PMID: 

Arch Physiol Biochem. 2019 Sep 23:1-5. Epub 2019 Sep 23. PMID: 31545080

Abstract Title: 

Evaluating the effects ofL. extract on hyperglycaemia and insulin sensitivity in experimental type 2 diabetes in rat.

Abstract: 

The present study aimed to investigate the effects of(JR) extract on hyperglycaemia and insulin sensitivity.Forty rats were divided into 4 groups: Control (C), Diabetes Control (DC), Diabetes +(D + JR) and Diabetes + Metformin (D + M).In the D + JR group, Fasting blood glucose (FBG) levels decreased from day 14 onwards. There was a significant decrease in plasma levels of Fibronectin Type III Domain Containing 5 (FNDC5) and adiponectin (ADP) in the DC group compared to the C group ( 

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PMID: 

Radiats Biol Radioecol. 2008 Jan-Feb;48(1):92-101. PMID: 18666585

Abstract Title: 

[The change of negative components of the evoked potentials of spinal cord after irradiating of a SHF-waves].

Abstract: 

The influence of super high frequency (SHF) waves (lambda = 3 sm) nonthermal intensity (1.6 mWt/sm2) on work of regulator systems of a spinal cord (SC) of cats was considered. The estimation of parameters of negative components of cord dorsum potential (CDP) is made for stimulus, which apply on peripheral nerves or dorsal root earlier and after the influence of SHF on SC. Change in work of population of segmentary and non-segmentary interneurons after the SHF irradiation with 30 minutes exposition was shown. The authors consider that the main influence SHF waves is directed on a changes of membrane potential of SC neurons. The specified effect carries temporary and convertible character.

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PMID: 

Electromagn Biol Med. 2009 ;28(2):215-22. PMID: 19811403]

Abstract Title: 

Blood-brain barrier disruption by continuous-wave radio frequency radiation.

Abstract: 

The increasing use of cellular phones and the increasing number of associated base stations are becoming a widespread source of non ionizing electromagnetic radiation. Some biological effects are likely to occur even at low-level EM fields. This study was designed to investigate the effects of 900 and 1,800 MHz Continuous Wave Radio Frequency Radiation (CW RFR) on the permeability of Blood Brain Barrier (BBB) of rats. Results have shown that 20 min RFR exposure of 900 and 1,800 MHz induces an effect and increases the permeability of BBB of male rats. There was no change in female rats. The scientific evidence on RFR safety or harm remains inconclusive. More studies are needed to demonstrate the effects of RFR on the permeability of BBB and the mechanisms of that breakdown.

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PMID: 

Int J Biol Sci. 2019 ;15(11):2497-2508. Epub 2019 Sep 7. PMID: 31595166

Abstract Title: 

Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis.

Abstract: 

Deregulation of glycolysis is a common phenomenon in human colorectal cancer (CRC). In the present study, we reported that Hexokinase 2 (HK2) is overexpressed in human CRC tissues and cell lines, knockout of HK2 inhibited cell proliferation, colony formation, and xenograft tumor growth. We demonstrated that the natural compound, xanthohumol, has a profound anti-tumor effect on CRC via down-regulation of HK2 and glycolysis. Xanthohumol suppressed CRC cell growth bothand. Treatment with xanthohumol promoted the release of cytochrome C and activated the intrinsic apoptosis pathway. Moreover, our results revealed that xanthohumol down-regulated the EGFR-Akt signaling, exogenous overexpression of constitutively activated Akt1 significantly impaired xanthohumol-induced glycolysis suppression and apoptosis induction. Our results suggest that targeting HK2 appears to be a new approach for clinical CRC prevention or treatment.

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PMID: 

Anesthesiology. 2005 Jan ;102(1):125-31. PMID: 15618796

Abstract Title: 

Pulsed and continuous radiofrequency current adjacent to the cervical dorsal root ganglion of the rat induces late cellular activity in the dorsal horn.

