PMID: 

Electromagn Biol Med. 2013 Sep ;32(3):363-72. Epub 2013 Jan 16. PMID: 23324065

Abstract Title: 

Do 100- and 500-μT ELF magnetic fields alter beta-amyloid protein, protein carbonyl and malondialdehyde in rat brains?

Abstract: 

Several studies still state that presently accepted safety standards for extremely low-frequency magnetic fields (ELF-MFs) do not provide adequate protection, and therefore the standards are still open to question. To help resolve this question, the aim of this study was to illuminate the interaction between biomolecules and ELF-MFs by investigating the effect of ELF-MFs on beta-amyloid protein (BAP), protein carbonyl (PC) and malondialdehyde (MDA) in rat brain. For this study, 30 adult male Sprague-Dawley rats were used, which were divided into two experimental groups and a sham exposed group. Rats in two experimental groups were exposed to 100- and 500-μT ELF-MFs (50 Hz) for 2 h/day for 10 months, which are the generally accepted safety standards for public and occupational exposures. The same procedures were applied to the rats in the sham group, but with the generator turned off. The results of this study showed that neither ELF-MFs used in this study altered BAP level significantly (p>0.05). However, PC and MDA levels were increased by the exposure to 100- and 500-μT ELF-MFs (p 

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PMID: 

Biol Trace Elem Res. 2010 Dec ;138(1-3):238-49. Epub 2010 Feb 23. PMID: 20177816

Abstract Title: 

Effects of extremely low-frequency magnetic field on caspase activities and oxidative stress values in rat brain.

Abstract: 

This study was aimed to investigate the effect of extremely low-frequency magnetic field (ELF-MF) on apoptosis and oxidative stress values in the brain of rat. Rats were exposed to 100 and 500µT ELF-MF, which are the safety standards of public and occupational exposure for 2 h/day for 10 months. Brain tissues were immunohistochemically stained for the active (cleaved) caspase-3 in order to measure the apoptotic index by a semi-quantitative scoring system. In addition, the levels of catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidative capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were measured in rat brain. Final score of apoptosis and MPO activity were not significantly different between the groups. CAT activity decreasedin both exposure groups (p

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PMID: 

Electromagn Biol Med. 2007 ;26(2):99-106. PMID: 17613037

Abstract Title: 

Alteration of nitric oxide production in rats exposed to a prolonged, extremely low-frequency magnetic field.

Abstract: 

The purpose of this study is to investigate the possible effect of an extremely low-frequency magnetic field (ELF-MF) on nitric oxide (NO) level. In this study, 27 male Sprague-Dawley rats were used. The rats were divided into three groups: two experimental and one control (sham-exposed). The first and second experimental group (n = 10) were exposed to 100 microT and 500 microT ELF-MF during 10 months, 2 h a day, respectively, and the third (n = 7) group was treated like an experimental group except for ELF-MF exposure in methacrylate boxes. After ELF-MF and sham exposure, serum nitrite levels were measured by Griess reaction. A significant reduction was observed in nitrite levels among the first and second experimental groups of rats and sham-exposed rats after exposure for 10 months, 2 h a day, to ELF-MF of 100 and 500 microT (p

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PMID: 

Int J Vitam Nutr Res. 2018 Dec ;88(5-6):234-243. Epub 2019 May 24. PMID: 31124742

Abstract Title: 

Instant White Rice with Pigmented Giant Embryonic Rice Improves Glucose Metabolism and Inhibits Oxidative Stress in High-Fat Diet-Fed Mice.

Abstract: 

The effects of instant cooked rice made from a combination of white rice and pigmented giant embryonic Keunnunjami rice, in comparison with those of instant regular white or brown rice and instant non-pigmented giant embryonic brown rice, on the glucose metabolism and antioxidant defense status in high-fat diet-fed mice were investigated. 56 male C57BL/6N mice were randomly divided into 7 dietary groups: normal control, high fat (23 %, HF), and HF supplemented with normal white (HF + NW) or brown rice (HF + NB), non-pigmented giant embryonic rice (HF + GB), and white rice with 8 % Keunnunjami (HF + KJ8) and 18 % Keunnunjami (HF + KJ18). After 7 weeks, HF mice showed marked increases in blood glucose (156 mg/dL), plasma insulin (12.1 mg/mL), and lipid peroxidation, and a significant decrease in hepatic glycogen (14.2 mg/g) relative to the control group (

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PMID: 

J Agric Food Chem. 2019 Oct 9. Epub 2019 Oct 9. PMID: 31549821

Abstract Title: 

Whole Grain Brown Rice Extrudate Ameliorates the Symptoms of Diabetes by Activating the IRS1/PI3K/AKT Insulin Pathway in db/db Mice.

