Manufacturing issues with a tuberculosis vaccine led to an outbreak of lymphadenitis.

PMID:  Vaccine. 2014 Oct 7 ;32(44):5809-15. Epub 2014 Aug 27. PMID: 25173482 Abstract Title:  Investigations into an outbreak of suppurative lymphadenitis with BCG vaccine SSI(®) in Singapore. Abstract:  INTRODUCTION: From 2011 to 2012, we received an unexpectedly high number of reports of suppurative lymphadenitis following administration of a BCG vaccine used in our childhood vaccination …

Pomegranate peel extract reduced colonic damage and bacterial translocation in a mouse model of infectious colitis induced by Citrobacter rodentium.

n/a PMID:  Nutr Res. 2019 Nov 16 ;73:27-37. Epub 2019 Nov 16. PMID: 31841745 Abstract Title:  Pomegranate peel extract reduced colonic damage and bacterial translocation in a mouse model of infectious colitis induced by Citrobacter rodentium. Abstract:  The pomegranate fruit peel is a rich source of polyphenols including punicalins, punicalagins, and ellagic acids, but is …

This clinical trial reported changes in mental status, mesenteric lympahdenitis, and ileus associated with a dose of a tuberculosis vaccine candidate.

PMID:  Vaccine. 2017 03 14 ;35(12):1652-1661. Epub 2017 Feb 17. PMID: 28216183 Abstract Title:  Safety and immunogenicity of the novel H4:IC31 tuberculosis vaccine candidate in BCG-vaccinated adults: Two phase I dose escalation trials. Abstract:  BACKGROUND: Novel vaccine strategies are required to provide protective immunity in tuberculosis (TB) and prevent development of active disease. We investigated …

Health effects associated with electronic cigarette use: automated mining of online forums.

PMID:  J Med Internet Res. 2020 Jan 3 ;22(1):e15684. Epub 2020 Jan 3. PMID: 31899452 Abstract Title:  Health Effects Associated With Electronic Cigarette Use: Automated Mining of Online Forums. Abstract:  BACKGROUND: Our previous infodemiological study was performed by manually mining health-effect data associated with electronic cigarettes (ECs) from online forums. Manual mining is time consuming …

This study did not find an overall effect of BCG vaccination on antibody levels after pentavalent vaccines given during the first year of life.

PMID:  Vaccine. 2017 04 11 ;35(16):2084-2091. Epub 2017 Mar 15. PMID: 28318766 Abstract Title:  Bacille Calmette-Guérin (BCG) vaccination at birth and antibody responses to childhood vaccines. A randomised clinical trial. Abstract:  INTRODUCTION: BCG vaccination has been associated with beneficial non-specific effects on child health. Some immunological studies have reported heterologous effects of vaccines on antibody …

2090 adverse events involving Tdap were reported between 2005-2007. It is estimated that only 1% of adverse events are reported.

PMID:  Vaccine. 2013 Feb 27 ;31(10):1447-52. Epub 2012 Nov 8. PMID: 23142308 Abstract Title:  U.S. Postlicensure safety surveillance for adolescent and adult tetanus, diphtheria and acellular pertussis vaccines: 2005-2007. Abstract:  BACKGROUND: Pre-licensure clinical trials for two U.S. licensed tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccines did not reveal any major safety concerns. …

Association between E-cigarette use and chronic obstructive pulmonary disease by smoking status.

PMID:  Am J Prev Med. 2019 Dec 28. Epub 2019 Dec 28. PMID: 31902685 Abstract Title:  Association Between E-Cigarette Use and Chronic Obstructive Pulmonary Disease by Smoking Status: Behavioral Risk Factor Surveillance System 2016 and 2017. Abstract:  INTRODUCTION: The association between e-cigarette use and chronic bronchitis, emphysema, and chronic obstructive pulmonary disease has not been …

The Tdap vaccine is so ineffective that lifelong vaccination may be needed to maintain immunity.

PMID:  Eur J Intern Med. 2014 Jul ;25(6):528-32. Epub 2014 May 9. PMID: 24814432 Abstract Title:  Low seroprevalence of diphtheria, tetanus and pertussis in ambulatory adult patients: the need for lifelong vaccination. Abstract:  BACKGROUND: Tetanus, diphtheria, pertussis and measles are vaccine preventable diseases that have been reported to cause morbidity and mortality in adult population …

Among adolescents who received all acellular pertussis vaccines, overall Tdap effectiveness was 63.9%, but after 2-4 years, effectiveness waned to 34%.

PMID:  Pediatrics. 2015 Jun ;135(6):981-9. Epub 2015 May 4. PMID: 25941309 Abstract Title:  Tdap vaccine effectiveness in adolescents during the 2012 Washington State pertussis epidemic. Abstract:  BACKGROUND: Acellular pertussis vaccines replaced whole-cell vaccines for the 5-dose childhood vaccination series in 1997. A sixth dose of pertussis-containing vaccine, tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis, …

There were many cases of microcephaly reported in 2014, attributed to the Brazil Zika outbreak, however, this outbreak also overlapped with Brazil’s initiation of their Tdap program.

PMID:  JAMA. 2016 Nov 1 ;316(17):1823-1825. PMID: 27802536 Abstract Title:  Tdap Vaccination During Pregnancy and Microcephaly and Other Structural Birth Defects in Offspring. Abstract:  [n/a] read more

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