PMID: Daru. 2019 Dec ;27(2):721-733. Epub 2019 Nov 18. PMID: 31736017 Abstract Title: Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats. Abstract: BACKGROUND: The clinical application of methotrexate (MTX), an efficacious cytotoxic drug, is restricted due to its associated liver toxicity. Ellagic acid (EA), a …
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Ellagic acid ameliorates renal ischemic-reperfusion injury.
PMID: Inflammation. 2019 Nov 26. Epub 2019 Nov 26. PMID: 31768706 Abstract Title: Ellagic Acid Ameliorates Renal Ischemic-Reperfusion Injury Through NOX4/JAK/STAT Signaling Pathway. Abstract: Ellagic acid (EA), a natural polyphenolic compound, has been proved to possess multiple biological activities including alleviating ischemic-reperfusion (I/R) injury. The aim of this current study was to investigate whether EA …
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Ellagic acid inhibits extracellular acidity-induced invasiveness and expression of COX1, COX2, snail, twist 1, and c-myc in gastric carcinoma cells.
PMID: Nutrients. 2019 Dec 10 ;11(12). Epub 2019 Dec 10. PMID: 31835645 Abstract Title: Ellagic Acid Inhibits Extracellular Acidity-Induced Invasiveness and Expression of COX1, COX2, Snail, Twist 1, and c-myc in Gastric Carcinoma Cells. Abstract: Extracellular acidity has been implicated in enhanced malignancy and metastatic features in various cancer cells. Gastric cancer cell lines (AGS …
Consumption of sunflower extract has a beneficial effect on body weight, fat mass, and lipid profile.
PMID: Nutrients. 2019 May 15 ;11(5). Epub 2019 May 15. PMID: 31096648 Abstract Title: Seed Extract Affects Weight and Body Composition of Healthy Obese Adults during 12 Weeks of Consumption: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Abstract: The aim of this pilot study was to evaluate the effects of a sunflower () seed extract, standardized …
High-dose vitamin C therapy was associated with reduced mortality in patients with severe burns.
PMID: Crit Care. 2019 12 12 ;23(1):407. Epub 2019 Dec 12. PMID: 31831039 Abstract Title: Effect of high-dose vitamin C therapy on severe burn patients: a nationwide cohort study. Abstract: BACKGROUND: Vitamin C is a well-documented antioxidant that reduces oxidative stress and fluid infusion in high doses; however, the association between high-dose vitamin C and …
Fucoidan-rich substances in E. cava could be a potential material for improving cognitive function.
PMID: Mar Drugs. 2019 Oct 17 ;17(10). Epub 2019 Oct 17. PMID: 31627432 Abstract Title: Fucoidan-Rich Substances fromImprove Trimethyltin-Induced Cognitive Dysfunction via Down-Regulation of Amyloidβ Production/Tau Hyperphosphorylation. Abstract: () was investigated to compare the effect of polyphenol and fucoidan extract and mixture (polyphenol:fucoidan = 4:6) on cognitive function. The ameliorating effect ofwas evaluated using the …
Fucoidan suppresses the gastric cancer cell malignant phenotype and production of TGF-β1 via CLEC-2.
PMID: Glycobiology. 2019 Nov 19. Epub 2019 Nov 19. PMID: 31742327 Abstract Title: Fucoidan suppresses the gastric cancer cell malignant phenotype and production of TGF-β1 via CLEC-2. Abstract: The sulfated polysaccharide fucoidan displays excellent anticancer properties with low toxicity in many kinds of cancers. However, its detailed pharmacological effect and mechanism of action in gastric …
Fucoidan is effective in protecting IPEC-1 cells against oxidative damage induced by hydrogen peroxide.
PMID: Animals (Basel). 2019 Dec 10 ;9(12). Epub 2019 Dec 10. PMID: 31835456 Abstract Title: Protective Effects of Fucoidan against Hydrogen Peroxide-Induced Oxidative Damage in Porcine Intestinal Epithelial Cells. Abstract: This study was conducted to evaluate the effectiveness of fucoidan in ameliorating hydrogen peroxide (HO)-induced oxidative stress to porcine intestinal epithelial cell line (IPEC-1). The …
Administration of Vitex agnus-castus extracts as a phytoestrogenic medicine can alleviate menopausal symptoms in women.
PMID: Korean J Fam Med. 2019 Nov ;40(6):362-367. Epub 2019 May 9. PMID: 31067851 Abstract Title: Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study. Abstract: BACKGROUND: Menopausal symptoms have remarkable negative effects on women's quality of life, justifying the need to assess various therapeutic options. This research aimed …
VAC could be developed as a health functional food to improve acute lung damage and many diseases caused by oxidative damage.
PMID: J Food Biochem. 2019 Mar ;43(3):e12750. Epub 2018 Dec 13. PMID: 31353538 Abstract Title: Vitex agnus-castus safeguards the lung against lipopolysaccharide-induced toxicity in mice. Abstract: Vitex agnus-castus (VAC, Verbenaceae) is widely used in Chinese traditional medicine as an antiinflammatory agent. This study aimed to explore the efficacy of the VAC extract to protect against …
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