PMID: Life Sci. 2020 Jan 15 ;241:117115. Epub 2019 Nov 29. PMID: 31790685 Abstract Title: The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model. Abstract: AIMS: Psoriasis is a cutaneous disease mainly characterized by keratinocyte hyperproliferation, abnormal epidermal differentiation, inflammation and angiogenesis. In this study, we aimed to report …
Author Archives: Taylor Mercado
Diosgenin was found to have efficient antitumor potential of human cholangiocarcinoma cells in vitro and in vivo.
PMID: Onco Targets Ther. 2019 ;12:9093-9104. Epub 2019 Nov 4. PMID: 31806994 Abstract Title: Diosgenin Suppresses Cholangiocarcinoma Cells Via Inducing Cell Cycle Arrest And Mitochondria-Mediated Apoptosis. Abstract: Purpose: Diosgenin (DSG) is the precursor of steroid hormones and plays a crucial part in the proliferation of various carcinomas including human colorectal cancer and gastric carcinoma. Nevertheless, …
This suggests the potential usefulness of diosgenin in treating breast cancer.
PMID: Int J Mol Sci. 2019 Dec 25 ;21(1). Epub 2019 Dec 25. PMID: 31881805 Abstract Title: Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells. Abstract: The anti-tumor activity of diosgenin, a new steroidal constituent present in fenugreek, on …
Continue reading “This suggests the potential usefulness of diosgenin in treating breast cancer.”
The role of diosgenin in diabetes and diabetic complications.
PMID: J Steroid Biochem Mol Biol. 2019 Dec 30 ;198:105575. Epub 2019 Dec 30. PMID: 31899316 Abstract Title: The role of diosgenin in diabetes and diabetic complications. Abstract: Diabetes mellitus is a chronic and common metabolic disease that seriously endangers human health. Hyperglycemia and long-term metabolic disorders in diabetes will cause damage to the whole …
Continue reading “The role of diosgenin in diabetes and diabetic complications.”
Menstrual problems in adolescence: relationship to serum vitamins A and E, and systemic inflammation.
PMID: Arch Gynecol Obstet. 2019 Nov 16. Epub 2019 Nov 16. PMID: 31734759 Abstract Title: Menstrual problems in adolescence: relationship to serum vitamins A and E, and systemic inflammation. Abstract: BACKGROUND: Vitamin status and inflammatory mechanisms may be related to menstrual cycle abnormalities. We investigated the associations between serum fat soluble vitamin (vitamins A and …
Alterations of brain quantitative proteomics profiling revealed the molecular mechanisms of diosgenin against cerebral ischemia reperfusion effects.
PMID: J Proteome Res. 2020 Jan 15. Epub 2020 Jan 15. PMID: 31940440 Abstract Title: Alterations of brain quantitative proteomics profiling revealed the molecular mechanisms of diosgenin against cerebral ischemia reperfusion effects. Abstract: Diosgenin (DIO), the starting material for the synthesis of steroidal anti-inflammatory drugs in pharmaceutical industry, has been previously demonstrated to display pharmaceutical …
Apoptotic, necrotic, and antiproliferative activity of diosgenin and diosgenin glycosides on cervical cancer cells.
PMID: Eur J Pharmacol. 2020 Jan 20:172942. Epub 2020 Jan 20. PMID: 31972180 Abstract Title: Apoptotic, necrotic, and antiproliferative activity of diosgenin and diosgenin glycosides on cervical cancer cells. Abstract: (25R)-spirost-5-en-3β-ol, also known as diosgenin (DSG), exerts antiproliferative activity on diverse cell lines, induces apoptosis, and acts as a chemopreventative agent. However, the relationship between …
A. senticosus polysaccharide has an obvious protective effect on the gut homeostasis of Drosophila melanogaster.
PMID: Phytother Res. 2020 Jan ;34(1):193-200. Epub 2019 Nov 17. PMID: 31736181 Abstract Title: Acanthopanax senticosus polysaccharide regulates the intestinal homeostasis disruption induced by toxic chemicals in Drosophila. Abstract: The intestinal epithelium provides the first line of defense against pathogens and toxic compounds. The ingestion of toxic compounds causes an enhanced epithelial cell death and …
Acanthopanax senticosus polysaccharide suppressed the proliferation and metastasis of the human non-small cell lung cancer NCI-H520 cells.
PMID: Neoplasma. 2019 Jul 23 ;66(4):555-563. Epub 2019 Mar 30. PMID: 30943746 Abstract Title: Acanthopanax senticosus polysaccharide suppressing proliferation and metastasis of the human non-small cell lung cancer NCI-H520 cells is associated with Wnt/β-catenin signaling. Abstract: Lung cancer (LC) is the highest lethality in all tumors. Non-small cell lung cancer (NSCLC) accounts for about 80% …
Eleutherococcus senticosus leaves can play a therapeutic role in treating ischemic stroke through different pathways.
PMID: J Ethnopharmacol. 2019 Sep 15 ;241:111969. Epub 2019 May 22. PMID: 31125596 Abstract Title: Mass spectrometry-based urinary metabolomics for the investigation on the mechanism of action of Eleutherococcus senticosus (Rupr.&Maxim.) Maxim. leaves against ischemic stroke in rats. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: As a traditional Chinese medicine, Eleutherococcus senticosus (Rupr.&Maxim.) Maxim. leaves (ESL) can treat ischemic, …
Health Time 