PMID: J Cell Physiol. 2018 12 ;233(12):9538-9547. Epub 2018 Jun 26. PMID: 29943808 Abstract Title: Zerumbone inhibits epithelial-mesenchymal transition and cancer stem cells properties by inhibiting theβ-catenin pathway through miR-200c. Abstract: Colorectal cancer (CRC) is one of the most lethal and rampant human malignancies in the world. Zerumbone, a sesquiterpene isolated from subtropical ginger, has …
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Zerumbone could be a potential protective agent for acute lung injury.
PMID: Chin J Physiol. 2018 Jun ;61(3):171-180. PMID: 29962177 Abstract Title: Zerumbone from Zingiber zerumbet Ameliorates Lipopolysaccharide-Induced ICAM-1 and Cytokines Expression via p38 MAPK/JNK-IκB/NF-κB Pathway in Mouse Model of Acute Lung Injury. Abstract: Acute lung injury (ALI) is a clinical syndrome with high morbidity and mortality rates mainly caused by Gram-negative bacteria. Nevertheless, an effective …
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Zerumbone can inhibit the proliferation and induce apoptosis of esophageal cancer EC-109 cells.
PMID: Oncol Lett. 2018 Oct ;16(4):4379-4383. Epub 2018 Jul 20. PMID: 30197671 Abstract Title: Effects of zerumbone on proliferation and apoptosis of esophageal cancer cells and on P53 and Bcl-2 expression levels. Abstract: The effects of zerumbone on the proliferation and apoptosis of esophagus cancer cells and on the P53 and Bcl-2 expression levels were …
Zerumbone-loaded nanostructured lipid carrier induces apoptosis of canine mammary adenocarcinoma cells.
PMID: Biomed Res Int. 2018 ;2018:8691569. Epub 2018 Oct 15. PMID: 30410940 Abstract Title: Zerumbone-Loaded Nanostructured Lipid Carrier Induces Apoptosis of Canine Mammary Adenocarcinoma Cells. Abstract: Canine mammary gland tumor (CMT) is the most common tumor in intact female dog. Zerumbone (ZER) has promising anticancer properties, but plagued with poor water solubility, poor absorption, bioavailability, …
Zerumbone inhibits migration in ESCC via promoting Rac1 ubiquitination.
PMID: Biomed Pharmacother. 2019 Jan ;109:2447-2455. Epub 2018 Dec 1. PMID: 30551505 Abstract Title: Zerumbone inhibits migration in ESCC via promoting Rac1 ubiquitination. Abstract: Zerumbone has been reported to maintain the anti-cancer effects in many malignant cells. However, the effect and mechanism of Zerumbone on esophageal squamous cell carcinomas (ESCC) is rarely investigated. Here we …
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Zerumbone suppresses human colorectal cancer invasion and metastasis.
PMID: Nutr Cancer. 2019 ;71(1):159-171. Epub 2019 Jan 16. PMID: 30650987 Abstract Title: Zerumbone Suppresses Human Colorectal Cancer Invasion and Metastasis via Modulation of FAk/PI3k/NFκB-uPA Pathway. Abstract: The current study explored the basic molecular mechanisms of zerumbone (ZER), an herbal compound, in inhibiting the migration and invasion of colorectal cancer (CRC) cells in vitro. Two …
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The anti-inflammatory activity of zerumbone was so much significant that even strong oxidant zymogen was not able to produce reactive oxygen species.
PMID: Pak J Biol Sci. 2018 Jan ;21(9):475-479. PMID: 30724050 Abstract Title: Immunomodulation of Zerumbone via Decreasing the Production of Reactive Oxygen Species from Immune Cells. Abstract: BACKGROUND AND OBJECTIVE: Zerumbone has been reported to exert anti-inflammatory, anti-ulcer and anti-hyperglycemic effects but the specific mechanism through which zerumbone exerts its anti-inflammatory action through inhibiting reactive …
The current review briefly summarizes the modes of action and therapeutic potential of zerumbone against various cancers.
PMID: Molecules. 2019 Feb 18 ;24(4). Epub 2019 Feb 18. PMID: 30781671 Abstract Title: Potential of Zerumbone as an Anti-Cancer Agent. Abstract: Cancer is still a major risk factor to public health globally, causing approximately 9.8 million deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer treatment, there are still few effective …
Dietary zerumbone from shampoo ginger: new insights into its antioxidant and anticancer activity.
PMID: Food Funct. 2019 Mar 20 ;10(3):1629-1642. PMID: 30834410 Abstract Title: Dietary zerumbone from shampoo ginger: new insights into its antioxidant and anticancer activity. Abstract: The dietary sesquiterpene dienone zerumbone (ZER) selectively targets cancer cells, inducing mitochondrial dysfunction and apoptosis, and protects non-cancerous cells towards oxidative stress and insult. This study examines the in vitro …
Dietary zerumbone ameliorates hepatotoxin-mediated acute and chronic liver injury.
PMID: Phytother Res. 2019 May ;33(5):1538-1550. Epub 2019 Mar 14. PMID: 30868670 Abstract Title: Dietary zerumbone, a sesquiterpene, ameliorates hepatotoxin-mediated acute and chronic liver injury in mice. Abstract: Acute liver injury (ALI) is a life-threatening clinical syndrome. Long-lasting liver injury can lead to chronic hepatic inflammation and fibrogenic responses. Zerumbone (ZER), the main constituent of …
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