PMID: Balkan Med J. 2013 Sep ;30(3):327-8. Epub 2013 Sep 1. PMID: 25207131 Abstract Title: Sudden hearing loss after rabies vaccination. Abstract: BACKGROUND: Sudden hearing loss developing after immunisation is a very rare situation. Rabies is a viral disease characterised by encephalitis and death. Treatment involves active and passive immunisation. Neurologic complications including Guillain-Barre syndrome …
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Oral polio vaccine (OPV) has failed to provide full protection to many children who have developed paralytic polio even after taking 10 or more doses of OPV. In some children, OPV has caused paralysis-vaccine associated paralytic polio.
PMID: Vaccine. 2004 Oct 22 ;22(31-32):4144-8. PMID: 15532129 Abstract Title: Polio eradication in India: some observations. Abstract: In 1988, the World Health Assembly passed resolution WHA 41.28, which committed the World Health Organization (WHO) to the global eradication of poliomyelitis by the year 2000. In spite of the combined efforts by UNICEF, National Polio Surveillance …
A case report of vaccine-associated paralytic poliomyelitis following a dose of oral polio vaccine.
PMID: Ann Trop Paediatr. 2001 Sep ;21(3):223-9. PMID: 11579860 Abstract Title: Paralytic poliomyelitis associated with the Sabin 3 revertant strain of poliovirus in Bahrain. Abstract: We report a case of vaccine-associated paralytic poliomyelitis (VAPP) in Bahrain. The case occurred in an 8-week-old infant who had received a dose of oral polio vaccine (OPV) 7 days …
The addition of adjuvants to vaccines may cause unwanted immune responses, including facial nerve paralysis and narcolepsy, and a more accurate and comprehensive strategy must be used to develop next-generation vaccines for ensuring vaccine safety.
PMID: Vaccine. 2017 02 1 ;35(5):821-830. Epub 2017 Jan 4. PMID: 28063707 Abstract Title: A novel vaccinological evaluation of intranasal vaccine and adjuvant safety for preclinical tests. Abstract: Vaccines are administered to healthy humans, including infants, so the safety and efficacy must be very high. Therefore, evaluating vaccine safety in preclinical and clinical studies, according …
Four case reports of neurological abnormalities compatible with vaccine-related poliovirus infections following oral polio vaccine.
PMID: J Pediatr. 1986 Jun ;108(6):878-81. PMID: 3012055 Abstract Title: Neurologic complications in oral polio vaccine recipients. Abstract: Between April 1982 and June 1983 four children 3 to 24 months of age were referred for evaluation of neurologic abnormalities found to be compatible with vaccine-related poliovirus infection, which had not been suspected by referring physicians. …
Seven case reports of ascending polyneuritis, due to rabies vaccine treated between 1982-1986.
PMID: Mikrobiyol Bul. 1987 Apr ;21(2):145-50. PMID: 3447020 Abstract Title: [Neurologic complications due to a sample type of rabies vaccination]. Abstract: Neuroparalytic accidents due to sample type rabies vaccination are still an important problem in our country. We present seven patients with ascending polyneuritis, due to rabies vaccine, treated between 1982-1986, and discuss the importance …
A case report live attenuated oral polio vaccine-related flaccid monoplegia.
PMID: Vaccine. 2014 Sep 22 ;32(42):5379-81. Epub 2014 Aug 12. PMID: 25131733 Abstract Title: The muscle findings in a pediatric patient with live attenuated oral polio vaccine-related flaccid monoplegia. Abstract: A pediatric patient, who was given live-attenuated oral polio vaccine twice without distinct gait disturbance during infancy, begun to present limp at 3 years. His …
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A case report of an infant with vaccine-associated paralytic poliomyelitis.
PMID: Pediatr Radiol. 2010 Dec ;40 Suppl 1:S138-40. Epub 2010 May 4. PMID: 20440488 Abstract Title: MRI findings in an infant with vaccine-associated paralytic poliomyelitis. Abstract: Although acute flaccid paralysis is a manifestation observed in several neurologic and muscular disorders, vaccine-associated paralytic poliomyelitis (VAPP) is an exceedingly rare etiology. In the clinical setting of acute …
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Skeletal muscle injury induces retrograde axonal transport of poliovirus and thereby facilitates viral invasion of the central nervous system and spinal cord damage. Intramuscular injections may increase the likelihood of vaccine-associated polio.
PMID: J Virol. 1998 Jun ;72(6):5056-60. PMID: 9573275 Abstract Title: Mechanism of injury-provoked poliomyelitis. Abstract: Skeletal muscle injury is known to predispose its sufferers to neurological complications of concurrent poliovirus infections. This phenomenon, labeled"provocation poliomyelitis,"continues to cause numerous cases of childhood paralysis due to the administration of unnecessary injections to children in areas where poliovirus …
The rapid translation of the polio vaccine had serious drawbacks.
PMID: Clin Transl Sci. 2010 Aug ;3(4):182-5. PMID: 20718820 Abstract Title: Lessons from the Salk polio vaccine: methods for and risks of rapid translation. Abstract: The Salk inactivated poliovirus vaccine is one of the most rapid examples of bench-to-bedside translation in medicine. In the span of 6 years, the key basic lab discoveries facilitating the …
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