PMID: Chem Biol Interact. 2019 Dec 21:108926. Epub 2019 Dec 21. PMID: 31874164 Abstract Title: GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway. Abstract: Grape seed proanthocyanidin extract (GSPE) has been reported to exhibit a variety of protective effects, such as antioxidant, anti-atherosclerosis and other pharmacological effects. As a member …
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Potential role of cannabidiol for seizure control in a patient with recurrent glioma.
PMID: J Clin Neurosci. 2019 Dec 14. Epub 2019 Dec 14. PMID: 31848037 Abstract Title: Potential role of cannabidiol for seizure control in a patient with recurrent glioma. Abstract: Glioma-related epilepsy significantly impact on patients' quality of life, and can often be difficult to treat. Seizures cause significant morbidity for example neurocognitive deterioration, which may …
CBD has a promising role as alternative therapy in the management of anxiety disorders.
PMID: J Am Pharm Assoc (2003). 2019 Dec 19. Epub 2019 Dec 19. PMID: 31866386 Abstract Title: Use of cannabidiol in anxiety and anxiety-related disorders. Abstract: OBJECTIVE: Cannabidiol (CBD) has a proposed novel role in the management of anxiety owing to its actions on the endocannabinoid system. The purpose of this systematic review was to …
Alpha-lipoic acid supplementation may be a useful strategy to improve insulin sensitivity in pre-diabetic subjects.
PMID: Food Funct. 2019 Sep 1 ;10(9):5732-5738. Epub 2019 Aug 27. PMID: 31453617 Abstract Title: Metabolic effects ofα-lipoic acid supplementation in pre-diabetics: a randomized, placebo-controlled pilot study. Abstract: Supplementation of health promoting nutraceuticals may be an effective adjunct strategy with other lifestyle and drug approaches to impede disease progression in prediabetic subjects.α-Lipoic acid, a naturally …
Alpha-lipoic acid improves endothelial dysfunction in high-fat diet-fed obese mice.
PMID: Biol Pharm Bull. 2019 ;42(9):1456-1463. PMID: 31474707 Abstract Title: Chronic Treatment withα-Lipoic Acid Improves Endothelium-Dependent Vasorelaxation of Aortas in High-Fat Diet-Fed Mice. Abstract: α-Lipoic acid (ALA) is used as a dietary supplement and known as an anti-oxidant. The present study aimed to examine whether ALA improves endothelial dysfunction in high-fat diet-fed obese mice. After …
Protective effect of alpha lipoic acid on cisplatin induced hepatotoxicity in rats.
PMID: Biotech Histochem. 2019 Nov 5:1-6. Epub 2019 Nov 5. PMID: 31687838 Abstract Title: Protective effect of alpha lipoic acid on cisplatin induced hepatotoxicity in rats. Abstract: We investigated the protective effect of alpha lipoic acid (ALA) against cisplatin (CIS) induced hepatotoxicity in rats. ALA is an antioxidant and anti-inflammatory agent that exhibits free radical …
This study provides mechanistic insights into the possible applicability of alpha-lipoic acid in the treatment of hepatic fibrosis.
PMID: Hum Exp Toxicol. 2019 Dec 4:960327119891212. Epub 2019 Dec 4. PMID: 31797693 Abstract Title: α-Lipoic acid modulates liver fibrosis: A cross talk between TGF-β1, autophagy, and apoptosis. Abstract: Autophagy and apoptosis are important players in the progression of hepatic fibrosis via activation of hepatic stellate cells (HSCs). Despite the recently depicted antifibrotic effects of …
Alpha-lipoic acid may serve as a therapeutic agent for the treatment of hyperuricemia-induced endothelial dysfunction.
PMID: Curr Med Sci. 2019 Dec ;39(6):920-928. Epub 2019 Dec 16. PMID: 31845223 Abstract Title: Protective Effects ofα-Lipoic Acid on Vascular Oxidative Stress in Rats with Hyperuricemia. Abstract: The aim of the present study was to observe the protective effects ofα-lipoic acid (ALA) on vascular injury in rats with hyperuricemia (HUA). The ALA treatment groups …
α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway.
PMID: PLoS One. 2019 ;14(12):e0226769. Epub 2019 Dec 26. PMID: 31877176 Abstract Title: α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway. Abstract: The production of reactive oxygen species (ROS) by cisplatin is one of the major mechanisms of cisplatin-induced cytotoxicity. We examined the preventive effect ofα-lipoic acid (LA) on cisplatin-induced …
Effects of passion fruit peel flour in cafeteria diet-induced metabolic disorders.
PMID: J Ethnopharmacol. 2019 Dec 19 ;250:112482. Epub 2019 Dec 19. PMID: 31866512 Abstract Title: Effects of passion fruit peel flour (Passiflora edulis f. flavicarpa O. Deg.) in cafeteria diet-induced metabolic disorders. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Passiflora edulis f. flavicarpa O. Deg. is a native Brazilian fruit known as sour or yellow passion fruit. From its …
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