Category Archives: Uncategorized

PMID:  Molecules. 2019 May 22 ;24(10). Epub 2019 May 22. PMID: 31121820 Abstract Title:  Zerumbone Protects against Carbon Tetrachloride (CCl)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving the TLR4/NF-κB/COX-2 Pathway. Abstract:  The natural compound Zerumbone (hereinafter referred to as ZER), a monocyclic sesquiterpenoid, has been reported to possess …

Continue reading “Zerumbone protects against carbon tetrachloride-induced acute liver injury.”

PMID:  Can J Microbiol. 2019 Oct ;65(10):713-721. Epub 2019 Jun 3. PMID: 31158320 Abstract Title:  Zerumbone inhibitsbiofilm formation and hyphal growth. Abstract:  biofilm formation is considered an important matter because it can lead to strong resistance to conventional antifungal agents. Hyphae formed bycan also act as an important virulence factor related to its biofilm. The …

Continue reading “Zerumbone inhibits Candida albicans biofilm formation and hyphal growth.”

PMID:  Molecules. 2019 Jul 13 ;24(14). Epub 2019 Jul 13. PMID: 31337024 Abstract Title:  Zerumbone Induces Apoptosis in Breast Cancer Cells by Targetingαvβ3 Integrin upon Co-Administration with TP5-iRGD Peptide. Abstract:  Cell-penetrating peptides (CPPs) are highly promising tools to deliver therapeutic molecules into tumours.αVβ3 integrins are cell-matrix adhesion receptors, and are considered as an attractive target …

Continue reading “Zerumbone induces apoptosis in breast cancer cells.”

PMID:  Microb Pathog. 2019 Dec ;137:103768. Epub 2019 Oct 1. PMID: 31585154 Abstract Title:  Efficacy of zerumbone against dual-species biofilms of Candida albicans and Staphylococcus aureus. Abstract:  Candida albicans and Staphylococcus aureus are the most common opportunistic pathogens that co-exist as mixed biofilms. Dual-species biofilms of C. albicans and S. aureus cause nosocomial medical device-related …

Continue reading “Efficacy of zerumbone against dual-species biofilms of Candida albicans and Staphylococcus aureus.”

PMID:  Folia Neuropathol. 2019 ;57(3):277-284. PMID: 31588714 Abstract Title:  Zerumbone promotes proliferation of endogenous neural stem cells in vascular dementia by regulating Notch signalling. Abstract:  INTRODUCTION: Present investigation determines the effect of zerumbone on the proliferation of stem cells in vascular dementia (VD) rats.MATERIAL AND METHODS: Vascular dementia was induced by cerebral ischemia and reperfusion …

Continue reading “Zerumbone protects the neuronal injury and ameliorates the cognitive function by stimulating the proliferation of endogenous neural stem cells.”

PMID:  Alzheimers Dement (N Y). 2019 ;5:637-643. Epub 2019 Oct 22. PMID: 31687471 Abstract Title:  Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats. Abstract:  Introduction: We investigated the effects of zerumbone (1 and 10 mg/kg) against hyperactivity, anxiety and memory impairment in scopolamine-induced dementia in Sprague-Dawley rats.Methods: Open field tests, elevated plus …

Continue reading “Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats.”

PMID:  Pharmacol Res. 2019 Nov 2 ;150:104489. Epub 2019 Nov 2. PMID: 31689519 Abstract Title:  Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota. Abstract:  Phloretin, extracted from the pericarp and velamen of apples or pears, is a dihydrochalcone flavonoid with anti-bacterial and anti-inflammatory activities. It has been reported that …

Continue reading “Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota.”

PMID:  J Cancer. 2019 ;10(26):6543-6556. Epub 2019 Oct 21. PMID: 31777584 Abstract Title:  Synergistic inhibition of lung cancer cells by EGCG and NF-κB inhibitor BAY11-7082. Abstract:  Lung cancer has a poor 5-year survival rate and is the leading cause of cancer-related deaths worldwide. Thus, the development of more efficient therapeutic strategies is urgently needed. Many …

Continue reading “Synergistic inhibition of lung cancer cells by EGCG and NF-κB inhibitor BAY11-7082.”

PMID:  J Pharmacol Exp Ther. 2019 Dec ;371(3):663-674. Epub 2019 Oct 3. PMID: 31582423 Abstract Title:  Epicatechin-3-Gallate Signaling and Protection against Cardiac Ischemia/Reperfusion Injury. Abstract:  At concentrations found in humans after ingestion of one to two cups of green tea, epicatechin-3-gallate (ECG) modulates Na/K-ATPase conformation and activity. Akin to ouabain, an archetypal Na/K-ATPase ligand of …

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PMID:  Cancers (Basel). 2019 Oct 5 ;11(10). Epub 2019 Oct 5. PMID: 31590367 Abstract Title:  Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts. Abstract:  Pancreatic cancer is a complex disease, in need of new therapeutic approaches. In this study, we explored the effect and mechanism of action of …

Continue reading “EGCG is a strong combination partner of gemcitabine reducing pancreatic cancer cell growth by suppressing glycolysis.”