PMID: 

Antioxidants (Basel). 2019 Oct 23 ;8(11). Epub 2019 Oct 23. PMID: 31652765

Abstract Title: 

Systematic Physical Exercise andSupplementation Improve Body Composition, Cardiorespiratory Fitness, and Blood Lipid Profile: Correlations of a Randomized Double-Blind Controlled Trial.

Abstract: 

Cardiovascular diseases are part of the highly preventable chronic diseases associated with changes in lifestyle. Within them, physical activity, low-fat and high-fiber diets are distinguished as the main support for prevention, even when supplementation with nutraceuticals has become a very common practice. Fifty-two young sedentary men with excess body weight (body mass index (BMI)≥ 25 kg·m) were enrolled in a randomized-crossover controlled trial [six weeks of a systematic physical exercise withor placebo supplementation (4.5 g·day)]. Body composition, blood lipid profile, and maximal oxygen uptake were determined pre/post intervention. Pairwise comparisons showed a significant improvement (

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PMID: 

Oxid Med Cell Longev. 2019 ;2019:3520789. Epub 2019 Jun 4. PMID: 31281573

Abstract Title: 

Improves the Regenerative Capacity of Young and Senescent Myoblasts and Promotes Muscle Regeneration.

Abstract: 

Sarcopenia is characterized by the loss of muscle mass, strength, and function with ageing. With increasing life expectancy, greater attention has been given to counteracting the effects of sarcopenia on the growing elderly population., a microscopic, unicellular, green alga with the potential for various pharmaceutical uses, has been widely studied in this context. This study is aimed at determining the effects ofon promoting muscle regeneration by evaluating myoblast regenerative capacity. Human skeletal myoblast cells were cultured and underwent serial passaging into young and senescent phases and were then treated with, followed by the induction of differentiation. The ability ofto promote myoblast differentiation was analysed through cellular morphology, real-time monitoring, cell proliferation, senescence-associated-galactosidase (SA–gal) expression, myogenic differentiation, myogenin expression, and cell cycle profiling. The results obtained showed that senescent myoblasts exhibited an enlarged and flattened morphology, with increased SA–gal expression, reduced myogenic differentiation, decreased expression of myogenin, and an increased percentage of cells in the/phase. Treatment withresulted in decreased SA–gal expression and promotion of myogenic differentiation, as observed via an increased fusion index, maturation index, myotube size, and surface area and an increased percentage of cells that stained positive for myogenin. In conclusion,improves the regenerative capacity of young and senescent myoblasts and promotes myoblast differentiation, indicating its potential to promote muscle regeneration.

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PMID: 

Mar Drugs. 2019 Oct 16 ;17(10). Epub 2019 Oct 16. PMID: 31623220

Abstract Title: 

Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from.

Abstract: 

Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as"inflamm-aging."In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) fromwere investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and D-galactose (D-gal)-induced aging in a murine model. Results indicated that PPC inhibits the production of the inflammatory cytokines TNF-α and IL-6, and the inflammatory mediator nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. It also protected mice from D-gal induced informatory aging by increasing the activity of the antioxidant enzyme, such as superoxide dismutase (SOD), inhibiting D-gal-induced NF-κB upregulation, and increasing PPARs expression in the brain and gut. The findings indicated that PPC has favorable anti-inflammatory and anti-aging properties, and could be useful in the treatment of acute inflammation and senescence diseases.

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PMID: 

Clin Nutr ESPEN. 2019 Apr ;30:199-203. Epub 2019 Feb 12. PMID: 30904222

Abstract Title: 

Association of vitamin B12 mediated hyperhomocysteinemia with depression and anxiety disorder: A cross-sectional study among Bhil indigenous population of India.

Abstract: 

BACKGROUND: Indigenous populations in India are amongst the poorest and most marginalized population groups experiencing severe health deprivation.AIM: The present study is the first study that aims to understand the association of micronutrient deficiencies (vitamin B12 and folate) and MTHFR C677T gene polymorphism with depression and generalized anxiety disorder (GAD) among the Bhil indigenous population of India.METHODS: A total of 303 participants aged 25-65 years of both sexes and unrelated up to first cousins belonging to Bhil indigenous population were recruited for the present study. Depression and generalized anxiety disorder were assessed using Patient Health Questionnaire and Generalized Anxiety Disorder scale, respectively. Biochemical analysis, DNA extraction and MTHFR C677T gene polymorphism analysis were done using standard protocols.RESULTS: Although, vitamin B12 and folate status was not found to be directly associated with depression and GAD, but hyperhomocysteinemia was posing more than three folds and six folds significant increased risk for depression and GAD, respectively. Further, it seems hyperhomocysteinemia was mediated by vitamin B12 deficiency among depressed and anxious individuals. T allele of MTHFR C677T gene polymorphism was posing increased risk for depression and anxiety disorder though not significant.CONCLUSION: The present study highlights the significance of micronutrient deficiencies in the causation of depression and anxiety disorder.

