PMID: Cancer Med. 2019 Dec 31. Epub 2019 Dec 31. PMID: 31891230 Abstract Title: Combined treatment with N-acetylcysteine and gefitinib overcomes drug resistance to gefitinib in NSCLC cell line. Abstract: We aimed to explore the molecular substrate underlying EGFR-TKI resistance and investigate the effects of N-acetylcysteine (NAC) on reversing EGFR-TKI resistance. In the current research, …
Author Archives: Taylor Mercado
These results support the potential use of α-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.
PMID: Nat Prod Bioprospect. 2019 Oct ;9(5):345-349. Epub 2019 Sep 19. PMID: 31538308 Abstract Title: Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells. Abstract: Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps,α-mangostin, has …
Alpha-mangostin ameliorates bleomycin-induced pulmonary fibrosis.
PMID: Front Pharmacol. 2019 ;10:1305. Epub 2019 Nov 13. PMID: 31798444 Abstract Title: Alpha-Mangostin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice Partly Through Activating Adenosine 5'-Monophosphate-Activated Protein Kinase. Abstract: Pulmonary fibrosis (PF) is a devastating interstitial lung disease and characterized by an abnormal accumulation of extracellular matrix (ECM). Nintedanib (NDN) and pirfenidone are two approved therapies …
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Alpha-mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders.
PMID: Aging (Albany NY). 2019 Dec 6 ;11(23):11084-11110. Epub 2019 Dec 6. PMID: 31806859 Abstract Title: α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice. Abstract: Low-grade chronic adipose tissue inflammation contributes to the onset and development of aging-related insulin resistance and type 2 diabetes. In the current study,α-mangostin, a xanthone …
Review xanthones and cancer: from natural sources to mechanisms of action.
PMID: Chem Biodivers. 2019 Dec 3. Epub 2019 Dec 3. PMID: 31794156 Abstract Title: Review Xanthones and Cancer: From Natural Sources to Mechanisms of Action. Abstract: Xanthones are a class of heterocyclic natural products that have been widely studied for their pharmacological potential. In fact, they have been serving as scaffolds for the design of …
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Xanthones protects lead-induced chronic kidney disease.
PMID: Biochem Biophys Rep. 2020 Mar ;21:100718. Epub 2019 Dec 10. PMID: 31886417 Abstract Title: Xanthones protects lead-induced chronic kidney disease (CKD) via activating Nrf-2 and modulating NF-kB, MAPK pathway. Abstract: Xanthones from a tropical fruit ofL. is known to possess a wide spectrum of pharmacologic properties, including antioxidant, anti-bacterial, anti-inflammatory, and antidiabetic activities. The …
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α-Mangostin reduced the viability of A594 cells in vitro by provoking ROS production through downregulation of NAMPT/NAD.
PMID: Cell Stress Chaperones. 2020 Jan 2. Epub 2020 Jan 2. PMID: 31898286 Abstract Title: α-Mangostin reduced the viability of A594 cells in vitro by provoking ROS production through downregulation of NAMPT/NAD. Abstract: α-Mangostin (MAN) is a bioactive compound isolated from the inedible pericarp of a tropical fruit mangosteen (Garcinia mangostana Linn). It exhibits notable …
Novel use of N-acetylcysteine in management of tyrosine kinase inhibitor induced acute liver injury.
PMID: Cureus. 2019 Nov 27 ;11(11):e6251. Epub 2019 Nov 27. PMID: 31890447 Abstract Title: Novel Use of N-Acetylcysteine in Management of Tyrosine Kinase Inhibitor Induced Acute Liver Injury. Abstract: Tyrosine kinase inhibitors (TKIs) have been adopted in the treatment of a variety of malignancies. Despite their popularity, the underlying mechanism of the adverse effects seen …
Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity.
PMID: Zhongguo Yao Li Xue Bao. 1992 May ;13(3):209-12. PMID: 1442100 Abstract Title: Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity. Abstract: Fulvotomentosides (Ful) is the total saponins of Lonicera fulvotomentosa. In the present study, we examined the effect of Ful on acetaminophen (AA)-induced hepatotoxicity in mice. Ful pretreatment (75-225 mg.kg-1, sc x 3 d) significantly …
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Constituents of L. fulvotomentosa and L. macranthoide are effective in decreasing carbon tetrachloride and D-Galactosamine-induced liver injuries.
PMID: Zhongguo Zhong Yao Za Zhi. 1999 Jun ;24(6):363-4, 384. PMID: 12212032 Abstract Title: [Hepatoprotective effect of several constituents of Lonicera fulvotomentosa hsu et S. C. cheng, and L. macranthoide Hand.-Mazz. on CC1(4) and D-galactosamine induced liver injuries in mice and rats]. Abstract: OBJECTIVE: To study the hepatoprotective effect of several constituents of Lonicera fulvotomentosa …
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