PMID: Acta Pharm Sin B. 2019 Jul ;9(4):745-757. Epub 2019 Feb 22. PMID: 31384535 Abstract Title: Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway. Abstract: Non-alcoholic steatohepatitis (NASH) is a chronic metabolic syndrome and the CFLAR-JNK pathway can reverse the process of NASH. Although silibinin is …
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Silibinin could restore the sensitivity of cisplatin and taxol in drug-resistant human ovarian cancer cells and reduce durg-induced hepatotoxicity.
PMID: Cancer Manag Res. 2019 ;11:7111-7122. Epub 2019 Jul 26. PMID: 31440098 Abstract Title: Silibinin restores the sensitivity of cisplatin and taxol in A2780-resistant cell and reduces drug-induced hepatotoxicity. Abstract: Purpose: Ovarian cancer is the most lethal cancer among all gynaecological malignancies. The combination theraputics of cisplatin and taxol is widely used in clinicals for …
Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells.
PMID: Mol Cell Biochem. 2019 Oct 14. Epub 2019 Oct 14. PMID: 31612353 Abstract Title: Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion. Abstract: Human triple negative breast cancer cells, MDA-MB-231, show typical epithelial to mesenchymal transition associated with cancer progression. Mitochondria play a major role in cancer …
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Silibinin declines blue light-induced apoptosis and inflammation.
PMID: Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):4059-4065. PMID: 31631701 Abstract Title: Silibinin declines blue light-induced apoptosis and inflammation through MEK/ERK/CREB of retinal ganglion cells. Abstract: : This study aimed to assess the protective effects of silibinin on blue light-emitting diode (LED)-induced retinal ganglion cells (RGCs) damage.: Silibinin was applied in RGCs damagemodel to test …
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Silibinin ameliorates STZ-induced impairment of memory and learning.
PMID: Physiol Behav. 2020 Jan 1 ;213:112689. Epub 2019 Oct 25. PMID: 31669775 Abstract Title: Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. Abstract: Alzheimer's disease (AD) is a neurodegenerative disease, mainly characterized by cognitive dysfunction and memory impairment. Due to its pathological similarities to type …
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Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy.
PMID: Drug Des Devel Ther. 2019 ;13:3117-3126. Epub 2019 Aug 29. PMID: 31695328 Abstract Title: Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy. Abstract: Aim: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Silibinin is a flavonoid compound which has medicinal value. Previous studies revealed that silibinin exhibited an anti-fibrotic effect. …
The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic review
PMID: Iran J Basic Med Sci. 2019 Sep ;22(9):968-976. PMID: 31807239 Abstract Title: The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic review. Abstract: Ischemia-reperfusion injuries (IRI) occur in different clinical conditions such as stroke, trauma, organ transplantation, and so on. Ischemia damages mainly arise from oxygen depletion in tissues. The lack of oxygen …
The anticancer properties of silibinin: its molecular mechanism and therapeutic effect in breast cancer.
PMID: Anticancer Agents Med Chem. 2019 Dec 20. Epub 2019 Dec 20. PMID: 31858905 Abstract Title: The Anticancer Properties of Silibinin: its Molecular Mechanism and Therapeutic Effect in Breast Cancer. Abstract: BACKGROUND: Silibinin (SB), the main component of silymarin (SM) is a natural substance obtained from the seeds of the milk thistle. SM contains up …
Silybin and tangeretin has a potential-capacity to treat NASH.
PMID: Pharmacol Res. 2019 Nov 6 ;151:104519. Epub 2019 Nov 6. PMID: 31706011 Abstract Title: Combinational applicaton of silybin and tangeretin attenuates the progression of non-alcoholic steatohepatitis (NASH) in mice via modulating lipid metabolism. Abstract: Silybin (SB) is widely used to treat chronic liver diseases, especially this compound is much efficient for the treatments of …
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Aged citrus peel (Chenpi) prevents acetaminophen-induced Hepatotoxicity by epigenetically regulating Nrf2 pathway.
PMID: Am J Chin Med. 2019 ;47(8):1833-1851. Epub 2019 Dec 3. PMID: 31795743 Abstract Title: Aged Citrus Peel (Chenpi) Prevents Acetaminophen-Induced Hepatotoxicity by Epigenetically Regulating Nrf2 Pathway. Abstract: Excessive consumption of analgesic drug acetaminophen (APAP) can cause severe oxidative stress-mediated liver injury. Here, we investigated the protective effect and mechanism of aged citrus peel (Chenpi, …
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