Abstract: 

The therapeutic benefits of whole grains on diabetes mellitus have been continuously confirmed by in-depth research. To date, limited studies have investigated the effect of extruded products of whole grains on the insulin signaling pathway in vivo. This study investigated the effects of oral consumption of whole grain extrudate, including 97% brown rice and 3% defatted rice bran (w/w, BRD), on glucose metabolism and the hepatic insulin signaling pathway in C57BL/KsJ-db/db mice. BRD treatment induced a remarkable reduction in blood glucose. Moreover, glucose intolerance and insulin resistance were ameliorated in the BRD-treated group compared with those in the db/db control group. BRD also increased the hepatic glycogen content by reducing the expression and increasing the phosphorylation of glycogen synthase kinase 3β (GSK3β). The activities of glucose-6-phosphatase and phosphoenolpyruvate carboxylase and their respective mRNA expression levels in the liver were simultaneously decreased in the BRD-treated group. BRD also significantly upregulated the expression of phosphatidylinositol 3-kinase (PI3K) and increased the phosphorylation of insulin receptor substrate 1 (IRS1) and protein kinase B (AKT). These results indicate that BRD exhibits antidiabetic potential by activating the IRS1/PI3K/AKT signaling pathway, further regulating the expression of thegene and p-GSK3β protein, thus inhibiting hepatic gluconeogenesis, increasing hepatic glycogen storage, and improving insulin resistance. Therefore, BRD could be used as a functional ingredient to alleviate the symptoms of hyperglycemia.

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PMID: 

Environ Res. 2018 05 ;163:165-170. Epub 2018 Feb 22. PMID: 29438901

Abstract Title: 

Role of radical pairs and feedback in weak radio frequency field effects on biological systems.

Abstract: 

Radio frequency electromagnetic fields (RF) have been shown to modify the concentrations of the radical O, HOand cancer cell growth rates at exposure levels below those that cause significant heating. Reactive oxygen species (ROS) are both signaling molecules and species that can do damage, depending on timing, location and concentrations. We briefly look at some mechanisms by which electromagnetic fields can modify the concentrations of ROS and some of the feedback and repair processes that lead to variable biological effects. Of particular interest are the role of radical pairs and their spins, which have received considerable attention recently, and the role of feedback in biological systems, to which less attention has been paid.

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PMID: 

Food Sci Nutr. 2019 Sep ;7(9):2888-2896. Epub 2019 Jul 30. PMID: 31572582

Abstract Title: 

Antihypertensive effect of giant embryo brown rice and pre-germinated giant embryo brown rice on spontaneously hypertensive rats.

Abstract: 

"Shangshida NO.5"is a giant embryo mutant resulting from giant embryo gene () dysfunction in"Chao2-10"rice. Here, we compared the antihypertensive effects of"Chao2-10"brown rice (C2-10),"Shangshida NO.5"brown rice (GER), and pre-germinated"Shangshida NO.5"brown rice (PGER) in spontaneously hypertensive rats (SHR). Male SHR at 6 weeks of age were divided into four groups and were fed with (a) a control diet (control), (b) a 40% C2-10-supplemented diet (C2-10), (c) a 40% GER-supplemented diet (GER), or (d) a 40% PGER-supplemented diet (PGER) for 8 weeks, and their physiological and biochemical parameters were measured. The results showed that the C2-10-, GER-, and PGER-supplemented diets significantly decreased systolic blood pressure (SBP) and diastolic blood pressure (DBP) during the experiment. At the end of the experimental period, the SBP and DBP of the C2-10, GER, and PGER groups were 7.6, 23.3, and 31.1 mmHgand 9.8, 21.1, and 29 mmHg lower than those in the control group, respectively, suggesting the GER and PGER diets were better able to inhibit blood pressure elevation than the C2-10 diet. The serum creatinine levels in the C2-10, GER, and PGER groups and the blood urea nitrogen content in the PGERgroup were significantly lower than those of the control group, indicating that C2-10-, GER-, and especially PGER-supplemented diets improved renal function. In addition, the antioxidant activity of the C2-10 group and especially of the GER and PGER groups also improved. The above results suggest that"Shangshida NO.5"rice, particularly pre-germinated rice, is a good dietary supplement for preventing the development of hypertension.

