PMID: Front Neurosci. 2019 ;13:1284. Epub 2019 Nov 28. PMID: 31849592 Abstract Title: Folic Acid and Risk of Preterm Birth: A Meta-Analysis. Abstract: The results from epidemiologic studies linking blood folate concentrations, folic acid supplementation, or dietary folate to the risk of preterm birth are inconsistent. In this study, we aimed to summarize the available …
Author Archives: Taylor Mercado
Folic acid supplementation reduces multigenerational sperm miRNA perturbation induced by in utero environmental contaminant exposure
PMID: Environ Epigenet. 2019 Oct ;5(4):dvz024. Epub 2019 Dec 14. PMID: 31853372 Abstract Title: Folic acid supplementation reduces multigenerational sperm miRNA perturbation induced byenvironmental contaminant exposure. Abstract: Persistent organic pollutants (POPs) can induce epigenetic changes in the paternal germline. Here, we report that folic acid (FA) supplementation mitigates sperm miRNA profiles transgenerationally followingpaternal exposure to …
Folic acid decreases astrocyte apoptosis by preventing oxidative stress-induced telomere attrition.
PMID: Int J Mol Sci. 2019 Dec 20 ;21(1). Epub 2019 Dec 20. PMID: 31861819 Abstract Title: Folic Acid Decreases Astrocyte Apoptosis by Preventing Oxidative Stress-Induced Telomere Attrition. Abstract: Astrocytes are the most widely distributed cells in the brain, and astrocyte apoptosis may play an important role in the pathogenesis of neurodegenerative diseases. Folate is …
Folic acid receptor-targeted solid lipid nanoparticles to enhance cytotoxicity of letrozole.
PMID: Pharm Dev Technol. 2020 Jan 2:1-11. Epub 2020 Jan 2. PMID: 31893979 Abstract Title: Folic acid receptor-targeted solid lipid nanoparticles to enhance cytotoxicity of letrozole through induction of caspase-3 dependent-apoptosis for breast cancer treatment. Abstract: Chemotherapy using cytotoxic agents, such as letrozole (LTZ), is one of the most effective treatments for hormone-dependent breast cancer. …
Panax notoginseng saponins suppress lipopolysaccharide-induced barrier disruption.
PMID: Phytother Res. 2019 Dec ;33(12):3163-3176. Epub 2019 Aug 30. PMID: 31468630 Abstract Title: Panax notoginseng saponins suppress lipopolysaccharide-induced barrier disruption and monocyte adhesion on bEnd.3 cells via the opposite modulation of Nrf2 antioxidant and NF-κB inflammatory pathways. Abstract: Dysfunction of the blood-brain barrier (BBB) is a prerequisite for the pathogenesis of many cerebral diseases. …
Panax Notoginseng saponins protect cardiac myocytes against endoplasmic reticulum stress and associated apoptosis.
PMID: Front Pharmacol. 2019 ;10:1013. Epub 2019 Sep 20. PMID: 31616293 Abstract Title: Protect Cardiac Myocytes Against Endoplasmic Reticulum Stress and Associated Apoptosis Through Mediation of Intracellular Calcium Homeostasis. Abstract: Endoplasmic reticulum (ER) stress has been demonstrated to play important roles in the pathogenesis of various cardiovascular diseases. The ER stress pathway is therefore a …
Panax notoginseng saponins ameliorate cisplatin-induced mitochondrial injury via the HIF-1α/mitochondria/ROS pathway.
PMID: FEBS Open Bio. 2019 Nov 12. Epub 2019 Nov 12. PMID: 31715069 Abstract Title: Panax notoginseng saponins ameliorate cisplatin-induced mitochondrial injury via the HIF-1α/mitochondria/ROS pathway. Abstract: Cisplatin is a major antineoplastic drug that is used to treat solid tumors, but its use is restricted by its nephrotoxicity. Such cisplatin-induced nephrotoxicity (CIN) is believed to …
Panax ginseng improves glucose metabolism in streptozotocin-induced diabetes.
PMID: Saudi J Biol Sci. 2019 Nov ;26(7):1436-1441. Epub 2018 Jun 5. PMID: 31762606 Abstract Title: Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5' adenosine monophosphate kinase up-regulation. Abstract: 5' AMP-activated protein kinase (AMPK), insulin receptors and transporters are distorted in diabetes mellitus. In this study, the effect ofwas assessed on glucose …
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Enhanced neuroprotective effects of Panax ginseng G115 and Ginkgo biloba GK501 combinations in vitro models of excitotoxicity.
PMID: Int J Mol Sci. 2019 Nov 22 ;20(23). Epub 2019 Nov 22. PMID: 31771121 Abstract Title: Enhanced Neuroprotective Effects ofG115andGK501Combinations In Vitro Models of Excitotoxicity. Abstract: Neurological-related disorders are seen as an increasingly important aspect of welfare. While conventional medicine is still the mainstay for the treatment of these diseases, it is becoming apparent …
Antimicrobial activities of Asian ginseng, American ginseng, and notoginseng.
PMID: Phytother Res. 2019 Dec 29. Epub 2019 Dec 29. PMID: 31885119 Abstract Title: Antimicrobial activities of Asian ginseng, American ginseng, and notoginseng. Abstract: Asian ginseng (Panax ginseng C.A. Meyer), American ginseng (Panax quinquefolius) and notoginseng (Panax notoginseng) are the three most commonly used ginseng botanicals in the world. With the increasing interests on antimicrobial …
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