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PMID: 

J Clin Endocrinol Metab. 2019 Oct 1 ;104(10):4837-4847. PMID: 30920623

Abstract Title: 

Hyperglycemia and Metformin Use Are Associated With B Vitamin Deficiency and Cognitive Dysfunction in Older Adults.

Abstract: 

CONTEXT: Emerging evidence suggests that deficiencies of folate-related B vitamins can arise with metformin treatment and are independently linked with cognitive dysfunction, a comorbidity of diabetes.OBJECTIVE: To determine the impact of hyperglycemia and metformin use on relevant B vitamin biomarkers and cognitive outcomes in older adults.SETTING AND PARTICIPANTS: Community-dwelling older adults (74.1± 8.3 years, n = 4160) without dementia, recruited to the Trinity, Ulster and Department of Agriculture cohort study in 2008 to 2012, were classified as normoglycemic (n = 1856) or hyperglycemic, based on HbA1c ≥5.7% (39 mmol/mol), either with (n = 318) or without (n = 1986) metformin treatment.MAIN OUTCOME MEASURES: Biomarkers of folate, vitamin B12, vitamin B6, and riboflavin were measured. Cognitive assessments included the Repeatable Battery for Assessment of Neuropsychological Status (RBANS) and the Frontal Assessment Battery (FAB).RESULTS: Metformin use was associated with higher risk of deficiency of vitamin B12 (combined B12 index≤-1; OR 1.45; 95% CI, 1.03 to 2.02) and vitamin B6 (plasma pyridoxal 5-phosphate

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PMID: 

Br J Nutr. 2019 Jun ;121(11):1303-1312. Epub 2019 Apr 2. PMID: 30935438

Abstract Title: 

Maternal plasma vitamin B12 concentrations during pregnancy and infant cognitive outcomes at 2 years of age.

Abstract: 

Evidence on long-term influences of maternal vitamin B12 deficiency or concentrations on infant cognition is limited. We examined associations between maternal plasma vitamin B12 and cognitive development in 24-month-old infants. Maternal plasma vitamin B12 concentrations were measured at 26-28 weeks' gestation; infant cognitive development was assessed with the Bayley Scales of Infant and Toddler Development-III at 24 months, for 443 mother-infant pairs from the Growing Up in Singapore Towards Healthy Outcomes cohort. Linear regressions adjusted for key confounders examined associations of maternal vitamin B12 with cognitive, receptive and expressive language, fine and gross motor subscales. Co-occurrence of maternal vitamin B12 with folate or vitamin B6 insufficiencies on child's cognition was explored. Average maternal plasma vitamin B12 concentrations was 220·5 ± 80·5 pmol/l; 15 % and 41 % of mothers were vitamin B12 deficient (<148 pmol/l) and insufficient (148-220·9 pmol/l), respectively. Infants of mothers with vitamin B12 deficiency had 0·42 (95 % CI -0·70, -0·14) sd lower cognitive scores, compared with infants of mothers with sufficient vitamin B12. Co-occurrence of maternal vitamins B12 and B6 insufficiencies was associated with 0·37 (95 % CI -0·69, -0·06) sd lower cognitive scores in infants compared with infants of mothers sufficient in both vitamins. No significant associations were observed with other subscales. Study findings suggest the possible need to ensure adequate vitamin B12 during pregnancy. The impact of co-occurrence of maternal B-vitamins insufficiencies on early cognitive development warrants further investigation.

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PMID: 

BMJ Case Rep. 2019 May 14 ;12(5). Epub 2019 May 14. PMID: 31092496

Abstract Title: 

Reversible dementia, psychotic symptoms and epilepsy in a patient with vitamin Bdeficiency.

