PMID: J BUON. 2019 Sep-Oct;24(5):1964-1969. PMID: 31786862 Abstract Title: Inhibition of cancer cell growth by oleanolic acid in multidrug resistant liver carcinoma is mediated via suppression of cancer cell migration and invasion, mitochondrial apoptosis, G2/M cell cycle arrest and deactivation of JNK/p38 signalling pathway. Abstract: PURPOSE: Liver cancer accounts for considerable mortality across the globe. …
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Oleanolic acid exerts a neuroprotective effect against microglial cell activation by modulating cytokine release and antioxidant defense systems.
PMID: Biomolecules. 2019 Nov 1 ;9(11). Epub 2019 Nov 1. PMID: 31683841 Abstract Title: Oleanolic Acid Exerts a Neuroprotective Effect Against Microglial Cell Activation by Modulating Cytokine Release and Antioxidant Defense Systems. Abstract: Microglia respond to adverse stimuli in order to restore brain homeostasis and, upon activation, they release a number of inflammatory mediators. Chronic …
Ginkgo biloba extract alleviates methotrexate-induced renal injury.
PMID: Biomolecules. 2019 Nov 3 ;9(11). Epub 2019 Nov 3. PMID: 31684190 Abstract Title: Extract Alleviates Methotrexate-Induced Renal Injury: New Impact on PI3K/Akt/mTOR Signaling and MALAT1 Expression. Abstract: Renal injury induced by the chemotherapeutic agent methotrexate (MTX) is a serious adverse effect that has limited its use in the treatment of various clinical conditions. The …
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Caffeine prevents neurodegeneration and behavioral alterations in a mice model of agitated depression.
PMID: Prog Neuropsychopharmacol Biol Psychiatry. 2019 Nov 9 ;98:109776. Epub 2019 Nov 9. PMID: 31707092 Abstract Title: Caffeine prevents neurodegeneration and behavioral alterations in a mice model of agitated depression. Abstract: Longitudinal and some experimental studies have showed the potential of caffeine to counteract some depressive behaviors and synaptic dysfunctions. In this study, we investigated …
Caffeine may abrogate lipopolysaccharide-induced oxidative stress and neuroinflammation.
PMID: Biomolecules. 2019 Nov 8 ;9(11). Epub 2019 Nov 8. PMID: 31717470 Abstract Title: Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains. Abstract: Herein, we assayed the antioxidant and anti-inflammatory potential of caffeine in a lipopolysaccharide (LPS)-injected mouse model of neurodegeneration and synaptic impairment. For this purpose, LPS …
Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation.
PMID: Clin Cancer Res. 2003 Jul ;9(7):2866-75. PMID: 12855667 Abstract Title: Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation. Abstract: Betulinic acid, a naturally occurring triterpene found in the bark of the white birch tree, has been demonstrated to induce programmed cell death with melanoma and certain neuroectodermal tumor …
Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.
PMID: Cancer Res. 2007 Mar 15 ;67(6):2816-23. PMID: 17363604 Abstract Title: Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Abstract: Betulinic acid is a pentacyclic triterpene natural product initially identified as a melanoma-specific cytotoxic agent that exhibits low toxicity in animal models. Subsequent studies show that betulinic acid induces apoptosis …
Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system.
PMID: J Vet Sci. 2014 ;15(1):141-8. Epub 2013 Dec 27. PMID: 24378582 Abstract Title: Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice. Abstract: Betulinic acid (BA), a pentacyclic lupane-type triterpene, has a wide range of bioactivities. The main objective of this work was to evaluate the hepatoprotective activity of BA …
The inhibitory effects of B. monniera and its constituents on pancreatic lipase activity and plasma triglyceride level are reported for the first time.
PMID: Nat Prod Commun. 2016 Dec ;11(12):1855-1858. PMID: 30508350 Abstract Title: Caffeic Acid Derivatives from Bacopa monniera Plants as Inhibitors of Pancreatic Lipase Activity and their Structural Requirements. Abstract: The methanol extract of whole Bacopa monniera plants inhibited pancreatic lipase activity in vitro. From this extract we have reported the isolation of 11 triterpene glycosides …
This is the first study to test the efficacy of Cognition Support Formula® on cognition in older adults with subjective cognitive impairment.
PMID: Trials. 2019 Jun 10 ;20(1):345. Epub 2019 Jun 10. PMID: 31182153 Abstract Title: Efficacy of Cognition Support Formula® on cognitive function in older adults with subjective cognitive impairment: a protocol for a 26-week, randomised, double-blind, placebo-controlled trial. Abstract: BACKGROUND: Due to an ageing population in Australia there has been an increase in the number …
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