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PMID: 

Electromagn Biol Med. 2010 Aug ;29(3):122-30. PMID: 20707646

Abstract Title: 

Differentiation of K562 cells under ELF-EMF applied at different time courses.

Abstract: 

The time-course of ELF-EMF application to biological systems is thought to be an important parameter determining the physiological outcome. This study investigated the effect of ELF-EMF on the differentiation of K562 cells at different time courses. ELF-EMF (50 Hz, 5 mT, 1 h) was applied at two different time-courses; first at the onset of hemin induction for 1 h, and second, daily 1 h for four days. While single exposure to ELF-EMF resulted in a decrease in differentiation, ELF-EMF applied everyday for 1 h caused an increase in differentiation. The effect of co-stressors, magnesium, and heat-shock was also determined and similar results were obtained. ELF-EMF increased ROS levels in K562 cells not treated with hemin, however did not change ROS levels of hemin treated cells indicating that ROS was not the cause. Overall, these results imply that the time-course of application is an important parameter determining the physiological response of cells to ELF-EMF.

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PMID: 

J Nutr Sci Vitaminol (Tokyo). 2019 ;65(Supplement):S122-S124. PMID: 31619610

Abstract Title: 

Effect of Continuous Dewaxed Brown Rice Ingestion on the Cognitive Function of Elderly Individuals.

Abstract: 

Dewaxed brown rice (DBR), which is prepared by removing only the outermost wax layer of brown rice using a new rice milling technique, has improved water absorbency, digestibility, and taste compared to regular brown rice. DBR has a nutritional value close to that of brown rice, including a rich amount of lipopolysaccharides that are known to improve cognitive function in mice. This study thus aimed to verify the influence of continuous DBR ingestion on cognitive function among elderly individuals. The present study employed a crossover comparison design using the Revised Hasegawa Dementia Scale to assess cognitive function. Our findings confirmed that long-term DBR ingestion contributed to the prevention and reduction of overall cognitive decline, especially among elderly individuals with low cognitive function. Thus, DBR has the potential to be a useful staple food that maintains brain homeostasis among elderly individuals.

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PMID: 

J Nutr Sci Vitaminol (Tokyo). 2019 ;65(Supplement):S80-S87. PMID: 31619653

Abstract Title: 

Influence of Ultra-High Hydrostatic Pressurizing Brown Rice on Cognitive Functions and Mental Health of Elderly Japanese Individuals: A 2-Year Randomized and Controlled Trial.

Abstract: 

Brown rice contains many ingredients that might protect against cognitive decline and Alzheimer's disease. However, brown rice is very hard, difficult to cook, and is poorly digested; thus, it is difficult to eat long-term. To solve these problems, ultra-high hydrostatic pressurizing brown rice (UHHPBR) was prepared. We investigated the effects of dietary UHHPBR administration for 24 mo on cognitive function and mental health in the elderly. Healthy elderly participants (n=52) were randomized into UHHPBR and polished white rice (WR) groups. The UHHPBR group consumed 100 g of UHHPBR per day for 24 mo and the WR group consumed white rice. At baseline, and after 12 and 24 mo, cognitive functions were assessed using the Revised Hasegawa's Dementia Scale, Mini-Mental State Examination, Frontal Assessment Battery (FAB), and the Cognitive Assessment for Dementia, iPad version (CADi). Mental health condition was also assessed using the Apathy Scale and the Zung Self-Rating Depression Scale, and serum biochemical parameters were determined. From baseline to month 24, the mean change in the FAB-sub item 1 scores was higher in the UHHPBR group compared to the WR group. Furthermore, apathy scores decreased, as well as the time required to answer all questions of the CADi, and plasma epinephrine levels increased. These results indicate that a 2-y oral consumption of UHHPBR increases information processing speed (as a measure of cognitive function) and improves apathy in the elderly, suggesting a protective effect of UHHPBR administration against age-related decline in brain cognition and motivation.

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