ;9(9):e106039. Epub 2014 Sep 12. PMID: 25216353 Abstract Title: Diosgenin from Dioscorea bulbifera: novel hit for treatment of type II diabetes mellitus with inhibitory activity againstα-amylase and α-glucosidase. Abstract: Diabetes mellitus is a multifactorial metabolic disease characterized by post-prandial hyperglycemia (PPHG).α-amylase and α-glucosidase inhibitors aim to explore novel therapeutic agents. Herein …
Role of SB203580 in the regulation of human esophageal cancer cells under the effection of Diosgenin.
PMID: Int J Clin Exp Med. 2015 ;8(2):2476-9. Epub 2015 Feb 15. PMID: 25932192 Abstract Title: Role of SB203580 in the regulation of human esophageal cancer cells under the effection of Diosgenin. Abstract: In order to investigate the mechanism of human esophageal Eca109 cells induced by Diosgenin (Dio), the p38 specific inhibitor SB203580 was used …
Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation.
PMID: Lab Anim Res. 2016 Jun ;32(2):105-15. Epub 2016 Jun 24. PMID: 27382379 Abstract Title: Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection. Abstract: To investigate the beneficial effects of diosgenin (DG) on the multiple types of brain damage induced by …
Diosgenin attenuates the brain injury induced by transient focal cerebral ischemia-reperfusion.
PMID: Steroids. 2016 09 ;113:103-12. Epub 2016 Jul 16. PMID: 27425638 Abstract Title: Diosgenin attenuates the brain injury induced by transient focal cerebral ischemia-reperfusion in rats. Abstract: The aim of the present study is to explore the potential cerebroprotection of diosgenin against the transient focal cerebral ischemia-reperfusion (I/R) injury and its possible underlying mechanisms. The …
Diosgenin rich food can be recommended to diabetic subjects as dietary management to postpone the occurrence of sugar cataract.
PMID: J Diabetes Res. 2017 ;2017:7309816. Epub 2017 Sep 5. PMID: 29038789 Abstract Title: Diosgenin, a Novel Aldose Reductase Inhibitor, Attenuates the Galactosemic Cataract in Rats. Abstract: OBJECTIVE: To seek efficient aldose reductase inhibitors (ARIs) with excellent in vitro and in vivo biological activities against rat galactosemic cataract.METHODS: The method was firstly optimized to screen …
Diosgenin may exhibit utility as an auxiliary treatment for the clinical reduction of metastasis in patients with osteosarcoma.
PMID: Oncol Lett. 2019 Oct ;18(4):4278-4287. Epub 2019 Aug 23. PMID: 31579425 Abstract Title: Diosgenin inhibits the epithelial-mesenchymal transition initiation in osteosarcoma cells via the p38MAPK signaling pathway. Abstract: Diosgenin is an important basic raw material for the production of steroid hormone drugs. It can be isolated and purified from a variety of traditional Chinese …
Effects of diosgenin and its derivatives on atherosclerosis.
PMID: Food Funct. 2019 Nov 1 ;10(11):7022-7036. Epub 2019 Nov 5. PMID: 31687707 Abstract Title: Effects of diosgenin and its derivatives on atherosclerosis. Abstract: Atherosclerosis is one of the leading causes of death in patients with cardiovascular diseases worldwide. Although some progress has been made in the treatment of cardiovascular diseases, the morbidity and mortality …
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Expression of chemokines in macrophage polarization and downregulation of NFκB in aorta allow macrophage polarization by diosgenin in atherosclerosis.
PMID: J Biochem Mol Toxicol. 2019 Nov 15:e22422. Epub 2019 Nov 15. PMID: 31729780 Abstract Title: Expression of chemokines in macrophage polarization and downregulation of NFκB in aorta allow macrophage polarization by diosgenin in atherosclerosis. Abstract: M1 macrophages serve one edge as proinflammatory and M2 macrophages serve the other edge as an anti-inflammatory macrophage. It …
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