Taylor Mercado

Enhanced anticancer effect of adding magnesium to vitamin C therapy.

PMID: Transl Oncol. 2019 Dec 31 ;13(2):401-409. Epub 2019 Dec 31. PMID: 31901552 Abstract Title: Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation. Abstract: l-Ascorbic acid (vitamin C, AA) is known as an antioxidant, but at high concentrations, AA can kill cancer cells through a prooxidant property. …

Continue reading “Enhanced anticancer effect of adding magnesium to vitamin C therapy.”

Melatonin protects intervertebral disc from degeneration.

PMID: Oxid Med Cell Longev. 2019 ;2019:5120275. Epub 2019 Dec 2. PMID: 31885798 Abstract Title: Melatonin Protects Intervertebral Disc from Degeneration by Improving Cell Survival and Function via Activation of the ERK1/2 Signaling Pathway. Abstract: Melatonin, a neuroendocrine hormone secreted by the pineal body, has a positive effect on intervertebral disc degeneration. The present study …

Continue reading “Melatonin protects intervertebral disc from degeneration.”

Efficacy of melatonin in restoring the antioxidant status in the lens of diabetic rats induced by streptozotocin.

PMID: J Diabetes Metab Disord. 2019 Dec ;18(2):543-549. Epub 2019 Dec 2. PMID: 31890680 Abstract Title: Efficacy of melatonin in restoring the antioxidant status in the lens of diabetic rats induced by streptozotocin. Abstract: Background: Melatonin is a well-known free radical scavenger. The present study aimed to investigate the effects of melatonin treatment on the …

Continue reading “Efficacy of melatonin in restoring the antioxidant status in the lens of diabetic rats induced by streptozotocin.”

Melatonin suppresses epithelial‑to‑mesenchymal transition in the MG‑63 cell line.

PMID: Mol Med Rep. 2019 Dec 23. Epub 2019 Dec 23. PMID: 31894324 Abstract Title: Melatonin suppresses epithelial‑to‑mesenchymal transition in the MG‑63 cell line. Abstract: Epithelial‑to‑mesenchymal transition (EMT) is a major process involved in tumor progression and metastasis. Melatonin is secreted by the pineal gland and has been documented as a potential therapeutic agent for …

Continue reading “Melatonin suppresses epithelial‑to‑mesenchymal transition in the MG‑63 cell line.”

Melatonin rescues osteoporosis by upregulating bone marrow mesenchymal stem cells osteogenic ability.

n/a PMID: Br J Pharmacol. 2020 Jan 3. Epub 2020 Jan 3. PMID: 31900938 Abstract Title: Melatonin rescues osteoporosis by upregulating BMMSCs' osteogenic ability but suppressing BMMSC-mediated osteoclastogenesis via MT2-inactivated NF- Abstract: BACKGROUND AND PURPOSE: Melatonin is a neurohormone involved in many biological activities, especially bone homeostasis. However, how melatonin directs bone remodelling and the …

Continue reading “Melatonin rescues osteoporosis by upregulating bone marrow mesenchymal stem cells osteogenic ability.”

Melatonin may be a promising therapeutic candidate for acute spinal cord injury.

PMID: Neuropeptides. 2019 Dec 25:102002. Epub 2019 Dec 25. PMID: 31902595 Abstract Title: Melatonin exerts neuroprotective effects by attenuating astro- and microgliosis and suppressing inflammatory response following spinal cord injury. Abstract: Reactive gliosis and inflammatory reaction are common pathological change to spinal cord injury (SCI). Whereas, the effects of melatonin (MT) on the astro- and …

Continue reading “Melatonin may be a promising therapeutic candidate for acute spinal cord injury.”

Acute cannabidiol administration at a dose of 300 mg decreased anxiety in patients with Parkinson’s disease.

PMID: J Psychopharmacol. 2020 Jan 7:269881119895536. Epub 2020 Jan 7. PMID: 31909680 Abstract Title: Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson's disease. Abstract: BACKGROUND: Cannabidiol (CBD) is one of the main components ofand has anxiolytic properties, but no study has been conducted …

Continue reading “Acute cannabidiol administration at a dose of 300 mg decreased anxiety in patients with Parkinson’s disease.”

Beta-caryophyllene could be useful for prevention and treatment of antiretroviral-induced neuropathic pain.

PMID: Molecules. 2019 Dec 27 ;25(1). Epub 2019 Dec 27. PMID: 31892132 Abstract Title: β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain. Abstract: Neuropathic pain associated with nucleoside reverse transcriptase inhibitors (NRTIs), therapeutic agents for human immunodeficiency virus (HIV), responds poorly to available drugs. Smoked cannabis was reported …

Continue reading “Beta-caryophyllene could be useful for prevention and treatment of antiretroviral-induced neuropathic pain.”

Smoking as a risk factor of invasive fungal disease: Systematic review and meta-analysis.

PMID: Clin Infect Dis. 2020 Jan 4. Epub 2020 Jan 4. PMID: 31900476 Abstract Title: Smoking as a risk factor of invasive fungal disease: Systematic review and meta-analysis. Abstract: To investigate the association between smoking and invasive fungal disease (IFD), we searched MEDLINE and Web of Science for studies published until September 2018. Two authors …

Continue reading “Smoking as a risk factor of invasive fungal disease: Systematic review and meta-analysis.”

Cycle training induces muscle hypertrophy and strength gain: strategies and mechanisms.

PMID: Acta Physiol Hung. 2015 Mar ;102(1):1-22. PMID: 25804386 Abstract Title: Cycle training induces muscle hypertrophy and strength gain: strategies and mechanisms. Abstract: Cycle training is widely performed as a major part of any exercise program seeking to improve aerobic capacity and cardiovascular health. However, the effect of cycle training on muscle size and strength …

Continue reading “Cycle training induces muscle hypertrophy and strength gain: strategies and mechanisms.”