Category Archives: Uncategorized

PMID:  Free Radic Res. 2019 Jul ;53(7):714-726. Epub 2019 Jul 3. PMID: 30947567 Abstract Title:  Silibinin induced apoptosis of human epidermal cancer A431 cells by promoting mitochondrial NOS. Abstract:  The antitumor effects of silibinin are of increasing interest, though its mechanism is not yet clear. The goal of this study was to clarify the mechanism …

Continue reading “Silibinin induced apoptosis of human epidermal cancer A431 cells by promoting mitochondrial NOS.”

PMID:  Molecules. 2019 Apr 19 ;24(8). Epub 2019 Apr 19. PMID: 31010153 Abstract Title:  Silibinin Downregulates the NF-κB Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia. Abstract:  Preeclampsia (PE) is a human pregnancy-specific syndrome with abnormal activation of cells from the innate immune system. The present study evaluated whether silibinin (SB) treatment …

Continue reading “Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia.”

PMID:  Int J Mol Sci. 2019 May 3 ;20(9). Epub 2019 May 3. PMID: 31058823 Abstract Title:  Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. Abstract:  Silybin is a flavonolignan extracted from(milk thistle) with hepatoprotective, antioxidant, and anti-inflammatory activity. Several studies have shown that silybin …

Continue reading “Silybin-Induced apoptosis occurs in parallel to the increase of ceramides synthesis and miRNAs secretion in HepG2 cells.”

PMID:  J Cell Physiol. 2019 Dec ;234(12):22285-22298. Epub 2019 May 9. PMID: 31073992 Abstract Title:  Silibinin encapsulation in polymersome: A promising anticancer nanoparticle for inducing apoptosis and decreasing the expression level of miR-125b/miR-182 in human breast cancer cells. Abstract:  Silibinin, a polyphenolic flavonolignan, is well-known as a safe therapeutic drug without any side effects in …

Continue reading “Silibinin encapsulation in polymersome is a promising anticancer nanoparticle against human breast cancer cells.”

PMID:  Arch Biochem Biophys. 2019 Aug 15 ;671:42-51. Epub 2019 May 11. PMID: 31085166 Abstract Title:  Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment. Abstract:  Mitochondria are dynamically regulated by fission and fusion processes. Silibinin induces apoptosis of MCF-7 and MDA-MB-231 human breast cancer cells. However, whether or not mitochondria dysfunction is involved in …

Continue reading “Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment.”

PMID:  J Physiol Sci. 2019 Jul ;69(4):643-652. Epub 2019 May 13. PMID: 31087219 Abstract Title:  Natural silibinin modulates amyloid precursor protein processing and amyloid-β protein clearance in APP/PS1 mice. Abstract:  Silibinin has been shown to attenuate cognitive dysfunction and inhibit amyloid-beta (Aβ) aggregation in Alzheimer's disease (AD) models. However, the underlying mechanism by which silibinin …

Continue reading “Silibinin is a potentially promising agent for preventing Alzheimer’s disease-associated amyloid-beta.”

PMID:  Neurochem Res. 2019 Aug ;44(8):1818-1829. Epub 2019 May 17. PMID: 31102026 Abstract Title:  Silibinin Alleviates the Learning and Memory Defects in Overtrained Rats Accompanying Reduced Neuronal Apoptosis and Senescence. Abstract:  Excessive physical exercise (overtraining; OT) increases oxidative stress and induces damage in multiple organs including the brain, especially the hippocampus that plays an important …

Continue reading “Silibinin prevented impairment of learning and memory caused by excessive physical exercise.”

PMID:  Appl Microbiol Biotechnol. 2019 Sep ;103(17):7141-7149. Epub 2019 Jun 24. PMID: 31236617 Abstract Title:  Regulation of gut microbiota in Alzheimer's disease mice by silibinin and silymarin and their pharmacological implications. Abstract:  The newly reported associations between Alzheimer's disease (AD) and gut microbiota indicate the potential of gut microbiota regulation-based therapeutic intervention for AD. Silymarin …

Continue reading “Regulation of gut microbiota in Alzheimer’s disease mice by silibinin and silymarin and their pharmacological implications.”

PMID:  Nutr Cancer. 2019 Jul 9:1-10. Epub 2019 Jul 9. PMID: 31287731 Abstract Title:  Silibinin Differentially Decreases the Aggressive Cancer Phenotype in an In Vitro Model of Obesity and Prostate Cancer. Abstract:  : Obesity increases the risk for aggressive and fatal prostate cancer (PCa). The bioactive compound silibinin has been researched for its chemopreventative properties …

Continue reading “Silibinin differentially decreases the aggressive cancer phenotype in an in vitro model of obesity and Prostate cancer.”

PMID:  Pathol Res Pract. 2019 Sep ;215(9):152530. Epub 2019 Jul 11. PMID: 31351801 Abstract Title:  Silibinin inhibited autophagy and mitochondrial apoptosis in pancreatic carcinoma by activating JNK/SAPK signaling. Abstract:  BACKGROUND: Previous investigation have indicated Silibinin induces apoptosis and JNK/SAPK in human pancreatic cancer cells. This study aims to evaluate the further mechanism of Silibinin in …

Continue reading “Silibinin inhibited autophagy and mitochondrial apoptosis in pancreatic carcinoma by activating JNK/SAPK signaling.”