PMID: J Med Food. 2015 Dec ;18(12):1327-32. Epub 2015 Sep 1. PMID: 26325006 Abstract Title: Flavonol Intake and Cognitive Decline in Middle-Aged Adults. Abstract: Cognitive decline occurs with age and may be slowed by dietary measures, including increased intake of dietary phytochemicals. However, evidence from large and long-term studies of flavonol intake is limited. Dietary …
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PMID: Dig Dis Sci. 2012 Feb ;57(2):355-63. Epub 2011 Sep 8. PMID: 21901258 Abstract Title: Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis in mice. Abstract: BACKGROUND: In ulcerative colitis (UC), reduction of inflammation may represent a key mechanism in UC therapy, and anti-inflammatory agents would be good candidates for preventing UC. Kaempferol, a …
PMID: Toxicology. 2012 Feb 6 ;292(1):53-62. Epub 2011 Dec 6. PMID: 22155320 Abstract Title: Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. Abstract: The long-term clinical usefulness of doxorubicin (DOX), an anthracycline with potent antitumor activity, is limited by DOX-induced cardiotoxicity. Kaempferol, one of the most common dietary flavonoids, is known to have …
PMID: J Diabetes Res. 2015 ;2015:532984. Epub 2015 May 7. PMID: 26064984 Abstract Title: Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreaticβ -Cell Mass in Middle-Aged Obese Diabetic Mice. Abstract: Insulin resistance and a progressive decline in functionalβ-cell mass are hallmarks of developing type 2 diabetes (T2D). Thus, searching for natural, low-cost compounds to …
PMID: Redox Rep. 2015 Sep ;20(5):198-209. Epub 2014 Dec 12. PMID: 25494817 Abstract Title: Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats. Abstract: OBJECTIVE: The aim of the present study was to evaluate the protective effect of kaempferol against oxidative stress in streptozotocin (STZ)-induced diabetic rats.METHODS: Diabetes was induced in …
PMID: Oncol Rep. 2014 Mar ;31(3):1350-6. Epub 2014 Jan 7. PMID: 24399193 Abstract Title: Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling. Abstract: Kaempferol has been shown to inhibit cell growth, induce apoptosis and cell cycle arrest in several tumors, but not in renal cell carcinoma (RCC). In the …
PMID: Int Immunopharmacol. 2015 Sep ;28(1):744-50. Epub 2015 Aug 9. PMID: 26263168 Abstract Title: Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats. Abstract: Recent studies show that inflammation underlies the metabolic disorders of insulin resistance and type 2 diabetes mellitus. Since kaempferol, a naturally occurring flavonoid, has been described to …
PMID: Pharm Biol. 2016 ;54(6):984-92. Epub 2015 Oct 12. PMID: 26459663 Abstract Title: The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans. Abstract: CONTEXT: Fungal infections caused by fluconazole-resistant Candida albicans are an intractable clinical problem, calling for new efficient antifungal drugs. Kaempferol, an active flavonoid, has been considered a …
PMID: Am J Chin Med. 2015 ;43(2):241-54. Epub 2015 Mar 19. PMID: 25787296 Abstract Title: Hepatoprotective effect of kaempferol against alcoholic liver injury in mice. Abstract: Kaempferol is a biologically active component present in various plants. The hepatoprotective effect of kaempferol in drug-induced liver injury has been proven, while its effect against alcoholic liver injury …
PMID: Endocrine. 2018 04 ;60(1):83-94. Epub 2018 Feb 1. PMID: 29392616 Abstract Title: Kaempferol attenuates hyperglycemia-induced cardiac injuries by inhibiting inflammatory responses and oxidative stress. Abstract: PURPOSE: Suppression of inflammation and oxidative stress is an attractive strategy to against diabetic cardiomyopathy (DCM). Kaempferol (KPF) exerts both anti-inflammatory and antioxidant pharmacological properties. However, little is known …
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