PMID: Oncol Lett. 2019 Sep ;18(3):3081-3091. Epub 2019 Jul 24. PMID: 31452785 Abstract Title: Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells. Abstract: Cancer stem cells (CSCs) have been implicated in the genesis, progression and recurrence of renal cancer. The sonic hedgehog (Shh) pathway serves a critical role in maintaining the stemness …
Continue reading “Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells”
PMID: Obstet Gynecol Sci. 2019 Sep ;62(5):322-328. Epub 2019 Aug 6. PMID: 31538075 Abstract Title: Effects of genistein on anti-tumor activity of cisplatin in human cervical cancer cell lines. Abstract: Objective: To investigate the effect of genistein on the anticancer effects of chemotherapeutic agents, we examined the effect of a genistein and cisplatin combination on …
PMID: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019 Aug 28 ;44(8):850-856. PMID: 31570670 Abstract Title: [Effects of genistein on Nrf2/HO-1 pathway in myocardial tissues of diabetic rats]. Abstract: To investigate the effects of genistein (Gen) on nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway in myocardial tissues of diabetic rats. …
Continue reading “Genistein exerted antioxidant effects on myocardial injury in diabetic rats.”
PMID: Gen Physiol Biophys. 2019 Sep ;38(5):389-397. PMID: 31595881 Abstract Title: A preliminary report: genistein attenuates cerebral ischemia injury in ovariectomized rats via regulation of the PI3K-Akt-mTOR pathway. Abstract: Stroke is a leading cause of disability and death in the worldwide. Therefore, prevention of stroke is critically important. Genistein, a natural phytoestrogen extracted from soybeans, …
Continue reading “Genistein attenuates cerebral ischemia injury in ovariectomized rats.”
PMID: Exp Ther Med. 2019 Nov ;18(5):3793-3800. Epub 2019 Sep 19. PMID: 31611933 Abstract Title: Inhibitory effects of genistein in combination with gefitinib on the hepatocellular carcinoma Hep3B cell line. Abstract: Combination therapy is an important method for treating advanced hepatocellular carcinoma (HCC). Gefitinib is an epidermal growth factor receptor (EGFR) inhibitor, which has profound …
PMID: Front Cell Dev Biol. 2019 ;7:197. Epub 2019 Sep 20. PMID: 31620438 Abstract Title: Emerging Signal Regulating Potential of Genistein Against Alzheimer's Disease: A Promising Molecule of Interest. Abstract: Alzheimer's disease (AD) is a progressive, irreversible brain disorder characterized by pathological aggregation of the amyloid-β peptide (Aβ) and tau protein; both of these are …
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PMID: Shock. 2019 Oct 15. Epub 2019 Oct 15. PMID: 31626039 Abstract Title: Genistein Protects Against Burn-Induced Myocardial Injury via Notch1 Mediated Suppression of Oxidative/Nitrative Stress. Abstract: Genistein (Gen) exhibits strong anti-oxidative/anti-nitrative activity and cardioprotective effects in several models; however, its role in burn-induced myocardial injury is unknown. This study investigated the protective effect of …
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PMID: J Environ Pathol Toxicol Oncol. 2019 ;38(2):143-152. PMID: 31679277 Abstract Title: Nrf2/HO-1 Mediated Protective Activity of Genistein Against Doxorubicin-Induced Cardiac Toxicity. Abstract: The current study evaluated the cardioprotective activity of genistein in cases of doxorubicin-(Dox) induced cardiac toxicity and a probable mechanism underlying this protection, such as an antioxidant pathway in cardiac tissues. Animals …
PMID: Diabetes Metab Syndr Obes. 2019 ;12:2011-2021. Epub 2019 Oct 3. PMID: 31686880 Abstract Title: Genistein diet improves body weight, serum glucose and triglyceride levels in both male and female ob/ob mice. Abstract: Purpose: Diabetic obesity in the leptin-deficient ob/ob mouse is associated with weight gain, and hyperglycemia, along with hyperinsulinemia. We have previously examined …
Continue reading “Genistein diet improves body weight, serum glucose and triglyceride levels.”
PMID: Curr Dev Nutr. 2019 Nov ;3(11):nzz121. Epub 2019 Oct 23. PMID: 31750414 Abstract Title: Bone Strength Is Improved with Genistein Treatment in Mice with Diet-Induced Obesity. Abstract: Background: High caloric intake of saturated fat and refined sugars accelerates the development of obesity and diabetes and increases bone fracture risk. Some evidence suggests that consumption …
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