PMID: Nutr Metab Cardiovasc Dis. 2019 Dec ;29(12):1408-1417. Epub 2019 Aug 14. PMID: 31640890 Abstract Title: The probiotic Lactobacillus fermentum 296 attenuates cardiometabolic disorders in high fat diet-treated rats. Abstract: BACKGROUND AND AIM: High-fat (HF) diet consumption has been associated with gut dysbiosis and increased risk of dyslipidemia, type 2 diabetes mellitus and hypertension. Probiotic …
Author Archives: Taylor Mercado
Scientists Discover New Cannabinoids
Researchers at the University of Salento in Lecce, Italy have discovered two new cannabionoids; THCP and CBDP. THCP is estimated to be even more potent than THC. In tests on mice, researchers found THCP has “an affinity for CB1 receptor more than thirty-fold higher compared to the one reported for THC.” The other newly discovered …
Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders.
PMID: Int J Nanomedicine. 2019 ;14:4449-4460. Epub 2019 Jun 17. PMID: 31417253 Abstract Title: Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders. Abstract: Curcumin as a hydrophobic polyphenol is extracted from the rhizome of. Curcumin is widely used as a dietary spice and a topical medication for the treatment of …
Fermentation with lactic acid bacteria increases the curcumin content of turmeric without increasing its cytotoxicity.
PMID: J Microbiol Biotechnol. 2019 Oct 28 ;29(10):1561-1569. PMID: 31434176 Abstract Title: Effect ofFermentation on the Anti-Inflammatory Potential of Turmeric. Abstract: Curcumin, the major bioactive constituent of turmeric, has been reported to have a wide range of pharmacological benefits; however, the low solubility in water has restricted its systemic bioavailability and therapeutic potential. Therefore, in …
Curcumin attenuates lead-induced neurotoxicity via inhibition of oxidative stress and chelating activity.
PMID: Biomolecules. 2019 Sep 6 ;9(9). Epub 2019 Sep 6. PMID: 31489882 Abstract Title: Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Chelating Activity and Inhibition of Oxidative Stress. Abstract: Lead (Pb) is a toxic, environmental heavy metal that induces serious clinical defects in all organs, with the nervous system being its primary target. Curcumin …
Curcumin and vitamin D3 enhanced the tumor response to paclitaxel.
PMID: Chem Biol Interact. 2019 Oct 16 ;315:108865. Epub 2019 Oct 16. PMID: 31628941 Abstract Title: Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer. Abstract: Treatment of breast cancer by paclitaxel (PAX) often encounters therapeutic failure most likely caused by innate/acquired resistance. Cancer …
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Curcumin downregulates GSK3 and Cdk5 in scopolamine-induced Alzheimer’s disease.
PMID: J Alzheimers Dis Rep. 2019 Aug 30 ;3(1):257-267. Epub 2019 Aug 30. PMID: 31754658 Abstract Title: Curcumin Downregulates GSK3 and Cdk5 in Scopolamine-Induced Alzheimer's Disease Rats Abrogating Aβand Tau Hyperphosphorylation. Abstract: Alzheimer's disease (AD) is the most common form of dementia. Extracellular amyloid-β (Aβ) aggregation and tau hyperphosphorylation are the key drivers of AD. …
Continue reading “Curcumin downregulates GSK3 and Cdk5 in scopolamine-induced Alzheimer’s disease.”
Neuroprotective effects of curcumin through autophagy modulation.
PMID: IUBMB Life. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31804772 Abstract Title: Neuroprotective effects of curcumin through autophagy modulation. Abstract: Autophagy is a highly conserved cellular degradation process involving lysosomal degradation for the turnover of proteins, protein complexes, and organelles. Defects in autophagy produces impaired intercellular communication and have subsequently been shown to …
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Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer.
PMID: Mol Carcinog. 2020 Feb ;59(2):227-236. Epub 2019 Dec 9. PMID: 31820492 Abstract Title: Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer. Abstract: Colorectal cancer (CRC) is associated with significant morbidity and mortality in the US and worldwide. CRC is the second most common cancer-related death in both men and women …
Curcumin has immunomodulatory effects on RANKL-stimulated osteoclastogenesis in vitro and titanium nanoparticle-induced bone loss in vivo.
PMID: J Cell Mol Med. 2019 Dec 17. Epub 2019 Dec 17. PMID: 31845532 Abstract Title: Curcumin has immunomodulatory effects on RANKL-stimulated osteoclastogenesis in vitro and titanium nanoparticle-induced bone loss in vivo. Abstract: Wear particle-stimulated inflammatory bone destruction and the consequent aseptic loosening remain the primary causes of artificial prosthesis failure and revision. Previous studies …
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