PMID: Strahlenther Onkol. 2010 Mar ;186(3):143-8. Epub 2010 Feb 22. PMID: 20339825 Abstract Title: Betulinic acid a radiosensitizer in head and neck squamous cell carcinoma cell lines. Abstract: BACKGROUND AND PURPOSE: Betulinic acid, a pentacyclic triterpene, is a new cytotoxic compound active on melanoma, neuroblastoma, glioblastoma and head and neck squamous cell carcinoma (HNSCC) cells. …
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Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.
PMID: Int J Cancer. 2010 Jul 15 ;127(2):282-92. PMID: 19937797 Abstract Title: Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. Abstract: STAT3 activation has been associated with survival, proliferation and invasion of various human cancers. Whether betulinic acid, a pentacyclic triterpene, can modulate the STAT3 …
Betulinic acid: a natural product with anticancer activity.
PMID: Mol Nutr Food Res. 2009 Jan ;53(1):140-6. PMID: 19065582 Abstract Title: Betulinic acid: a natural product with anticancer activity. Abstract: Betulinic acid (BA) is a naturally occurring pentacyclic triterpene that exhibits a variety of biological activities including potent antitumor properties. This anticancer activity has been linked to its ability to directly trigger mitochondrial membrane …
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Betulinic acid protects against cerebral ischemia/reperfusion injury by activating the PI3K/Akt signaling pathway.
PMID: Biomed Pharmacother. 2016 Dec ;84:1533-1537. Epub 2016 Nov 18. PMID: 27876208 Abstract Title: Betulinic acid protects against cerebral ischemia/reperfusion injury by activating the PI3K/Akt signaling pathway. Abstract: Betulinic acid (BA), a naturally occurring pentacyclic lupane group triterpenoid, has been demonstrated to protect against ischemia/reperfusion-induced renal damage. However, the effects of BA on cerebral ischemia/reperfusion …
Betulinic acid Inhibits cell proliferation in human oral squamous cell carcinoma.
PMID: Oncol Res. 2017 Aug 7 ;25(7):1141-1152. Epub 2017 Jan 20. PMID: 28109089 Abstract Title: Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling. Abstract: Oral squamous cell carcinoma (OSCC) is a common cancer of the head and neck. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid. …
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Betulinic acid-mediated apoptosis in human prostate cancer cells involves p53 and NF-κB pathways.
PMID: Molecules. 2017 Feb 10 ;22(2). Epub 2017 Feb 10. PMID: 28208611 Abstract Title: Betulinic Acid-Mediated Apoptosis in Human Prostate Cancer Cells Involves p53 and Nuclear Factor-Kappa B (NF-κB) Pathways. Abstract: Defects in p53 and nuclear factor-kappa B (NF-κB) signaling pathways are frequently observed in the initiation and development of various human malignancies, including prostate …
Betulinic acid promotes TRAIL function on liver cancer progression inhibition through p53/Caspase-3 signaling activation.
PMID: Biomed Pharmacother. 2017 Apr ;88:349-358. Epub 2017 Jan 21. PMID: 28119237 Abstract Title: Betulinic acid promotes TRAIL function on liver cancer progression inhibition through p53/Caspase-3 signaling activation. Abstract: Betulinic acid (BA), isolated from the tree bark, is a pentacyclic triterpenoid, showing inhibitory role in cancer cells. However, the effects of BA treatment on liver …
Removal of donor human leukocyte antigen class I proteins with papain: translation for possible whole organ practices.
PMID: Transplantation. 2015 Apr ;99(4):724-30. PMID: 25340603 Abstract Title: Removal of donor human leukocyte antigen class I proteins with papain: translation for possible whole organ practices. Abstract: BACKGROUND: Papain is a protease with potential use in transplantation because of its targeted capacity to selectively remove human leukocyte antigen (HLA) class I proteins from donor human …
Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications.
PMID: Life Sci. 2018 Sep 15 ;209:24-33. Epub 2018 Aug 1. PMID: 30076920 Abstract Title: Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications. Abstract: A natural product betulinic acid (BA) has gained a huge significance in the recent years for its strong cytotoxicity. Surprisingly, in spite of being an interesting cancer …
Calcium regulates mitochondrial matrix pH.
PMID: J Biol Chem. 2004 Mar 19 ;279(12):11521-9. Epub 2003 Dec 30. PMID: 14701849 Abstract Title: Mitochondrial pH monitored by a new engineered green fluorescent protein mutant. Abstract: We here describe a new molecularly engineered green fluorescent protein chimera that shows a high sensitivity to pH in the alkaline range. This probe was named mtAlpHi, …
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