Abstract: 

Vitamin Bdeficiency is a common condition, typically associated with megaloblastic anaemia, glossitis and neuropsychiatric symptoms. We report the case of a patient presenting with progressive cognitive and functional deterioration, psychosis and seizures, later found to be secondary to pernicious anaemia. Importantly, the diagnosis of pernicious anaemia was only established 5 years after symptom onset and was overlooked even when the patient was under medical care, in part due to the lack of classic neurological and haematological signs associated with the condition. The patient had a remarkable neuropsychiatric recovery after vitamin replacement and psychopharmacological management. We discuss similar presentations of vitamin Bdeficiency found in the literature, symptom reversibility and the importance of its early recognition and treatment.

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PMID: 

Indian J Endocrinol Metab. 2019 Mar-Apr;23(2):211-214. PMID: 31161105

Abstract Title: 

Vitamin B12 Deficiency is Endemic in Indian Population: A Perspective from North India.

Abstract: 

Background: Vitamin B12 deficiency is believed to be widespread in Indian population. However, more data is needed to fuel a meaningful debate on preventive and therapeutic strategies.Aims and Objectives: Objective of the current study is to evaluate status of vitamin B12 levels in people from a tier 3 city and among people living in an urban area with or without diabetes.Settings and Design: Retrospective, cross-sectional study.Methodology: Data captured in electronic medical records (EMR) of an endocrine practice and from a diagnostic laboratory was analysed.Statistical Analysis Used: Statistical analysis was done using open source software"Jamovi".Results: Prevalence of vitamin B12 deficiency (Vitamin B12 levels

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PMID: 

SAGE Open Med. 2019 ;7:2050312119853433. Epub 2019 May 23. PMID: 31205703

Abstract Title: 

Prevalence of vitamin Bdeficiency among metformin-treated type 2 diabetic patients in a tertiary institution, South-South Nigeria.

Abstract: 

Background: The risk of chronic metformin pharmacotherapy to cause vitamin Bdeficiency and its associated medical complications has been of immense concern among diabetic patients. Some studies have postulated that vitamin Bdeficiency is highly prevalent among chronic metformin-treated adult diabetic patients.Aim: This study aimed to determine the prevalence of vitamin Bdeficiency among metformin-treated and metformin-naïve type 2 diabetes mellitus patients.Materials and methods: This was a case-control, prospective, analytical, observational study of 200 adult participants (100 per group) attending the Endocrinology, Medical Out-patients Clinic of Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria. The participants' serum vitamin Blevels were determined using an immunoassay technique. Data were presented using tables and charts. Chi-square test was used to compare non-continuous proportional variables.Results: The prevalence of vitamin Bdeficiency was 41% and 20% among metformin-treated and metformin-naïve type 2 diabetes mellitus groups, respectively (p = 0.001). Borderline vitamin Bstatus was present among 59% of metformin-treated group and 80% of metformin-naïve group (p = 0.001). Neither metformin-treated nor metformin-naïve groups had normal serum vitamin Blevels.Conclusion: The prevalence of vitamin Bdeficiency was significantly high in diabetics, especially the metformin-treated patients. We advocate for vitamin Bsupplementation among this group of patients in order to prevent the occurrence of vitamin Bdeficiency complications such as macro-ovalocytic anemia, impaired immunity with hypersegmented neutrophils, peripheral neuropathy and subacute degeneration of the spinal cord.

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PMID: 

Front Endocrinol (Lausanne). 2019 ;10:414. Epub 2019 Jun 27. PMID: 31316466

Abstract Title: 

Inverse Association Between Serum Vitamin B12 Concentration and Obesity Among Adults in the United States.

Abstract: 

Several studies have suggested that vitamin B12 deficiency is more common in obese individuals. We evaluated the cross-sectional associations of serum vitamin B12 concentrations with obesity in a nationally representative sample of adults in the United States.We included 9,075 participants aged≥20 years in the National Health and Nutrition Examination Survey 2011-2014. Serum vitamin B12 concentrations were measured by electrochemiluminescence immunoassay. Obesity was defined as BMI ≥30 kg/m. We used logistic regression with sample weights to estimate the odds ratios (ORs) and 95% confidence intervals (CIs).Serum vitamin B12 concentrations were lower among obese adults compared with non-obese adults. After adjustment for age, gender, race/ethnicity, socioeconomic status, dietary and lifestyle factors, use of medications that could affect the serum vitamin B12 levels, dietary supplement use and fasting time, the multivariable-adjusted ORs (95% CIs) of obesity were 1.00 (reference), 0.95 (0.79, 1.14), 0.86 (0.74, 0.99), and 0.71 (0.60, 0.84) (for trend

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