Abstract: 

BACKGROUND: Pulsed radiofrequency treatment has recently been described as a non-neurodestructive or minimally neurodestructive alternative to radiofrequency heat lesions. In clinical practice long-lasting results of pulsed radiofrequency treatment adjacent to the cervical dorsal root ganglion for the management of chronic radicular spinal pain have been reported without neurologic complications. However, the mode of action is unclear. An early (3 h) effect of pulsed radiofrequency as measured by an increase of c-Fos in the pain-processing neurons of the dorsal horn of rats has been described in the literature. This effect was not mediated by tissue heating. The authors investigated a possible late or long-term effect of three different radiofrequency modalities.METHODS: Cervical laminectomy was performed in 19 male Wistar rats. The cervical dorsal root ganglion was randomly exposed to one of the four interventions: sham, continuous radiofrequency current at 67 centigrades, or pulsed radiofrequency current for 120 s or 8 min. The animals were sacrificed and the spinal cord was prepared for c-Fos labeling 7 days after the intervention.RESULTS: The number of c-Fos immunoreactive cells in the dorsal horn was significantly increased in the three different radiofrequency modalities as compared with sham. No significant difference was demonstrated between the three active intervention groups.CONCLUSIONS: The authors demonstrated a late neuronal activity in the dorsal horn after exposure of the cervical dorsal root ganglion to different radiofrequency modalities, which was not temperature dependent.

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PMID: 

Int J Radiat Biol. 2004 Sep ;80(9):691-8. PMID: 15586889

Abstract Title: 

Repeated exposure to low-level extremely low frequency-modulated microwaves affects baseline and scopolamine-modified electroencephalograms in freely moving rats.

Abstract: 

PURPOSE: To compare in the electroencephalogram of rats the effects of scopolamine (an acetylcholine receptor antagonist) alone and after repeated exposure to low-level microwaves modulated at extremely low frequency.MATERIALS AND METHODS: Averaged frequency spectra (0.5-30 Hz) of the electroencephalogram were studied in freely moving rats with carbon electrodes implanted into the somatosensory cortex. The rats were repeatedly (3 days, 30 min day(-1)) exposed to low-intensity (approximately = 0.3 mW cm(-2)) microwaves (915 MHz, 20-ms pulse duration), amplitude modulated (square-wave) at extremely low frequency (4 Hz).RESULTS: The exposure to extremely low frequency microwaves alone significantly enhanced the fast electroencephalographic rhythms (18-30 Hz). This effect was observed neither in subsequent sham-exposure experiment nor in radiation-naïve animals. In the microwave-exposed rats, scopolamine (0.1 mg kg(-1), subcutaneously) did not cause a slowing in the electroencephalogram that was shown in non-exposed rats. A similarity between the scopolamine-induced electroencephalogram effect in the microwave-exposed rats and that of physostigmine (enhancing the acetylcholine level in the brain) in radiation-naïve animals was noted. This paradoxical phenomenon stimulates new experimentation for understanding its mechanism(s).CONCLUSIONS: The data obtained provide additional evidence that repeated low-level exposure to extremely low frequency microwaves can modify an activity of cholinergic system in the brain.

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PMID: 

Brain Res Bull. 2001 Jun ;55(3):367-74. PMID: 11489344

Abstract Title: 

Regional distribution of Hsp70 in the CNS of young and old food-restricted rats following hyperthermia.

Abstract: 

We examined the effect of aging on the capacity of the brain to produce heat shock protein (Hsp70) in response to heat stress, using high-powered microwaves (HPM, 2.06 GHz, 2.2 W/cm(2)) to induce hyperthermia for periods so brief that thermoregulatory factors were functionally eliminated as confounding variables. Unanesthetized young (6 months) and old (25 months) male, food-restricted Sprague-Dawley rats were exposed to HPM to induce a mean peak tympanic temperature (T(ty)) of 42.2 degrees C within 30 s. T(ty) returned to

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PMID: 

Int J Vitam Nutr Res. 2019 Sep 12:1-15. Epub 2019 Sep 12. PMID: 31512981

Abstract Title: 

Effect of pomegranate fruit supplementation on performance and various markers in athletes and active subjects: a systematic review.

Abstract: 

The aim of the study was to review recent findings on the use of POM supplements in athletes of various disciplines and physically active participants. Eleven articles published between 2010 and 2018 were included, where the total number of investigated subjects was 176. Male participants constituted the majority of the group (n = 155), as compared to females (n = 21). 45% of research described was conducted on athletes, whereas the remaining studies were based on highly active participants. Randomised, crossover, double-blind study designs constituted the majority of the experimental designs used. POM supplementationvaried in terms of form (pills/juice), dosage (50 ml-500 ml) and time of intervention (7 days-2 months) between studies. Among the reviewed articles, POM supplementation had an effect on the improvement of the following: whole body strength; feeling of vitality; acute and delayed muscle fatigue and soreness; increase in vessel diameter; blood flow and serum level of TAC; reduction in the rate of increase for HR, SBP, CK and LDH; support in the recovery of post-training CK, LDH, CRP and ASAT to their baseline levels; reduction of MMP2, MMP9, hsCRP and MDA; and increased activity of antioxidant enzymes (glutathione peroxidase and superoxide dismutase). In the majority of reviewed articles POM supplementation had a positive effect on a variety of parameters studied and the authors recommended it as a supplement for athletes and physically active bodies.

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PMID: 

Food Funct. 2019 Jul 17 ;10(7):3880-3889. PMID: 31187839

Abstract Title: 

Red yeast rice ameliorates high-fat diet-induced atherosclerosis in Apoemice in association with improved inflammation and altered gut microbiota composition.

Abstract: 

Gut microbiota plays an important role in many metabolic diseases and has been linked to cardiovascular disease, including atherosclerosis. Clinical studies suggest that red yeast rice (RYR) has the potential to reduce blood lipid levels. However, the mechanisms under which RYR regulates atherosclerosis by affecting the composition of the gut microbiome have not been elucidated. In the current study, results showed that treatment with RYR significantly decreased the plaque formation and levels of cholesterol and low-density lipoprotein (LDL) compared with the atherosclerotic model group which were fed with a high-fat diet. In addition, the height of enteral villus in the red Monascus group was increased, indicating that RYR can improve the intestinal barrier function. Further analysis revealed that RYR might attenuate atherosclerosis through inhibiting hydroxy methylglutaryl-CoA reductase and the consequent inflammatory signaling pathways mediated by TLR2 and TLR4. Moreover, the RYR treatment led to significant structural changes on the intestinal microbiota of high-fat diet-fed mice and reduced the relative abundance of Alistipes and Flavonifractor that exhibited positive relationships with the plasma levels of cholesterol and LDL. Collectively, these findings illustrated that RYR could significantly protect against atherosclerosis, which was possibly associated with the alterations in the gut microbiota composition.

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PMID: 

Pharmacol Res. 2019 May ;143:1-16. Epub 2019 Mar 4. PMID: 30844537

Abstract Title: 

Safety of red yeast rice supplementation: A systematic review and meta-analysis of randomized controlled trials.

Abstract: 

Recently, concerns regarding the safety of red yeast rice (RYR) have been raised after the publication of some case reports claiming toxicity. Since the previous meta-analyses on the effects of RYR were mainly focused on its efficacy to improve lipid profile and other cardiovascular parameters, we carried out a meta-analysis on safety data derived from the available randomized controlled clinical trials (RCTs). Primary outcomes were musculoskeletal disorders (MuD). Secondary outcomes were non-musculoskeletal adverse events (Non-MuD) and serious adverse events (SAE). Subgroups analyses were carried out considering the intervention (RYR alone or in association with other nutraceutical compounds), monacolin K administered daily dose (≤3, 3.1-5 or>5 mg/day), follow-up (>12 or≤12 weeks), with statin therapy or statin-intolerance and type of control treatment (placebo or statin treatment). Data were pooled from 53 RCTs comprising 112 treatment arms, which included 8535 subjects, with 4437 in the RYR arm and 4303 in the control one. Monacolin K administration was not associated with increased risk of MuD (odds ratio (OR) = 0.94, 95% confidence interval (CI) 0.53,1.65). Moreover, we showed reduced risk of Non-MuD (OR = 0.59, 95%CI 0.50, 0.69) and SAE (OR = 0.54, 95%CI 0.46, 0.64) vs. control. Subgroups analyses confirmed the high tolerability profile ofRYR. Furthermore, increasing daily doses of monacolin K were negatively associated with increasing risk of Non-MuD (slope: -0.10; 95%CI: -0.17, -0.03; two-tailed p 

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